Diagnostic Performance of Intestinal Fusobacterium nucleatum in Colorectal Cancer

Peng, Bojian; Cao, Chuang‐Yu; Li, Wei; Zhou, Yongjian; Zhang, Yuan; Nie, Yongzhan; Cao, Yanwen; Li, Yuyuan

doi:10.4103/0366-6999.232814

“…The most persuasive epidemiological evidence of bacterial oncogenic potential, aside from H. pylori, concerns S. Typhi. However, the evidence for S. bovis and C. pneumoniae and Fusobacterium nucleatum is less conclusive, a meta-analysis on the association of those organisms with increased risk of cancer have shown either different or weak associations (33,(37)(38)(39)(40)(41)(42).…”

Section: The Human Microbiome and Cancer An Overviewmentioning

confidence: 99%

The Oral Microbiome and Cancer

Irfan

¹

,

Delgado

²

,

Frias-Lopez

³

2020

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There is mounting evidence that members of the human microbiome are highly associated with a wide variety of cancer types. Among oral cancers, oral squamous cell carcinoma (OSCC) is the most prevalent and most commonly studied, and it is the most common malignancy of the head and neck worldwide. However, there is a void regarding the role that the oral microbiome may play in OSCC. Previous studies have not consistently found a characteristic oral microbiome composition associated with OSCC. Although a direct causality has not been proven, individual members of the oral microbiome are capable of promoting various tumorigenic functions related to cancer development. Two prominent oral pathogens, Porphyromonas gingivalis, and Fusobacterium nucleatum can promote tumor progression in mice. P. gingivalis infection has been associated with oro-digestive cancer, increased oral cancer invasion, and proliferation of oral cancer stem cells. The microbiome can influence the evolution of the disease by directly interacting with the human body and significantly altering the response and toxicity to various forms of cancer therapy. Recent studies have shown an association of certain phylogenetic groups with the immunotherapy treatment outcomes of certain tumors. On the other side of the coin, recently it has been a resurgence in interest on the potential use of bacteria to cure cancer. These kinds of treatments were used in the late nineteenth and early twentieth centuries as the first line of defense against cancer in some hospitals but later displaced by other types of treatments such as radiotherapy. Currently, organisms such as Salmonella typhimurium and Clostridium spp. have been used for targeted strategies as potential vectors to treat cancer. In this review, we briefly summarize our current knowledge of the role of the oral microbiome, focusing on its bacterial fraction, in cancer in general and in OSCC more precisely, and a brief description of the potential use of bacteria to target tumors.

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“…Several studies established that Fusobacterium nucleatum plays a major role in colorectal carcinogenesis via Fap2 mediated binding to tumor-overexpressed Gal-GalNAc-binding lectin [38][39][40]. Therefore, F. nucleatum was deemed useful as a microbial biomarker for colorectal cancer detection [41]. Interestingly, we discovered that the phylogenetically similar Fusobacterium massiliense, which exhibited substantial sequence similarity with F. nucleatum, has a signi cant relative abundance among more nicotine dependent smokers.…”

Section: Discussionmentioning

confidence: 79%

Revealing oral microbiota composition and functionality associated with heavy cigarette smoking.

