Diagnostic performance of isolated-check visual evoked potential versus retinal ganglion cell-inner plexiform layer analysis in early primary open-angle glaucoma

Chen, Xiangwu; Zhao, YingXi

doi:10.1186/s12886-017-0472-9

Cited by 18 publications

(14 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chen and Zhao also reported that the sensitivity of the icVEP in 15% positive contrast and 10 Hz temporal modulation was 80% and the specificity was 90% for diagnosing early POAG, but they defined GON as a cup-disc ratio ≥0.6 or vertical cup/disc diameter ratio asymmetry ≥0.2 and did not analyze the MD of the visual field test. [ 20 ] With different GON criterion, the sensitivity of the icVEP was 62.5% and the specificity was 92.3% for diagnosing early POAG in the current study, which might be due to the smaller MD of the visual field test.…”

Section: Discussionmentioning

confidence: 67%

“…Recent studies demonstrated that the accuracy of the icVEP for diagnosing glaucoma is high, ranging from 91% to 100%,[ 8 17 ] especially for early glaucoma in Asians with a sensitivity of 53.1–82.2% and a specificity of 57.6–90%. [ 19 20 21 ] Age and sex differences in samples between patients and healthy controls existed in these studies, however, and none of these studies evaluated the diagnostic value of the icVEP in only patients diagnosed with early stage of OAG, comprising both primary OAG (POAG) and normal-tension glaucoma (NTG). Therefore, we performed this cross-sectional study in China to further evaluate the potential diagnostic value of the icVEP in patients with early-stage POAG and NTG.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Applications of Isolated-Check Visual Evoked Potential in Early Stage of Open-Angle Glaucoma Patients

Fan

Xia³

et al. 2018

Chinese Medical Journal

View full text Add to dashboard Cite

Background:Standard automated perimetry does not sufficiently detect early open-angle glaucoma (OAG) in the clinic. New visual function tests for early glaucoma damage are therefore needed. The present study evaluated whether an isolated-check visual evoked potential (icVEP) could be used to detect visual function abnormalities in early-stage OAG and to explore potential related factors.Methods:This was a cross-sectional study. Thirty-seven OAG patients with early-stage visual field loss (mean deviation ≥ −6.00 dB) detected by the Humphrey Field Analyzer (30-2 SITA program) and 26 controls were included in this study. Optical coherence tomography (OCT) was used to detect retinal nerve fiber layer (RNFL) defects. The icVEP preferentially evaluates the magnocellular-ON pathway. VEPs were recorded and signal-to-noise ratios (SNRs) were derived based on multivariate analysis. Eyes that yielded an SNR ≤1 were considered abnormal. Receiver operating characteristic (ROC) curve analysis was used to estimate the accuracy of group classification. Correlations between SNRs and related factors were analyzed.Results:Based on an SNR criterion of 1, the icVEP had a sensitivity of 62.2% and a specificity of 92.3% for diagnosing early-stage OAG with 74.6% classification accuracy. The ROC curve analysis, however, suggested that an SNR criterion of 0.93 would produce the highest classification accuracy (77.3%). Both RNFL thinning in the temporal superior quadrant on OCT and number of abnormal test points in the central 11° visual field (pattern deviation, P < 0.5%) significantly correlated with the SNR (P < 0.05).Conclusions:The icVEP detected visual function abnormalities in approximately 3/5 of eyes with early-stage OAG with greater than 90% specificity. SNR correlated with both a decrease in RNFL thickness and severity of central visual field loss.

show abstract

Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Applications of Isolated-Check Visual Evoked Potential in Early Stage of Open-Angle Glaucoma Patients

Fan

Xia³

et al. 2018

Chinese Medical Journal

View full text Add to dashboard Cite

show abstract

“…The electrodes impedance was maintained below 5 kOhm. Flash-PEV stimulation is less sensitive than the pattern examination to the visual system dysfunction, and is mainly reserved for young, non-cooperating patients with media opacities or large refractive errors that cannot collaborate for pattern-PEV [ 11 ]. After the flash stimulation, the amplitude and latency of the resulting P2 wave were also analyzed.…”

Section: Methodsmentioning

confidence: 99%

“…The VEP and the OCT are powerful methods for glaucoma diagnosis. The sensitivity and specificity of these methods are similar in detecting early damage [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The neuroprotective role of citicoline treatment in glaucoma – 6 months results of a prospective therapeutic trial

