Diagnostic Performance of MRI in the Detection of Renal Lipid-Poor                    Angiomyolipomas: A Systematic Review and Meta-Analysis

Wilson, Mitchell P; Patel, Deelan; Murad, M. Hassan; McInnes, Matthew D. F.; Katlariwala, Prayash; Low, Gavin

doi:10.1148/radiol.2020192070

Cited by 18 publications

(13 citation statements)

References 38 publications

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“…The DWI signal, which provides functional tissue information, has potential as a biomarker for tumour characteristics [8,9]. According to a meta-analysis reported by Wilson et al, the sensitivity, specificity, and AUC values of DWI for differentiating fpAML from ccRCC were 0.89, 0.87, 0.94, respectively [4]. In this study, a diagnostic model derived from texture ADC map features improved the diagnostic performance of conventional ADC analysis.…”

Section: Discussionmentioning

confidence: 55%

“…A particular challenge in this setting is the preoperative imaging diagnosis of fat-poor (fp) angiomyolipoma (AML), defined as AML with no visible fat on imaging because of limited fat content in the tumour, which accounts for 5% of AMLs [1][2][3]. A recent meta-analysis of 23 studies by Wilson et al revealed that preoperative magnetic resonance imaging (MRI) showed promising accuracy for discriminating between fpAMLs and clear-cell renal cell carcinomas (ccRCCs) (area under the receiver operating characteristic curve [AUC], 0.96) [4]. Their results indicated the potential to replace biopsy in such situations.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic value of texture analysis of apparent diffusion coefficient maps for differentiating fat-poor angiomyolipoma from non-clear-cell renal cell carcinoma

Arita

Yoshida

Kwee

et al. 2021

European Journal of Radiology

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Diagnostic value of texture analysis of apparent diffusion coefficient maps for differentiating fat-poor angiomyolipoma from non-clear-cell renal cell carcinoma

Arita

Yoshida

Kwee

et al. 2021

European Journal of Radiology

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“…There is limited literature on the usefulness of computed tomography and magnetic resonance imaging in differentiating AML from other renal tumors, but recent studies show promising results for detecting lipid-poor AMLs and may play a role when contemplating active surveillance versus biopsy. [ 27 28 29 ] A large retrospective study on small AMLs[ 30 ] suggested that concerning features on ultrasound include irregular tumor borders, presence of calcification, extension beyond the renal capsule, and a size >4 cm. The slow annual growth rate of about 0.27 mm prompted these authors to suggest that subcentimeter asymptomatic AMLs, with no concerning ultrasound features, do not need further characterization or follow-up.…”

Section: Discussionmentioning

confidence: 99%

Adult renal angiomyolipomas: A retrospective analysis of the histological subtypes and their clinicoradiological correlates

et al. 2022

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Background: Renal angiomyolipomas (AMLs) are rare, benign mesenchymal tumors of the kidney. Asian data on the prevalence of the subtypes of AMLs and their association with tuberous sclerosis are sparse prompting us to evaluate the clinicopathological characteristics of these tumors. Materials and Methods: We included cases diagnosed from 2001 to 2021 extracting demographic details, clinical presentation, syndromic association with tuberous sclerosis, and preoperative clinicoradiological features from the electronic medical records. Results: Ninety-five cases of adult renal AML were diagnosed among 2402 renal tumors, a prevalence of 3.95%. Forty tumors (42%) were detected incidentally; two patients had life-threatening retroperitoneal hemorrhage. Tuberous sclerosis complex (TSC) was associated with ten cases (10.5%). These patients were a decade younger than those in the non-TSC group (P = 0.008) and had bilateral, multiple, and larger tumors (P = 0.0009, 0.001, and 0.047, respectively). Microscopically, classic and epithelioid subtypes were seen in 87 (91.6%) and 8 cases (8.4%), respectively. Hemorrhage was more common in the epithelioid subtype (P = 0.13). HMB-45, melan-A, and smooth muscle actin immunohistochemistry were useful in cases which lacked the prototypical classic histology and for confirming a diagnosis of epithelioid AML. Conclusions: The prevalence of renal AML in our series was four times higher, and the mean age at diagnosis was a decade earlier than that reported in Western literature but similar to data from two Asian countries. Similar studies from other countries will help ascertain if these differences in prevalence can be attributed to ethnic differences.

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“…38 6d: "All studies were at high risk of bias for the index test domain because no reported thresholds were prespecified." 39…”

Section: Registration: Cd010502 (Cochrane)mentioning

confidence: 99%

Preferred reporting items for journal and conference abstracts of systematic reviews and meta-analyses of diagnostic test accuracy studies (PRISMA-DTA for Abstracts): checklist, explanation, and elaboration

Cohen

Deeks

Hooft

et al. 2021

BMJ

Self Cite

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For many users of the biomedical literature, abstracts may be the only source of information about a study. Hence, abstracts should allow readers to evaluate the objectives, key design features, and main results of the study. Several evaluations have shown deficiencies in the reporting of journal and conference abstracts across study designs and research fields, including systematic reviews of diagnostic test accuracy studies. Incomplete reporting compromises the value of research to key stakeholders. The authors of this article have developed a 12 item checklist of preferred reporting items for journal and conference abstracts of systematic reviews and meta-analyses of diagnostic test accuracy studies (PRISMA-DTA for Abstracts). This article presents the checklist, examples of complete reporting, and explanations for each item of PRISMA-DTA for Abstracts.

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Diagnostic Performance of MRI in the Detection of Renal Lipid-Poor Angiomyolipomas: A Systematic Review and Meta-Analysis

Cited by 18 publications

References 38 publications

Diagnostic value of texture analysis of apparent diffusion coefficient maps for differentiating fat-poor angiomyolipoma from non-clear-cell renal cell carcinoma

Diagnostic value of texture analysis of apparent diffusion coefficient maps for differentiating fat-poor angiomyolipoma from non-clear-cell renal cell carcinoma

Adult renal angiomyolipomas: A retrospective analysis of the histological subtypes and their clinicoradiological correlates

Preferred reporting items for journal and conference abstracts of systematic reviews and meta-analyses of diagnostic test accuracy studies (PRISMA-DTA for Abstracts): checklist, explanation, and elaboration

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