Diagnostic performance of <i>Echinococcus granulosus</i> protoscolices antigens in the serodiagnosis of human cystic echinococcosis

Shahabinejad, Pardis; Shahriarirad, Reza; Omidian, Mostafa; Ghorbani, Fariba; Barazesh, Afshin; Sarkari, Bahador

doi:10.1080/15321819.2020.1781653

Cited by 7 publications

(7 citation statements)

References 23 publications

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“…Our center is based among the locations considered endemic for cystic echinococcosis. The disease should be adequately managed before presenting any further complications, such as superinfections or, in our case, fistula 18–21 . Although BBF in many patients is not considered fatal, intraoperative and post‐operative deaths have been reported 5,22 .…”

Section: Discussionmentioning

confidence: 92%

“…The disease should be adequately managed before presenting any further complications, such as superinfections or, in our case, fistula. 18 , 19 , 20 , 21 Although BBF in many patients is not considered fatal, intraoperative and post‐operative deaths have been reported. 5 , 22 Our patients' outcomes were excellent, and symptoms resolved after surgery.…”

Section: Discussionmentioning

confidence: 99%

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Bronchobiliary fistulae as a complication of untreated pulmonary hydatid cyst presenting with bilioptysis: A report of two cases

Mardani

Kamran

Khosravi

et al. 2023

Clinical Case Reports

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Cystic echinococcosis (CE) is a universal endemic larval infection that mainly involves the lung and liver 1,2 but can occur in various organs. 3 Bronchobiliary fistulae (BBF) is a highly uncommon complication of untreated hydatid cyst, and patients mainly present with bilioptysis. 4 Clinical manifestation of bilioptysis can attain the diagnosis of BBF, and therapeutic options may include surgical or safer non-surgical modalities. 5 We presented two patients with lung and liver hydatid cysts with BBF. In the current report, we share our experience treating this rare entity. | CASE PRESENTATION | Case 1A 45-year-old lady was admitted to our hospital due to dyspnea, fever, productive cough, and green sputum

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Bronchobiliary fistulae as a complication of untreated pulmonary hydatid cyst presenting with bilioptysis: A report of two cases

Mardani

Kamran

Khosravi

et al. 2023

Clinical Case Reports

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“…Furthermore, searching for serum or hydatid fluid antigens is a useful method in the diagnosis process [ 25 ]. In CE, these antigens include hydatid protoscolices antigen (HPA), B antigen, B-rich antigen solution (BRAS), and crude antigen (CA) [ 26 ]. Furthermore, a broad range of antigens has also been identified in the case of AE, such as Em2, Em492, and Em18 [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Basic Operative Tactics for Pulmonary Echinococcosis in the Era of Endostaplers and Energy Devices

et al. 2023

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Human echinococcosis is a zoonotic infection caused by the larvae of the tapeworm species Echinococcus. The liver is the most common location for a primary echinococcosis. However, the parasite may bypass or spread from the liver to the lungs, causing primary or secondary pulmonary echinococcosis, respectively. Pulmonary echinococcosis is a clinically challenging condition in which anthelminthic regiments are important, but surgery has the central role in removing the cysts and preventing recurrences. Surgical treatment may involve cystotomy, enucleation, capitonnage, or atypical resections, which occasionally are in combination with hepatic procedures. The utilization of modern devices is greatly underdescribed in surgery for thoracic infections, even though these facilitate much of the work. Therefore, this article aims to describe pulmonary echinococcosis and the role of modern surgical devices in the treatment process. Furthermore, we report surgical treatment of three different cases of pulmonary echinococcosis. Surgeries of uncomplicated and ruptured hepatic or pulmonary cysts are described. Simple small pulmonary echinococcal lesions can be excised by endostaplers both for diagnostic and curative reasons. Larger cysts can be removed by energy devices unless large bronchial air leaks occur. Complicated cysts require treatment by more extensive techniques. Inexperienced surgeons should not abstain but should carefully decide preoperatively how to proceed.

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“…27 The antigens prepared from protoscolices of hydatid cyst are suitable for the serological diagnosis of human CE with a sensitivity of 93%. 28 The positive circulating protoscolices antigen indicates active infection and turns negative in patients treated by surgical removal or chemotherapy. 29 The ELISA yields the best performance as a diagnostic method for the detection of the metacestode antigen.…”

Section: Discussionmentioning

confidence: 99%

Conjugated silver nanoparticles as a diagnostic tool for circulating hydatid antigens

Shakra

Abou-Sheishaa

Hafez

et al. 2022

EJI

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Cystic hydatid disease is one of the most significant worldwide zoonotic diseases. The causative agent is the larval stage of Echinococcus granulosus. The diagnosis of cystic echinococcosis by clinical symptoms and scanning alone is often difficult and confusing. The definite diagnosis needs sensitive and reliable serological tests. This study aimed to evaluate a nano silver-based enzyme linked immunosorbent assay (ELISA) in the detection of circulating hydatid antigen in human serum samples. The study included 66 human serum samples (36 hydatidosis confirmed cases, 15 cases infected with other parasites, and 15 normal subjects as negative control). The circulating protoscolices antigen was assayed by the nano-silver dot ELISA, nano-silver sandwich ELISA and the traditional methods (dot ELISA and sandwich ELISA). Our study revealed that the sensitivity and specificity of the nano-silver dot ELISA were 97.2% and 93.3%, respectively. The sensitivity and specificity of nano-silver sandwich ELISA were 94.4% and 96.7% respectively. The nano-silver-based ELISA showed higher sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy than the traditional ELISA. In conclusion, the nano-silver-based ELISA can be proposed as a confirmatory test in the diagnosis of cystic echinococcosis.

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Diagnostic performance of Echinococcus granulosus protoscolices antigens in the serodiagnosis of human cystic echinococcosis

Cited by 7 publications

References 23 publications

Bronchobiliary fistulae as a complication of untreated pulmonary hydatid cyst presenting with bilioptysis: A report of two cases

Bronchobiliary fistulae as a complication of untreated pulmonary hydatid cyst presenting with bilioptysis: A report of two cases

Basic Operative Tactics for Pulmonary Echinococcosis in the Era of Endostaplers and Energy Devices

Conjugated silver nanoparticles as a diagnostic tool for circulating hydatid antigens

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