Diagnostic performance of fluorodeoxyglucose-positron emission tomography/computed tomography of breast cancer in detecting axillary lymph node metastasis: comparison with ultrasonography and contrast-enhanced CT

Monzawa, Shuichi; Adachi, Shuji; Suzuki, Kayo; Hirokaga, Koichi; Takao, Shintaro; Sakuma, Takashi; Hanioka, Keisuke

doi:10.1007/s12149-009-0314-9

Cited by 29 publications

(24 citation statements)

References 33 publications

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“…The sensitivity of only 38% for the detection of axillary lymph node metastases with ultrasound is lower compared to some sensitivities reported in the literature: Ueda et al, for example, reported a sensitivity of 54% (10); Ahn et al even reported a sensitivity of 79.5% (30). Monzawa et al, however, reported a sensitivity of only 33% (31); the difference between our sensitivity and the high sensitivities reported in the literature be a result of the course of action with axillary ultrasound: although a senior senologist supervised all ultrasound investigations performed not by himself some lymph node metastases may be missed as it is a known limitation of ultrasound's accuracy to be strongly investigator dependent. This might have artificially deteriorated the sensitivity of ultrasound.…”

Section: Discussioncontrasting

confidence: 90%

Comparison of the Diagnostic Value of FDG-PET/CT and Axillary Ultrasound for the Detection of Lymph Node Metastases in Breast Cancer Patients

et al. 2012

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Section: Discussioncontrasting

confidence: 90%

Comparison of the Diagnostic Value of FDG-PET/CT and Axillary Ultrasound for the Detection of Lymph Node Metastases in Breast Cancer Patients

et al. 2012

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“…Previous reports showed a positive correlation between the sensitivity of PET and the number of histopathologically positive lymph nodes [12, 16, 26, 28, 29]. Others reported that the sensitivity of PET was positively related to the FDG avidity of primary tumors [28,29].…”

Section: Discussionmentioning

confidence: 99%

“…Visual assessment [6, 9, 10, 12] and semiquantitative analysis with standardized uptake value (SUV) cutoffs that ranged between 1.8 and 2.5 [7-9, 14] were used to differentiate benign from malignant lymph nodes. However, to our knowledge, no data have been published on definitive SUV cutoffs for regional nodal metastasis in patients with IBC.…”

Section: Introductionmentioning

confidence: 99%

Semiquantitative Analysis of Maximum Standardized Uptake Values of Regional Lymph Nodes in Inflammatory Breast Cancer

et al. 2012

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Rationale and Objectives Our objective is to determine an optimum standardized uptake value (SUV) threshold for identifying regional nodal metastasis on 18 fluoro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) studies of patients with inflammatory breast cancer (IBC). Materials and Methods A database search was performed of newly diagnosed IBC patients who had 18F-FDG PET/CT performed at the time of diagnosis in a single institution between January 1, 2001 and September 30, 2009. Three radiologists blinded to the histopathology of the regional lymph nodes retrospectively analyzed all 18F-FDG PET/CT images by measuring the SUVmax in visually abnormal nodes. The accuracy of 18F-FDG PET/CT image interpretation was correlated with histopathology where available. A receiver operating characteristic curve (ROC) analysis was performed to assess the diagnostic performance of PET/CT. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated using 3 different SUV cutoff values (2.0, 2.5, 3.0). Results A total of 888 regional nodal basins, including bilateral axillary, infraclavicular, internal mammary and supraclavicular lymph nodes were evaluated in 111 patients with a mean age of 56 years. Of the 888 nodal basins, 625 (70%) were negative and 263 (30%) were positive for metastasis. Malignant lymph nodes had significantly higher SUVmax than benign lymph nodes (p <0.0001). An SUVmax of 2.0 showed the highest overall sensitivity (89%) and specificity (99%) for the diagnosis of malignant disease. Conclusion SUVmax of regional lymph nodes on 18F-FDG PET/CT may help differentiate benign and malignant lymph nodes in IBC patients. SUV cutoff 2 provided the best accuracy in identifying regional nodal metastasis in this patient population.

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“…CECT remains a cost-effective means to assess the status of axillary lymph nodes among patients with breast cancer despite the progress of positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) [16, 17]. Beginning in January 2008, most surgeons in our institution gradually adopted preoperative CECT for assessment of axillary lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Contrast enhanced computed tomography is indicative for angiogenesis pattern and display prognostic significance in breast cancer

Zhang

et al. 2014

BMC Cancer

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BackgroundThe Prognostic value of microvessel density in cancer remains unclear. Recent studies have suggested that the uneven distribution of microvessels in tumours caused the variation in sample selection which led to different prognostic outcome. The enhancement pattern of Contrast-enhanced computed tomography (CECT) is determined in part by the microvessel distribution in solid tumors. Therefore, survival analysis of tumors grouping by the enhancement pattern and the pattern of microvessel distribution is important.MethodsSurvival analysis grouped by the tumor enhancement pattern and the microvessel distribution was carried out in 255 patients with invasive ductal carcinoma.ResultsThere were significant differences in overall survival (OS) and disease-free survival (DFS) among the homogeneous, heterogeneous and peripheral enhancement groups. There were significant differences between OS and DFS groups with uniform and uneven distributions of microvessels.ConclusionsThe distribution of microvessels in a tumor is a potential prognostic indicator in patients with breast cancer, and can be assessed by CECT prior the operation.

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Diagnostic performance of fluorodeoxyglucose-positron emission tomography/computed tomography of breast cancer in detecting axillary lymph node metastasis: comparison with ultrasonography and contrast-enhanced CT

Abstract: PET/CT showed poor sensitivity and high specificity in the detection of axillary lymph node metastasis of breast cancer. Diagnostic performance of PET/CT was not superior to that of ultrasonography and contrast-enhanced CT.

Cited by 29 publications

References 33 publications

Comparison of the Diagnostic Value of FDG-PET/CT and Axillary Ultrasound for the Detection of Lymph Node Metastases in Breast Cancer Patients

Comparison of the Diagnostic Value of FDG-PET/CT and Axillary Ultrasound for the Detection of Lymph Node Metastases in Breast Cancer Patients

Semiquantitative Analysis of Maximum Standardized Uptake Values of Regional Lymph Nodes in Inflammatory Breast Cancer

Contrast enhanced computed tomography is indicative for angiogenesis pattern and display prognostic significance in breast cancer

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