Diagnostic immunologique de la maladie cœliaque chez l’enfant. Mise au point

Admou, Brahim; Sbihi, M.; Bienvenu, F.; Chabaâ, L.

doi:10.1016/j.immbio.2009.06.005

Cited by 4 publications

(7 citation statements)

References 30 publications

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“…For over 25 years [ 12 , 18 ], CD presentation has evolved [ 19 ] due to the advent of new serological markers that allow for the detection of CD with high sensitivity and specificity [ 12 , 18 ]. However, the identification of anti-transglutaminase (tTG) antibodies, which are the most widely used serologic markers and which revealed frustrating clinical manifestations [ 4 ], has enabled significant advances in CD diagnosis [ 20 , 21 ]. Despite these advances, the disease remains severely underdiagnosed [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Even in developed countries, on average, five cases go undiagnosed for each one diagnosed [ 13 ], while in developing countries, diagnosis is still based on symptomatic forms [ 22 ]. Undiagnosed CD in childhood has serious consequences in adulthood [ 20 , 23 ], leading to short stature and low female fertility [ 24 ]. This should encourage the optimization of diagnostic conditions in children by generalizing autoantibody testing, which is currently the first step of the disease's diagnosis [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Celiac Disease in Moroccan Children: Diagnostic Characteristics and Determinants of Diagnosis Delay

Mouslih,

El Rhazi,

Bahra

et al. 2023

Cureus

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Advances in the field of celiac disease have led to a better understanding of the disease, but it remains underdiagnosed and poses a daily challenge to clinicians to make a timely diagnosis. This study aims to analyze and describe diagnosis characteristics, diagnosis delay, and the factors influencing this delay in Moroccan children. Our study included 324 children diagnosed during the study period from January 01, 2010, to December 30, 2019, at the Department of Pediatrics, Hassan II University Hospital in Fez, Morocco. Data were collected using a collection grid and then analyzed using SPSS 26 software (IBM Corp., Armonk, NY). The results showed a female predominance (n=197, 60.8%), with a diagnosis age of 73.8±46.8 months. The mean age onset of symptoms was 51.3±41.2 months, and the diagnosis delay was 22.2±22.6 months, with only 32.7% (n=106) diagnosed less than 12 months after symptom onset. The most common consultation reason was diarrhea (n=149, 46%) and growth delay (n=105, 32.4%) and 50.5% (n=98) of parents consulted a pediatrician first. The three clinical, serologic, and histologic criteria made it possible to agree on the diagnosis, with the clinical profile dominated by the digestive form at 84.9% (n=279), serologic with the presence of IgA transglutaminase antibodies (95.7%; n=310), and histologic with villous atrophy at 91.7% (n=297). Unfortunately, 14.8% (n=48) of the children were diagnosed with a celiac crisis. The multivariate logistic regression analysis showed that as symptoms onset age increased, so did the risk of late diagnosis (OR=0.96, 95% CI: 0.94 to 0.97, p<0.001). Age of diagnosis was also associated with delayed diagnosis (OR=19.68, 95% CI: 8.77 to 44.15, p<0.001). The combination of these variables and the diagnosis delay argues in favor of adopting a diagnosis strategy that includes raising awareness among healthcare professionals of the need to identify typical and atypical cases early in order to reduce the adverse effects of late diagnosis and the complications that can result. This methodology for improving diagnoses may also unearth previously unknown aspects of celiac disease in Moroccan children.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Celiac Disease in Moroccan Children: Diagnostic Characteristics and Determinants of Diagnosis Delay

Mouslih,

El Rhazi,

Bahra

et al. 2023

Cureus

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“…The ingestion of gluten found in wheat (gliadin), barley (ordein), and rye (secalin) causes immune reactions in some susceptible people [1]. This is celiac disease (CD), which destroys intestinal villi by causing poor absorption of nutrients [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of adherence to gluten-free diets in Moroccan celiac patients and factors of adherence failure

Guennouni

Bourrhouate²,

Khoudri

et al. 2021

E3S Web Conf.

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The prevalence of celiac disease (CD) is increasing in the world. In Morocco, its incidence is also increasing considerably. The gluten-free diet (GFD) remains the only effective treatment so far. Its effectiveness depends essentially on good adherence to this diet. However, several factors hinder adherence by contributing to diet failure. Within this framework, this study aims to evaluate adherence to this diet in celiac children and adolescents continuing in a tertiary health center. The article also looks to identify the different factors influencing adherence to GFD in Morocco. The results show from serological and/or biopsy tests on 238 celiac patients that half had good adherence and 13% had poor adherence. The questionnaire aimed at 127 parents or proxies of celiac children and adolescents shows that several factors are responsible for the failure to adhere to the diet such as the role of the mass media, cultural and psychological factors. The exorbitant price, nutritional quality, and low availability of gluten-free products play a major role in GFD failure. Low socio-economic factors have a negative influence on the adherence to the GFD.

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“…Celiac disease is a chronic autoimmune disease that affects the small intestines. It affects people who are genetically predisposed to gluten molecules (Admou, Sbihi, & Bienvenu, 2009). Gliadins of wheat, secalins of rye, and hordeins of barley are the part of gluten that are responsible for intolerance (Wieser & Koehler, 2008).…”

Section: Introductionmentioning

confidence: 99%

Nutritional quality of gluten‐free products in Moroccan supermarkets and e‐commerce platforms

Guennouni¹,

Khoudri²,

Bourrhouat³

et al. 2020

Cereal Chem

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Background and objectives Gluten found in wheat, barley, and rye causes celiac disease. The treatment of this disease is based on the gluten‐free diet. This diet involves the consumption of gluten‐free foods including gluten‐free products (GFPs) developed by manufacturers. The objective of this survey is to estimate the nutritional composition of the gluten‐free products by comparing them to equivalent regular products (RPs) containing gluten. Findings While the fiber contents were higher in the gluten‐free products, protein and sugar contents were lower in comparison with regular products (p < .0001). The differences in total energy, total carbohydrate, saturated fat, and salt differ from one category to another. The number of gluten‐free products that have been fortified with iron and vitamins was limited. The category of “Bread and Bakery products” which is the most consumed in Morocco is characterized by a low and high protein and fiber content, respectively (p < .001; p = .015, respectively). Conclusions The nutritional quality of the gluten‐free products is unbalanced. A significant protein deficiency is noted. Significance and novelty It is important to improve the nutritional quality of the gluten‐free products by replacing gluten with hydrocolloids and protein rich enzymes. A fortification by iron and vitamins remains a necessity to overcome the deficit.

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Diagnostic immunologique de la maladie cœliaque chez l’enfant. Mise au point

Cited by 4 publications

References 30 publications

Celiac Disease in Moroccan Children: Diagnostic Characteristics and Determinants of Diagnosis Delay

Celiac Disease in Moroccan Children: Diagnostic Characteristics and Determinants of Diagnosis Delay

Evaluation of adherence to gluten-free diets in Moroccan celiac patients and factors of adherence failure

Nutritional quality of gluten‐free products in Moroccan supermarkets and e‐commerce platforms

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