Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis

Pang, Shuyin; Liu, H Y; Huang, Yinghong; Liu, Y F; Dai, Yumei; Zeng, Ping; Zeng, Huasong

doi:10.4238/gmr.15028641

Cited by 8 publications

(5 citation statements)

References 32 publications

(34 reference statements)

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“…It is well-known that there is a close association between ACPA and bone destruction in RA (9). Previous studies support the significance of ACPA in inflammation-associated bone diseases, not confined to RA, but also in non-RA autoimmune conditions, and ACPA may be detected in psoriatic arthritis, systemic lupus erythematosus and juvenile idiopathic arthritis, as well as scleroderma and CREST syndrome, followed by Sjögren's syndrome and vasculitis (10)(11)(12)(13)(14)(15). However, the prevalence of ACPA positivity was higher in patients with RA than in those mentioned above apart from RA (11,12).…”

Section: Case Reportmentioning

confidence: 91%

Possible association of idiopathic pulmonary hemosiderosis with rheumatoid arthritis: A case report

Ren

Yang

et al. 2020

Exp Ther Med

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Idiopathic pulmonary hemosiderosis (IPH) is a rare interstitial lung disease, usually occurring in children or young adults. Although several studies reported on the coexistence of IPH and immune system diseases, the association between these conditions has not been well described. The present study reports on the case of a 21-year-old female patient who presented with bilateral lung abnormalities. The patient was admitted due to a 2-year history of progressive exertional dyspnea, as well as arthralgia and joint swelling in the recent 2 months. During the past 15 years, the patient had been diagnosed with anemia and received repeated blood transfusions. Serial chest CT scans indicated an interstitial pattern. On physical examination, the patient had pale skin with a hemoglobin level of 65 g/l and exhibited finger-clubbing. Arterial blood gas analysis revealed hypoxia. Anticyclic-citrullinated protein antibody and rheumatoid factor were highly positive. Pulmonary function tests revealed restrictive ventilation dysfunction and decreased diffusion capacity. Bronchoscopy and biopsy confirmed diffuse alveolar hemorrhage. Following assessment of the etiology, the diagnosis of IPH was made by exclusion. The patient's symptoms and laboratory findings combined also confirmed the diagnosis of rheumatoid arthritis (RA). After receiving corticosteroid treatment, the patient's condition improved, and she was discharged and followed up. Based on this patient and a review of the literature, the present study demonstrated for the first time that IPH may mediate the development of an RA pathology. Therefore, early diagnosis is important for the timely management of IPH, which may also delay or even prevent the development of immune system diseases, e.g. RA, in patients with IPH. Further attention should be paid to determine the association between IPH and immune system diseases in the clinical setting.

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Section: Case Reportmentioning

confidence: 91%

Possible association of idiopathic pulmonary hemosiderosis with rheumatoid arthritis: A case report

Ren

Yang

et al. 2020

Exp Ther Med

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“…The presence of anti-CCPs was determined by chemiluminescence using a thirdgeneration commercial anti-CCP test (Abbott, IL, USA) and processed in an Abbott Architect Plus autoanalyzer. When the concentration was ≥20 IU/mL, samples were considered positive [18,19].…”

Section: Anti-cyclic Citrullinated Peptide Antibodies (Anti-ccps)mentioning

confidence: 99%

Clinical, Immunological and Inflammatory Characteristics among Mexican Children with Different Subtypes of Juvenile Idiopathic Arthritis: Exploring the Correlation between Anti-Cyclic Citrullinated Peptide (anti-CCP) and Rheumatoid Factor (RF)

