Diagnostic performance of coagulation indices for direct oral anticoagulant concentration

Zhang, Hanxu; Liu, Zhiyan; Mu, Guangyan; Wang, Zhe; Zhou, Shuang; Xie, Qiufen; Ma, Lei; Wang, Zining; Hu, Kun; Gong, Yanjun; Jiang, Jie; Xiang, Qian; Chen, Yimin

doi:10.1016/j.thromres.2020.07.031

Cited by 10 publications

(5 citation statements)

References 40 publications

(88 reference statements)

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“…For example, monitoring may be beneficial in patients with very high or low body mass indexes, or with renal impairment. 41 , 42 Many consider DOACs to be advantageous because regular monitoring is not needed, but for certain patients with nonadherence, monitoring might serve to boost confidence in the effect of DOACs and increase adherence. Patient knowledge about the existence of reversal agents, the frequency of physician communication about these agents, and the influence of knowledge about the agents on adherence requires additional exploration, as does the relationship of these interventions on patient adherence.…”

Section: Discussionmentioning

confidence: 99%

Reasons for Nonadherence to the Direct Oral Anticoagulant Apixaban

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Reasons for Nonadherence to the Direct Oral Anticoagulant Apixaban

et al. 2023

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“…According to the pharmacokinetic characteristics, the trough concentration time of dabigatran and rivaroxaban was within 1 hour before the next administration, and the peak concentration time was 3 hours after the next administration. Blood samples were collected according to the above time [9,10] . AXA applied uorescence method, Werfen ACL-TOP-700 instrument, Werfen AXA reagent determination and record.…”

Section: Methodsmentioning

confidence: 99%

Clinical Features and Follow-up Outcomes of Individualized Low-dose DOAC Therapy in Chinese Patients Aged 60 Years and Older: A Single-center Study

Zhang,

Du,

Liu

2024

Preprint

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Introduction: It is common to adjust direct oral anticoagulant (DOAC) dosage individually according to the clinical characteristics and coagulation indexes of patients in clinical practice, but its effectiveness and safety are still controversial. The purpose of this study was to analyze the clinical characteristics and follow-up outcomes of elderly patients who adjusted anticoagulant therapy according to coagulation index. Method: Included were patients who were admitted to the geriatric Department of Peking University First Hospital from January 1, 2016 to December 31, 2021, with indications of anticoagulation therapy, receiving DOAC (Dabigatran, Rivaroxaban) therapy, individualized dose adjustment according to APTT (peak value of 46-60s) or AXA (peak value of 0.5-1.0IU/ml), aged ≥60 years, and complete clinical data. Outpatient or telephone follow-up every three months after discharge until termination or death or end of study (December 31, 2022). The clinical features and follow-up results of Dabigatran 110mg BID group and Dabigatran 110mg QD group, Rivaroxaban 5mg BID group and Rivaroxaban 2.5mg BID group were compared. Result: A total of 388 patients were enrolled, including 145 (35.1%) in the Dabigatrangroup and 243 (58.8%) in the rivaroxaban group. The Dabigatrangroup was divided into the 110mg BID group (85 cases) and the 110mg QD group (60 cases), and patients in the 110mg QD group were older, lighter, and had lower glomerular filtration rate (eGFR). The Rivaroxaban group was divided into the 5mg BID group (134 cases) and the 2.5mg BID group (109 cases), and patients in the 2.5mg BID group were older, weighed less, had lower activity of daily living (ADL) scores, and had lower eGFR. The mean follow-up time was 49.5±23.4 months in the Dabigatrangroup and 32.1±20.1 months in the Rivaroxaban group. Survival analysis of bleeding events, thrombotic events, and death was not significantly different between Dabigatran 110mgBID and 110mgQD and Rivaroxaban 5mgBID and 2.5mgBID groups. Conclusion: The clinical characteristics of patients with individualized low-dose DOAC regimen were as follows: age ≥80 years old, weight ≤60kg, ADL score ≤60 points, HAS-BLED score ≥3 points, eGFR < 60ml/min/1.73m², baseline hemoglobin < 120g/L. There was no significant difference in the incidence of bleeding and thrombotic events between individualized low-dose therapy based on patient clotting indicators and standard therapy.

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“…In addition, the aggregate properties were found not to influence the bonding strength when the cohesive failure occurred. Moreover, some studies have shown that asphalt is a selfhealing material, with these properties being directly affected by factors such as temperature [19][20][21]. García explained the 2 Advances in Materials Science and Engineering changes in the self-healing rates of asphalt mixture with temperature using the Arrhenius equation and found that there is a minimum temperature below which asphalt cannot be healed [22].…”

Section: Literature Reviewmentioning

confidence: 99%

Influence of Aggregate and Asphalt Type on the Bond Strength between Asphalt and Aggregates and Its Self-Healing Properties

Gan

Zhang

Li³

et al. 2022

Advances in Materials Science and Engineering

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Determining the bond strength between asphalt and the aggregate base material is an intuitive way to ascertain the adhesion. In this study, we determined the bond strength between different types of asphalt and aggregates. First, the influence of these types of asphalt and aggregates on the bond strength was evaluated. Second, the bond strength of lime aggregate-based material and five types of asphalt in dry and immersion states was measured, and the influence of water on the bond strength was investigated. Third, the asphalt was extracted into aromatic, saturated, colloidal, and asphaltene by an asphalt component separation test, and the bond strength between each asphalt component and aggregate was tested. Finally, for the specimens with adhesive failure, the bond strength was retested to evaluate the self-healing ability of the adhesive. The results show that adhesion is influenced by asphalt and aggregate types as well as water immersion. The adhesion between asphalt and aggregate is primarily gum-based, followed by aromatics. After adhesion failure, the adhesion recovers to a certain extent (that is, it self-heals), but the healing rate decreases with the increase in test frequency; the adhesion tends to be stable after the third test.

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Diagnostic performance of coagulation indices for direct oral anticoagulant concentration

Cited by 10 publications

References 40 publications

Reasons for Nonadherence to the Direct Oral Anticoagulant Apixaban

Reasons for Nonadherence to the Direct Oral Anticoagulant Apixaban

Clinical Features and Follow-up Outcomes of Individualized Low-dose DOAC Therapy in Chinese Patients Aged 60 Years and Older: A Single-center Study

Influence of Aggregate and Asphalt Type on the Bond Strength between Asphalt and Aggregates and Its Self-Healing Properties

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