Diagnostic patterns and delays in autoimmune blistering diseases of the mouth: A cross‐sectional study

Hassona, Yazan; Cirillo, Nicola; Taimeh, Dina; Khawaldeh, H Al

doi:10.1111/odi.12839

Cited by 21 publications

(38 citation statements)

References 30 publications

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“…Due to this fact it is not always possible to relate DG to a previous diagnosis, it is important that the oral health specialists know its concept to be able to distinguish between a classic inflammatory gingivitis and DG associated to dental plaque. The magnitude of DG is based on the high delay of its pathogenic diagnosis, approximately 83.2 days (29). Because of that the physician must identify, not only the clinical description of its erythema, erosion and/or blisters presence, but it must also be accompanied by conventional microscopic study and immunofluorescence.…”

Section: Discussionmentioning

confidence: 99%

Oral hygiene instructions and professional control as part of the treatment of desquamative gingivitis. Systematic review

et al. 2019

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Background The aim of this present article was to evaluate the scientific evidence on the efficacy of daily hygiene and professional prophylaxis for treatment of desquamative gingivitis. Material and Methods The present systematic review was conducted following the PRISMA protocol. Searches were carried out in Pubmed, Embase, Web of Science and Cochrane Library up to July 2018, randomized clinical trials and cohort studies on desquamative gingivitis (DG), and oral diseases joined to DG. Results After screening, we found that nine publications met the eligibility criteria eight cohort studies and one randomized control trial. The diagnosis of the diseases corresponded to oral lichen planus (n=185), mucous membrane pemphigoid (n=13); plasma cell gingivitits (n=15) and pemphigus vulgar (n=11). The follow-up was between a week and a year after instructing patients. Dental daily hygiene and professional prophylaxis, at least with supragingival scaling and polishing have significantly improved the extension of the lesion and reduced the activity of DG, and gingival bleeding in all patients. Furthermore, these techniques have also reduced pain and gingival plaque. Conclusions In conclusion the studies presented support the efficacy of maintaining personal and professional oral hygiene in patients with GD, reducing the clinical signs of the disease, regardless of its pathogenesis. Key words: Desquamative gingivitis, oral hygiene, oral lichen planus, mucous membrane pemphigoid; pemphigus, plasma cell gingivitis.

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Section: Discussionmentioning

confidence: 99%

Oral hygiene instructions and professional control as part of the treatment of desquamative gingivitis. Systematic review

et al. 2019

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“…These immune-mediated diseases could be characterized by muco-cutaneous involvement and chronic course [4]. However, almost one third of the patients present primarily only gingival involvement in the form of DG which remains under-diagnosed for a longer time [4].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Concordance between Optical Coherence Tomography and Histological Investigations for Immune-Mediated Desquamative Gingivitis: Observational Study

Panzarella

Bartolone

Coniglio

et al. 2021

IJERPH

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Desquamative gingivitis (DG) denotes a heterogeneous immune-mediated disease for which early diagnosis represents a great challenge. The main aim of this study is to validate diagnostic concordance between specific Optical Coherence Tomography (OTC) patterns for DG related to oral Lichen Planus (OLP), Pemphigus Vulgaris (PV), and Mucous Membrane Pemphigoid (MMP) and definitive histological diagnosis. Forty-three patients with suspected immune-mediated DGs, were progressively recruited. Before biopsy, an OCT preliminary evaluation was performed using specific pre-determined OCT diagnostic patterns (i.e., morphology and localization of blisters, status of the basal membrane, epithelial thickness, presence/absence of acantholytic cells into blister and/or inflammatory infiltrate) related to OLP, PV and MMP. After histological confirmation, OCT and histological diagnoses were compared. Using pre-determined patterns, OCT diagnoses of DGs were: 22 (51%) OLP, of which 11 (26%) were with the bullous variant, 4 (9%) PV and 6 (14%) MMP. The same diagnoses were found by histological investigations (with the main OCT discriminatory potential for the bullous variant of OLP). The concordance between the two diagnostic methods was confirmed by the Fisher exact test (p-value < 0.01). These specific OCT patterns show a diagnostic reliability in 100% of the cases investigated, suggesting their accuracy to support the complex diagnosis and management of immune-mediated DGs.

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“…Por esto, no siempre es posible relacionar la DG con un diagnóstico previo, es importante que los especialistas en salud oral conozcan su concepto para poder distinguir entre una gingivitis inflamatoria clásica y una DG asociada con la placa dental. 15 El médico debe identificar no sólo la descripción clínica de su presencia de eritema, erosión y/o ampollas, sino que también debe hacer un estudio microscópico convencional e inmunofluorescencia. Este hecho requiere que el médico especialista, Este documento es elaborado por Medigraphic generalmente en patología oral, realice la biopsia en el área apropiada, con el propósito de proyectar el diagnóstico histopatológico e inmunológico de la lesión.…”

Section: Discussionunclassified

Gingivitis descamativa asociada a penfigoide de membranas mucosas

Luevanos¹,

Beltrán²,

Villalba³

et al. 2019

Revista Mexicana De Periodontología

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Caso ClíniCo RESUMEN La gingivitis descamativa asociada con penfigoide de membranas mucosas (MMP) (ICD-10 L10), es una entidad correspondiente a enfermedad gingival no relacionada con placa bacteriana, que forma parte de un grupo heterogéneo de desórdenes ampollares, autoinmunes y crónicos, que se manifiestan clínicamente como áreas con eritema sintomáticas sobre la encía, las cuales forman una bulla ante el frotamiento, lo que se conoce como Nikolsky positivo. El estudio histopatológico se caracteriza por la división sub-basal, con presencia de infiltrado inflamatorio en la lámina propia pertinente a los depósitos de proteínas del complemento e inmunoglobulinas. El examen de inmunofluorescencia directa muestra depósitos lineales de inmunoglobulinas, principalmente IgG y complemento sobre la membrana basal. Se describe un caso donde se examinó la relación entre el periodoncista y el patólogo bucal, para el diagnóstico de penfigoide de membranas mucosas.

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Diagnostic patterns and delays in autoimmune blistering diseases of the mouth: A cross‐sectional study

Cited by 21 publications

References 30 publications

Oral hygiene instructions and professional control as part of the treatment of desquamative gingivitis. Systematic review

Oral hygiene instructions and professional control as part of the treatment of desquamative gingivitis. Systematic review

Diagnostic Concordance between Optical Coherence Tomography and Histological Investigations for Immune-Mediated Desquamative Gingivitis: Observational Study

Gingivitis descamativa asociada a penfigoide de membranas mucosas

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