Diagnostic Importance of Café-Au-Lait Spot in Neurofibromatosis

Crowe, Frank W.

doi:10.1001/archinte.1953.00240180067008

Cited by 130 publications

(24 citation statements)

References 6 publications

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“…30], in our patients CLS were found in highest frequency reported in the literature. Moreover, the prevalence of multiple C'LS was also remarkably high: 0.8% of the 939 patients exhibited more than 3 spots (a fact reported by Crowe [16) Although 6 CLS are considered to be significant for the diagnosis of neurofibromatosis, none of our 3 patients exhibiting such a number of CLS had other overt stigmata of diseases that have been reported to be associated with increased prevalence of these spots.…”

Section: Discussionsupporting

confidence: 53%

Frequency of Congenital Nevi, Nevi spili and Café-au-Lait Spots and Their Relation to Nevus Count and Skin Complexion in 939 Children

Sigg

Pelloni²,

Schnyder³

1990

Dermatology

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To determine the prevalence of congenital melanonevocytic nevi (CMN), of so-called congenital nevus-like nevi (CNLN), nevi spili (NS) and café-au-lait spots (CLS) in childhood, a series of 939 children aged 8–16 years had total skin examination. CMN/CNLN were observed in a frequency of 5.9% NS in 2.1 % and CLS even in 32.7%. Except CLS (which occurred more frequently in boys) all of these lesions were equally represented in both sexes. According to the classification of Kopf and coworkers, 44/55 CMN/CNLN were small and 11/55 medium-sized. CMN/CNLN affected preferentially trunk and upper limbs while head and neck were spared. Such nevi occurred more frequently in dark types of skin complexion and showed a tendency to be more frequent in groups of patients with increased average number of acquired melanonevocytic nevi. Remarkably, CLS were also found in 23/55 (41.7%) children with CMN/CNLN and in 12/20 (60%) children with NS (in a higher frequency than such combinations have to be expected). Compared with the data from other studies both CMN/CNLN and CLS in our patients were observed in highest prevalence in the literature. Since the frequency of CLS in adults is much lower, it cannot be ruled out that some of the CLS disappear in adolescence.

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Section: Discussionsupporting

confidence: 53%

Frequency of Congenital Nevi, Nevi spili and Café-au-Lait Spots and Their Relation to Nevus Count and Skin Complexion in 939 Children

Sigg

Pelloni²,

Schnyder³

1990

Dermatology

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“…In this series, 15 (2.5%) were found to have such lesions. In addition, 14 (2.3%) had nevi spili and 83 (13.8%) had caf\l=e'\au lait spots.…”

mentioning

confidence: 51%

Prevalence of congenital-nevus-like nevi, nevi spili, and cafe au lait spots

Kopf¹

1985

Archives of Dermatology

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“…Crowe and Schull (1953) found that one cafe-au-lait patch of more than 1-5 cm in diameter was present in 8 to 9 % of a mental hospital population, and two cafe-au-lait patches were present in 1 %. Fifty-three patients with tuberous sclerosis were included in their control group and did not differ from the main group.…”

Section: Discussionmentioning

confidence: 96%