Diagnostic index of three-dimensional osteoarthritic changes in temporomandibular joint condylar morphology

Abstract

This study aimed to investigate imaging statistical approaches for classifying three-dimensional (3-D) osteoarthritic morphological variations among 169 temporomandibular joint (TMJ) condyles. Cone-beam computed tomography scans were acquired from 69 subjects with long-term TMJ osteoarthritis (OA), 15 subjects at initial diagnosis of OA, and 7 healthy controls. Three-dimensional surface models of the condyles were constructed and SPHARM-PDM established correspondent points on each model. Multivariate analysis of covariance and direction-projection-permutation (DiProPerm) were used for testing statistical significance of the differences between the groups determined by clinical and radiographic diagnoses. Unsupervised classification using hierarchical agglomerative clustering was then conducted. Compared with healthy controls, OA average condyle was significantly smaller in all dimensions except its anterior surface. Significant flattening of the lateral pole was noticed at initial diagnosis. We observed areas of 3.88-mm bone resorption at the superior surface and 3.10-mm bone apposition at the anterior aspect of the long-term OA average model. DiProPerm supported a significant difference between the healthy control and OA group ([Formula: see text]). Clinically meaningful unsupervised classification of TMJ condylar morphology determined a preliminary diagnostic index of 3-D osteoarthritic changes, which may be the first step towards a more targeted diagnosis of this condition.

Comparison of Morphologic Parameters of Temporomandibular Joint for Asymptomatic Subjects Using the Two-Dimensional and Three-Dimensional Measuring Methods

“…In this study, the mean values of MJS and SJS were 2.81 ± 0.35 mm and 2.27 ± 0.18 mm measured in 3D models, respectively. Other morphologic parameters of TMJ measured in this study were also similar to previous studies [18, 28–30]. Therefore, the results were accurate in this study.…”

Occurrence of signs of osteoarthritis/arthrosis in the temporomandibular joint on panoramic radiographs in Swedish women

“…In the definition of OA, especially in the knee, Kellgren's definitions are often used . As clear definitions are not available when it comes to OA in the TMJ, the discussion about the best or acceptable technique and criteria is ongoing . It is not possible to distinguish between OA and remodelling in a PAN according to Ahmad et al .…”

The role of biomechanical anatomical modeling via computed tomography for identification of restrictive allograft syndrome

“…Medical image registration techniques have been used to evaluate the results of radiotherapy 12,13 as well as in evaluating regional anatomical changes. 14,15 In addition, there are studies using parametric response mapping (PRM) with computed tomography (CT) to assess obstructive lung diseases such as COPD and BOS. 16,17 There are also a few animal and human studies that have used Jacobian analysis of displacement fields to evaluate the different ventilation phases.…”