Chițu¹,

Voinea²,

Istrate³

et al. 2019

rjo

View full text Add to dashboard Cite

Objectives. Neuroprotective treatment, including citicoline, is a new perspective in glaucoma management, having the role of progression delay. The purpose of the present study was to observe the evolution of the different parameters in patients with glaucoma treated with citicoline.Methods. 22 patients with GPUD were enrolled in the study, and they received oral citicoline in addition to the ocular hypotensive therapy. Investigations were performed at the beginning of the current study, then at 3 months and 6 months, and included, besides full ophthalmologic checkup and IOP determination, optic nerve and RGCs OCT, and visual evoked potentials, pattern and flash. The data we obtained were statistically analyzed with the SPSS (Microsoft) program. Results. The outcomes of the study following VEP wave analysis indicated variations in P100 wave amplitude, but after 6 months period, an increase was found. Also, the P2 wave amplitude recorded statistically insignificant variations. The increase in P2 latency at 6 months was noted as statistically significant. Negative correlations were also met between the thickness of the RGC layer and the P100 latency, but also between the amplitude and the latency of this wave. At 6 months, a positive correlation between the RGC layer and the P100 amplitude was observed. The RNFL thickness at the optical disc had higher values at the 6 months visit, it was statistically significant, and a slight increase in the thickness of the RGC layer between successive visits was noted. These might be an examination artifact because clinically they are not possible. The RNFL thickness showed a positive correlation with the amplitude of P100 and P2 waves.Conclusions. The study of the parameters and their correlations demonstrated that citicoline had positive effects in glaucoma on certain aspects, data confirmed by literature.

show abstract

“…Clinical treatment mainly aims to reduce intraocular pressure and maintain the normal range of intraocular pressure, main treatments include laser, drugs, surgery and other methods ( 1 ). Basic study confirmed that ( 2 ) retinal ganglion cell (RGC) apoptosis and optic nerve axon degeneration caused by ischemia, oxidative stress and inflammatory response are important causes of the occurrence and development of glaucoma. Malondialdehyde (MDA), nitric oxide (NO) and superoxide dismutase (SOD) are the most commonly used biochemical markers for the evaluation of glaucoma animal model and glaucoma patients with oxidative stress disorder.…”

Section: Introductionmentioning

confidence: 95%

Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction

2017

View full text Add to dashboard Cite

The treatment of glaucomatous optic nervedamage using ginsenoside Rg1 mediated by ultrasound targeted microbubbles destruction was evaluated. Thirty healthy New Zealand white rabbits were subjected to injection of 0.3% carbomer solution to establish glaucomatous optic nerve damage model. Rabbits were divided into 5 groups: control group, model group, model group + intravitreal injection of nerve growth factor (NGF) group, model group + intravitreal injection of ginsenoside Rg1 group (Rg1 group), model group + intravitreal injection of ginsenoside Rg1 + ultrasound microbubble group (ultrasound group), model group + ultrasound targeted microbubble destruction (ultrasound group). Intraocular pressures were compared at 1, 2 and 4 weeks after model establishment. Rabbits were sacrificed 4 weeks after model establishment to collect retinal tissue for H&E staining. Histological changes were observed and the retinal thickness was measured. Contents of malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) were measured by ELISA. Intraocular pressure was significantly higher in model group than in control group at 1 week (P<0.05). Intraocular pressure was significantly lower in the ultrasound group than in NGF group and Rg1 group at all time-points (P<0.05). The number of ganglion cells in model group was decreased significantly. Number of nuclear layer cells was significantly reduced. Thickest retina was found in control group and model group was the thinnest (P<0.05). Contents of MDA and NO in model group were significantly higher than those in NCF group and Rg1 group. SOD content in control group was higher than that in ultrasound group and model group (P<0.05). In conclusion, treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction can reduce the level of oxidative stress, relieve intraocular pressure and reduce ganglion cell damage.

show abstract

Diagnostic performance of isolated-check visual evoked potential versus retinal ganglion cell-inner plexiform layer analysis in early primary open-angle glaucoma

Cited by 18 publications

References 19 publications

Applications of Isolated-Check Visual Evoked Potential in Early Stage of Open-Angle Glaucoma Patients

Applications of Isolated-Check Visual Evoked Potential in Early Stage of Open-Angle Glaucoma Patients

The neuroprotective role of citicoline treatment in glaucoma – 6 months results of a prospective therapeutic trial

Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction

Contact Info

Product

Resources

About