Diagnostic Performance of Initial Salivary Alpha-Amylase Activity for Acute Myocardial Infarction in Patients with Acute Chest Pain

Shen, Ying-Sheng; Chen, Wei-Lung; Chang, Hsin-Yu; Kuo, Hung-Yi; Chang, Yue‐Cune; Chu, Hsin

doi:10.1016/j.jemermed.2011.06.040

Cited by 27 publications

(17 citation statements)

References 33 publications

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“…Moreover, salivary amylase reflected not only stress from chest pain, but also the effects of AMI itself on the autonomic nervous system. As such, the findings indicate that salivary amylase can be useful as a novel diagnostic biomarker for AMI 21) . Ahmed et al 22) conducted a study on 58 adult ischemic stroke patients within 24 hours of onset, monitoring BP and salivary cortisol for 24 hours.…”

Section: Discussionmentioning

confidence: 74%

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Response of Salivary Stress Markers in Conscious and Unconscious Patients with Acute Ischemic Stroke

Shinohara

Shiraishi

Hasegawa

2016

J St. Marianna Univ

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Background and Purpose: Several salivary markers have been utilized to evaluate acute or chronic psychological stress in various conditions. However, the clinical utility of these biomarkers in acute stroke patients remains uncertain. The aim of this study was to investigate changes in salivary stress markers related to acute stroke, both in conscious and unconscious patients, to assess the feasibility of using salivary stress markers in acute stroke patients. Subjects and Methods: A total of 27 patients with acute ischemic stroke (AIS) as shown on diffusion magnetic resonance imaging (MRI) (mean age, 67.7 ± 12.9 years; 19 males, 70.4%) and 11 control subjects were studied. Saliva was collected from patients with AIS within 24 hours after onset (Day-1), followed by serial collection at Day-4 and Day-7 using a polymer roll saturation method. Salivary concentrations of immunoglobulin A (IgA), cortisol, alpha-amylase, and dehydroepiandrosterone (DHEA) were measured by the enzyme-linked immunosorbent assay. The patients were divided into two groups based on their level of consciousness as evaluated by the National Institutes of Health Stroke Scale (NIHSS) on admission: the alert group (n=20) and the unconscious group (n=7). Motor activity on Day-1 was classified into three categories: in bed, sitting out of bed, and higher motor activity. A multiple linear regression model was used to determine independent factors associated with changes in salivary stress markers. Results: Salivary IgA and cortisol in patients with AIS at Day-1 were significantly higher than in controls (p=0.004 in IgA; p=0.002 in cortisol), and salivary amylase at Day-1 was significantly lower (p=0.049). Salivary IgA was significantly correlated with the NIHSS score (r=0.534, p=0.004) and with initial infarct volume as determined by diffusion MRI (r=0.606, p=0.001). There were no significant serial changes in any of the salivary stress markers. Multiple linear regression analyses demonstrated that motor activity levels in patients without consciousness disturbance was significantly associated with salivary IgA levels. Conclusions:This exploratory study demonstrated the potential utility of salivary IgA in acute ischemic stroke patients. Further studies are warranted to explore the relationship between salivary IgA and the impact of psychological stress on acute ischemic stroke patients.

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Section: Discussionmentioning

confidence: 74%

“…In a study on 473 adults brought to the hospital within four hours of developing chest pain, Shen et al 21) compared salivary amylase levels between patients with and without acute myocardial infarction (AMI). It was consequently discovered that salivary amylase was significantly higher in the AMI group compared to that in the non-AMI group.…”

Section: Discussionmentioning

confidence: 99%

Response of Salivary Stress Markers in Conscious and Unconscious Patients with Acute Ischemic Stroke