Bataineh

¹

,

Dash

²

,

Elkhazendar

³

et al. 2020

Preprint

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Background: Heavy tobacco smoking, a hallmark feature of lung cancer, is drastically predominant in Middle Eastern populations. The precise links between nicotine dependence and the functional contribution of the oral microbiota remain unknown in these populations.Methods: We evaluated the composition and functional capabilities of oral microbiota with relation to cigarette smoking in 105 adults through shotgun metagenomics using buccal swabs. Results: The oral microbiota composition in our study subjects was dominated by the phyla Firmicutes, Proteobacteria, Actinobacteria, and Bacteroidetes, in addition to the genera Prevotella and Veillonella, similar to previously described westernized cohorts. Furthermore, the smoker's oral microbiota represented a significant abundance of Veillonella dispar, Leptotrichia spp., and Prevotella pleuritidis when compared to non-smokers. Within the smoking groups, differential relative abundance testing unveiled relative abundance of Streptobacillus hongkongensis, Fusobacterium massiliense, Prevotella bivia in high nicotine dependent compared to low nicotine dependent profiles based on Fagerström Test for Nicotine Dependence. Functional profiling showed marked differences between smokers and non-smokers. Smokers exhibited an enrichment of Tricarballylate utilization and Lactate racemization when compared to the non-smokers. According to their nicotine dependence, enrichment of Xanthosine utilization, p-Aminobenzoyl-Glutamate utilization, and multidrug efflux pump in Campylobacter jejuni biosynthesis modules were detected in the high nicotine dependent group. Conclusions: These compositional and functional differences may provide critical insight on how variations in the oral microbiota could predispose to respiratory illnesses and smoke cessation relapse in cigarette smokers. In particular, the observed enrichment of Fusobacterium and Prevotella in the oral microbiota possibly suggests an intriguing linkage to gut and lung cancers.

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“…Several studies established that Fusobacterium nucleatum plays a major role in colorectal carcinogenesis via Fap2 mediated binding to tumor-overexpressed Gal-GalNAc-binding lectin [40][41][42]. Therefore, F. nucleatum was deemed useful as a microbial biomarker for colorectal cancer detection [43]. Interestingly, we discovered that the phylogenetically similar Fusobacterium massiliense, which exhibited substantial sequence similarity with F. nucleatum, has a signi cant relative abundance among more nicotine dependent smokers.…”

Section: Discussionmentioning

confidence: 79%

Revealing oral microbiota composition and functionality associated with heavy cigarette smoking.

Bataineh

¹

,

Dash

²

,

Elkhazendar

³

et al. 2020

Preprint

1

0

View full text Add to dashboard Cite

Background: Heavy tobacco smoking, a hallmark feature of lung cancer, is drastically predominant in Middle Eastern populations. The precise links between nicotine dependence and the functional contribution of the oral microbiota remain unknown in these populations.Methods: We evaluated the composition and functional capabilities of oral microbiota with relation to cigarette smoking in 105 adults through shotgun metagenomics using buccal swabs. Results: The oral microbiota composition in our study subjects was dominated by the phyla Firmicutes, Proteobacteria, Actinobacteria, and Bacteroidetes, in addition to the genera Prevotella and Veillonella, similar to previously described westernized cohorts. Furthermore, the smoker's oral microbiota represented a significant abundance of Veillonella dispar, Leptotrichia spp., and Prevotella pleuritidis when compared to non-smokers. Within the smoking groups, differential relative abundance testing unveiled relative abundance of Streptobacillus hongkongensis, Fusobacterium massiliense, Prevotella bivia in high nicotine dependent compared to low nicotine dependent profiles based on Fagerström Test for Nicotine Dependence. Functional profiling showed marked differences between smokers and non-smokers. Smokers exhibited an enrichment of Tricarballylate utilization and Lactate racemization when compared to the non-smokers. According to their nicotine dependence, enrichment of Xanthosine utilization, p-Aminobenzoyl-Glutamate utilization, and multidrug efflux pump in Campylobacter jejuni biosynthesis modules were detected in the high nicotine dependent group. Conclusions: These compositional and functional differences may provide critical insight on how variations in the oral microbiota could predispose to respiratory illnesses and smoke cessation relapse in cigarette smokers. In particular, the observed enrichment of Fusobacterium and Prevotella in the oral microbiota possibly suggests an intriguing linkage to gut and lung cancers.

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Diagnostic Performance of Intestinal Fusobacterium nucleatum in Colorectal Cancer

Cited by 26 publications

References 37 publications

The Oral Microbiome and Cancer

The Oral Microbiome and Cancer

Revealing oral microbiota composition and functionality associated with heavy cigarette smoking.

Revealing oral microbiota composition and functionality associated with heavy cigarette smoking.

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