2007
DOI: 10.1159/000098179
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Diagnostic Methods for Platelet Function Analysis

Abstract: Platelets play a key role in the regulation of haemostasis, clot stability and retraction, vascular repair, and exert an increasingly recognised function in host defence. Conversely, platelets are also implied in many pathophysiological processes, such as thrombosis, haemorrhage, inflammation, atherogenesis, tumour growth and metastasis. Thus quantitative and qualitative platelet alterations have been associated with distinct clinical diseases, including cardiovascular diseases, diabetes, tumour metastasis and… Show more

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Cited by 8 publications
(4 citation statements)
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“…Since these three analyzers monitor different aspects of platelet function and have different limitations, the selection of the right test system depends on the right question [35] ( Görlinger/Jambor/Hanke/Dirkmann/Adamzik/ Hartmann/Rahe-Meyer • • dynamic (with high shear stress blood flow), • static (without high shear stress blood flow).…”
Section: Ask the Right Questionmentioning
confidence: 99%
“…Since these three analyzers monitor different aspects of platelet function and have different limitations, the selection of the right test system depends on the right question [35] ( Görlinger/Jambor/Hanke/Dirkmann/Adamzik/ Hartmann/Rahe-Meyer • • dynamic (with high shear stress blood flow), • static (without high shear stress blood flow).…”
Section: Ask the Right Questionmentioning
confidence: 99%
“…[1][2][3] Thus, platelet alterations are strongly associated with distinct clinical diseases, including cardiovascular diseases, diabetes, tumor metastasis, and sepsis. 4,5 In recent years, additional platelet functions have continued to come to light. Platelets can be drug targets in sepsis, and also foster cancer and rheumatoid arthritis.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, flow cytometry seems to be applicable for the assessment of the amount of transfused platelets in patients with congenital deficiencies of platelet membrane proteins [21,22]. By using fluorescence resonance energy transfer, this method seems to be capable to investigate ligand induced conformational changes of glycoproteins or interactions with other cells [23,24], but these assays are only applicable in specialized laboratories. Furthermore, flow cytometry does not provide any information about the overall haemostasis.…”
Section: Flow Cytometrymentioning
confidence: 99%