Shinohara

Shiraishi

Hasegawa

2016

J St. Marianna Univ

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“…Tükrük alfa amilazının birçok fizyolojik ve psikolojik stres durumunu gösteren bir belirteç olduğu gösterildi 59 . Sonuç olarak akut miyokard infarktüslü hastalarda ağrının ve akut stresin sempatik sinir sistemini aktive ettiği ve tükrük alfa amilaz düzeyinde artışla sonuçlanan tükrük bezi adrenoseptör akvitasyonuna neden olduğu saptandı 57 .…”

Section: Akut Koroner Sendromunclassified

“…Acil servise göğüs ağrısı nedeniyle başvuran hastalarda tükrük alfa amilazının en iyi kestirim değeri 197.7 UI/L olarak saptandı 57 .…”

Section: Akut Koroner Sendromunclassified

Hiperamilazemi

Koçer

Avcı

Gülen

2017

Arşiv Kaynak Tarama Dergisi

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Amylase is measured with a rapid, easy and cheap laboratory test which is usually used in the differential diagnosis of the patients with abdominal pain. In addition to pancreatitis amilaz may increase in gastrointestinal, gynecologic, renal, cardiovascular and neurologic diseases so clinical situation of the patient should be assesed. In this article we intended to contribute clinicians knowledge about differential diagnosis of the patients with hyperamylasemia and pathogenesis of hyperamylasemia with current informations. Key words: Emergency, hyperamylasemia, drug ÖZ Amilaz karın ağrısı olan hastaların ayırıcı tanısında sıklıkla kullanılan, hızlı, ucuz, basit bir laboratuvar testi aracılığıyla ölçülür. Pankreatitin yanı sıra gastrointestinal, jinekolojik, renal, kardiyovasküler, nörolojik nedenli birçok hastalıkta da yükselebilmesi nedeniyle amilaz yüksekliği saptanan hastaların klinik durumu da mutlaka değerlendirmeye alınmalıdır. Bu yazıda hekimlerin hipermamilazemi saptadıkları hastalarda ayırıcı tanıda yer alması gereken hastalıklara ve hiperamilazemi patogenezine güncel bilgilerle katkıda bulunmak amaçlanmıştır. Anahtar kelimeler: Acil, hiperamilazemi, ilaç GirişAmilaz acil servislerde ve diğer kliniklerde karın ağrısıyla gelen hastaların değerlendirmesinde sık kullanılan bir laboratuvar testidir. Pankreatit tanısında tanı kriterleri arasında yer almasına rağmen ekstrapankreatik dokulardan da salınabilmesi nedeniyle kardiyovasküler, renal,

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“…In addition, the former changes appeared unrelated to sympathetic nervous system activity. On the contrary, in emergency setting high sAA activity is an independent predictor of acute myocardial infarction in patients presenting to the ED with chest pain and it is also associated with increased risk of malignant VA and predicts shortterm prognosis in patients with ST-Elevation Myocardial Injury [68,69]. Larger studies are needed in order to clarify its clinical use.…”

Section: Salivary α-Amylase (Saa)mentioning

confidence: 99%

Perspectives of Autonomic nervous system perioperative monitoring –focus on selected tools

2015

Int Arch Med

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Autonomic nervous system's role as a "life-sustaining" system is well known. However, the anatomical and functional complexity of ANS, makes difficult its monitoring in perioperative setting. Various methods have been proposed for measuring its activity. The current review focuses on selected tools-electrodermal activity, pupilometry, heart rate variability, surgical skin index and salivary-a amylase-and their application in the field of anesthesia, intensive care and emergency medicine.

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Diagnostic Performance of Initial Salivary Alpha-Amylase Activity for Acute Myocardial Infarction in Patients with Acute Chest Pain

Cited by 27 publications

References 33 publications

Response of Salivary Stress Markers in Conscious and Unconscious Patients with Acute Ischemic Stroke

Response of Salivary Stress Markers in Conscious and Unconscious Patients with Acute Ischemic Stroke

Hiperamilazemi

Perspectives of Autonomic nervous system perioperative monitoring –focus on selected tools

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