Hernández-Huirache,

Armenta-Medina,

Rodea-Montero

2024

Pediatric Reports

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Introduction: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood, affecting one to four of every 1000 children worldwide. It is characterized by joint inflammation lasting more than six weeks in children under 16 years. The aim of this study was to estimate the frequency of JIA subtypes in the Mexican patient population; compare clinical, immunological and inflammation markers by JIA subtype; and examine the correlation between these variables. Methods: We conducted a cross-sectional study of 50 patients with JIA (2–15 years). We estimated the frequency of each JIA subtype, assessed and compared the immunological characteristics (RF, ANA and anti-CCP) by JIA subtype at the time of diagnosis using Kruskal–Wallis or chi-square tests, and calculated Spearman correlation coefficients between the assessments. Results: Our analysis included 50 patients, 29 (58%) girls and 21 (42%) boys, aged at the time of diagnosis 10.56 ± 3.99 years. The frequencies of JIA subtypes were RF-seropositive polyarthritis (34%), RF-seronegative polyarthritis (28%), systemic arthritis (16%), oligoarthritis (14%) and arthritis-related enthesitis (8%). We found a significant association between sex and JIA subtype (p = 0.014). There was a significant difference in anti-CCP levels by JIA subtype (p < 0.001). We also detected positive correlations between RF and anti-CCP (r = 0.63, p < 0.001) and between age and anti-CCP (r = 0.29, p = 0.041). Conclusions: Our study suggests that the frequency of the polyarticular subtypes of JIA is higher in Mexican children compared to other populations. Our findings highlight the importance of considering the presence of anti-CCP and RF as important criteria when deciding on treatment for JIA patients as elevated levels of these antibodies may indicate early forms of adult rheumatoid arthritis.

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“…W badaniach wykazano, że obecność anty-CCP w wielostawowym MIZS z dodatnim wynikiem RF zwiększa ryzyko rozwinięcia agresywnej postaci choroby. Podobnie jak w przypadku RF, anty-CCP dodatni wynik u dzieci z wielostawowym MIZS skłania reumatologów dziecięcych do zalecenia wcześniejszej, bardziej intensywnej terapii (Pang i współaut. 2016).…”

Section: Wybrane Autoprzeciwciałaunclassified

Znaczenie diagnostyki laboratoryjnej w młodzieńczym idiopatycznym zapaleniu stawów

Strączyńska

2023

Kosmos

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Młodzieńcze idiopatyczne zapalenie stawów należy do najczęstszych zaburzeń reumatologicznych wieku dziecięcego, które dotyka około 1 na 1000 dzieci do 16 roku życia i dlatego stanowi istotny problem kliniczny w pediatrii. Jest to choroba o podłożu autoimmunologicznym o nieznanej etiopatogenezie, co oznacza, że wraz z nieprawidłową odpowiedzią układu odpornościowego, organizm zaczyna niszczyć komórki tkanki (głównie w stawach) bez wyraźnej przyczyny. W przebiegu MIZS wykładnikiem toczących się procesów autoimmunologicznych jest obecność różnych przeciwciał w surowicy oraz płynie stawowym. Oznaczanie niektórych z nich znalazło zastosowanie w diagnostyce klinicznej takich jak czynnik reumatoidalny, przeciwciała ANA, czy przeciwciała anty-CCP. Diagnostyka kliniczna MIZS opiera się na objawach klinicznych połączonych z badaniem autoprzeciwciał. W powyższej pracy przedstawiono przegląd klasycznie stosowanych testów używanych do diagnostyki MIZS. Istnieje potrzeba badań naukowych, aby pomóc zrozumieć złożoność procesu zapalnego i umożliwić opracowanie terapii, które mogłyby pomóc wielu pacjentom w wyleczeniu choroby i poprawie jakości życia.

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Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis

Cited by 8 publications

References 32 publications

Possible association of idiopathic pulmonary hemosiderosis with rheumatoid arthritis: A case report

Possible association of idiopathic pulmonary hemosiderosis with rheumatoid arthritis: A case report

Clinical, Immunological and Inflammatory Characteristics among Mexican Children with Different Subtypes of Juvenile Idiopathic Arthritis: Exploring the Correlation between Anti-Cyclic Citrullinated Peptide (anti-CCP) and Rheumatoid Factor (RF)

Znaczenie diagnostyki laboratoryjnej w młodzieńczym idiopatycznym zapaleniu stawów

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