Diagnostic performance of different specimens in detecting enterovirus A71 in children with hand, foot and mouth disease

Zhou, Yonghong; Zhou, Chunmei; Wang, Kai; Qiu, Qi; Cheng, Yibing; Liu, Yu; Cui, Peng; Liang, Lu; Deng, Xiaowei; Wang, Lili; Zheng, Wen; Gong, Hui; Wang, Fang; Xu, Meng; Chu, Justin Jang Hann; Turtle, Lance; Yu, Hongjie

doi:10.1016/j.virs.2022.11.004

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…However, it did not assess the viral diagnostic performance of stool samples. In our study, we revealed that stool samples had the highest detection rate of EV, consistent with previous study indicating that stool samples have the highest diagnostic yield for EV infection in various paediatric specimens [ 26 ]. Therefore, using stool EV-PCR testing as a diagnostic adjunct can rapidly identify young infants admitted with suspected EV, offering the added advantages of convenient collection and noninvasiveness.…”

Section: Discussionsupporting

confidence: 91%

Emergence and circulation of enterovirus B species in infants in southern China: A multicenter retrospective analysis

Yang,

Wu,

Zhao

et al. 2024

Virulence

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Background Enteroviruses (EV) are common and can cause severe diseases, particularly in young children. However, the information of EV infection in infants in China is limited due to the vast population size and extensive geographical area of the country. Here, we conducted a retrospective multicenter analysis of available EV data to assess the current epidemiological situation in the infant population in southern China. Methods The study enrolled infants with suspected EV infection from 34 hospitals across 12 cities in southern China between 2019 to 2022, and the confirmation of EV was done using RT-PCR and VP1 gene sequencing. Results Out of 1221 infants enrolled, 330 (27.03%) were confirmed as EV-infected. Of these, 260 (78.79%) were newborns aged 0–28 days. The EV belonged to three species: EV-B (80.61%), EV-A (11.82%), and human rhinovirus (7.58%). Newborns were more susceptible to EV-B than older infants ( p < 0.001). Within EV-B, we identified 15 types, with coxsackievirus (CV) B3 (20.91%), echovirus (E) 11 (19.70%), and E18 (16.97%) being the most common. The predominant EV types changed across different years. EV infection in infants followed a seasonal pattern, with a higher incidence from May to August. Furthermore, perinatal mother-to-child EV transmission in 12 mother-newborn pairs were observed. Conclusion Our study is the first to demonstrate the emergence and widespread circulation of EV-B species, mainly CVB3, E11, and E18, in southern China, primarily affecting young infants. This research provides valuable insights for future epidemic assessment, prediction, as well as the elimination of mother-to-child transmission.

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Section: Discussionsupporting

confidence: 91%

Emergence and circulation of enterovirus B species in infants in southern China: A multicenter retrospective analysis

Yang,

Wu,

Zhao

et al. 2024

Virulence

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“…Patients are advised to rest, stay hydrated and drink clean, filtered water. Ibuprofen or acetaminophen can be used to provide relief from body pain and fever [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

‘Tomato flu’ a new epidemic in India: Virology, epidemiology, and clinical features

Ismail

Saahath

Ismail

et al. 2023

New Microbes and New Infections

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“…Moreover, hydration therapy and drinking filtered water are suggested to the patients for faster recovery. Acetaminophen or ibuprofen was found effective in treating fever and body aches [4] .…”

Section: Dear Editormentioning

confidence: 99%

Tomato flu: need to look beyond the frame

Kumar

Patel²,

Rana

et al. 2023

International Journal of Surgery: Global Health

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Diagnostic performance of different specimens in detecting enterovirus A71 in children with hand, foot and mouth disease

Cited by 4 publications

References 31 publications

Emergence and circulation of enterovirus B species in infants in southern China: A multicenter retrospective analysis

Emergence and circulation of enterovirus B species in infants in southern China: A multicenter retrospective analysis

‘Tomato flu’ a new epidemic in India: Virology, epidemiology, and clinical features

Tomato flu: need to look beyond the frame

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