Diagnostic Performance of IgE Anti-Der p 10 to Identify Patients with Shrimp Allergy

Abstract

<b><i>Background:</i></b> Patients with allergic rhinitis to house dust mites have an increased risk of shrimp allergy. Der p 10 is a candidate biomarker to predict the risk of shrimp allergy among allergic rhinitis patients. <b><i>Objectives:</i></b> The aim of this study was to evaluate the diagnostic performance of anti-Der p 10 IgE as a predictor of shrimp allergy. <b><i>Methods:</i></b> A nested case-control study was carried out with eighty-six allergic rhinitis patients sensitized to mite (<i>Dermatophagoides pteronyssinus</i>) and shrimp (<i>Litopenaeu vannamei</i>). Cases and controls were defined by anti-Der p 10 IgE results. Oral challenge with shrimp was used as the gold standard for the evaluation of diagnostic performance. <b><i>Results:</i></b> All shrimp oral challenge test (OCT)-positive patients were positive for IgE against Der p 10. The level of anti-Der p 10 IgE >1.2 kUA/mL had the best diagnostic performance (sensitivity 100%, specificity 65%) <b><i>Conclusion:</i></b> Anti-Der p 10 IgE is useful for predicting shrimp allergy diagnosis and could reduce the requirement of an OCT.