Diagnostic performance of IOTA simple rules for adnexal masses classification: a comparison between two centers with different ovarian cancer prevalence

Gauna, B. Ruiz de; Rodríguez, David Avelar; Olartecoechea, Begoña; Aubá, M.; Jurado, M.; Roig, María Dolores Gómez; Alcázar, Juan Luis

doi:10.1016/j.ejogrb.2015.05.024

Cited by 21 publications

(11 citation statements)

References 17 publications

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“…In our study, the accuracy of SR ± SA was in line with previous studies, with an observed sensitivity (considering the entire study sample) of 82% (84–100% in previous studies), specificity of 92% (74–96% in previous studies), PPV of 74% (67–88% in previous studies) and NPV of 95% (93–97% in previous studies) (Table ).…”

Section: Discussionsupporting

confidence: 91%

“…As the SR ± SA triage strategy was introduced into the study hospitals for the purpose of the study, we assessed our performance with this strategy by comparing our data with those of previous studies (Table ). In our study, SR were conclusive in 349/391 patients (i.e.…”

Section: Discussionmentioning

confidence: 92%

“…malignant vs benign). As secondary analyses, we estimated the cost‐effectiveness of the four strategies in a real, unselected population of women and verified the diagnostic accuracy of SR ± SA at the study hospitals, comparing this performance with data from previous studies. Based on our findings, we aim to disseminate the most effective strategy to other institutions across the Piemonte Region in Italy and optimize the diagnostic pathway of patients and the financial commitment of the national healthcare system.…”

Section: Introductionmentioning

confidence: 95%

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Diagnostic accuracy and cost‐effectiveness of different strategies to triage women with adnexal masses: a prospective study

Piovano

Cavallero

Fuso

et al. 2017

Ultrasound in Obstet & Gyne

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 95%

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Diagnostic accuracy and cost‐effectiveness of different strategies to triage women with adnexal masses: a prospective study

Piovano

Cavallero

Fuso

et al. 2017

Ultrasound in Obstet & Gyne

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“…Our results might not necessarily be applicable to less experienced operators. However, published studies have shown that the IOTA SRs and ADNEX retain their performance in the hands of less experienced examiners [27,28,35,36,37,38,39,40,41]. This is likely to be true also for the SRR model, because the same ultrasound variables are used in the original SRs are used to calculate the risks of the SRR model.…”

Section: Discussionmentioning

confidence: 99%

Validation of the Performance of International Ovarian Tumor Analysis (IOTA) Methods in the Diagnosis of Early Stage Ovarian Cancer in a Non-Screening Population

et al. 2017

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Background: The aim of this study was to assess and compare the performance of different ultrasound-based International Ovarian Tumor Analysis (IOTA) strategies and subjective assessment for the diagnosis of early stage ovarian malignancy. Methods: This is a secondary analysis of a prospective multicenter cross-sectional diagnostic accuracy study that included 1653 patients recruited at 18 centers from 2009 to 2012. All patients underwent standardized transvaginal ultrasonography by experienced ultrasound investigators. We assessed test performance of the IOTA Simple Rules (SRs), Simple Rules Risk (SRR), the Assessment of Different NEoplasias in the adneXa (ADNEX) model and subjective assessment to discriminate between stage I-II ovarian cancer and benign disease. Reference standard was histology after surgery. Results: 230 (13.9%) patients proved to have stage I–II primary invasive ovarian malignancy, and 1423 (86.1%) had benign disease. Sensitivity and specificity with respect to malignancy (95% confidence intervals) of the original SRs (classifying all inconclusive cases as malignant) were 94.3% (90.6% to 96.7%) and 73.4% (71.0% to 75.6%). Subjective assessment had a sensitivity and specificity of 90.0% (85.4% to 93.2%) and 86.7% (84.9% to 88.4%), respectively. The areas under the receiver operator characteristic curves of SRR and ADNEX were 0.917 (0.902 to 0.933) and 0.905 (0.920 to 0.934), respectively. At a 1% risk cut-off, sensitivity and specificity for SRR were 100% (98.4% to 100%) and 38.0% (35.5% to 40.6%), and for ADNEX were 100% (98.4% to 100%) and 19.4% (17.4% to 21.5%). At a 30% risk cut-off, sensitivity and specificity for SRR were 88.3% (83.5% to 91.8%) and 81.1% (79% to 83%), and for ADNEX were 84.5% (80.5% to 89.6%) and 84.5% (82.6% to 86.3%). Conclusion: This study shows that all three IOTA strategies have good ability to discriminate between stage I-II ovarian malignancy and benign disease.

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“…They have now been broadly accepted and are widely used in clinical practice. [38][39][40][41][42][43][44][45][46] More recently, a logistic regression model based on the ultrasound features of the original Simple Rules was developed-the Simple Rules risk model. This model is able to provide an individual estimated risk of malignancy for any type of lesion.…”

Section: Iota Methodsmentioning

confidence: 99%

ESGO/ISUOG/IOTA/ESGE Consensus Statement on pre-operative diagnosis of ovarian tumors

Timmerman

Planchamp

Bourne

et al. 2021

Int J Gynecol Cancer

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The European Society of Gynaecological Oncology (ESGO), the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG), the International Ovarian Tumour Analysis (IOTA) group, and the European Society for Gynaecological Endoscopy (ESGE) jointly developed clinically relevant and evidence-based statements on the pre-operative diagnosis of ovarian tumors, including imaging techniques, biomarkers, and prediction models. ESGO/ISUOG/IOTA/ESGE nominated a multidisciplinary international group, including expert practising clinicians and researchers who have demonstrated leadership and expertise in the pre-operative diagnosis of ovarian tumors and management of patients with ovarian cancer (19 experts across Europe). A patient representative was also included in the group. To ensure that the statements were evidence-based, the current literature was reviewed and critically appraised. Preliminary statements were drafted based on the review of the relevant literature. During a conference call, the whole group discussed each preliminary statement and a first round of voting was carried out. Statements were removed when a consensus among group members was not obtained. The voters had the opportunity to provide comments/suggestions with their votes. The statements were then revised accordingly. Another round of voting was carried out according to the same rules to allow the whole group to evaluate the revised version of the statements. The group achieved consensus on 18 statements. This Consensus Statement presents these ESGO/ISUOG/IOTA/ESGE statements on the pre-operative diagnosis of ovarian tumors and the assessment of carcinomatosis, together with a summary of the evidence supporting each statement.

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Diagnostic performance of IOTA simple rules for adnexal masses classification: a comparison between two centers with different ovarian cancer prevalence

Cited by 21 publications

References 17 publications

Diagnostic accuracy and cost‐effectiveness of different strategies to triage women with adnexal masses: a prospective study

Diagnostic accuracy and cost‐effectiveness of different strategies to triage women with adnexal masses: a prospective study

Validation of the Performance of International Ovarian Tumor Analysis (IOTA) Methods in the Diagnosis of Early Stage Ovarian Cancer in a Non-Screening Population

ESGO/ISUOG/IOTA/ESGE Consensus Statement on pre-operative diagnosis of ovarian tumors

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