Diagnostic Performance of On-Site Automatic Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve

Abstract

Author's summary With recent advancements, fractional flow reserve (FFR) can be computed from coronary computed tomography angiography (CCTA). This study validated the diagnostic performance of the on-site automatic CCTA-derived FFR (CT-FFR) using a commercially available workstation to define ischemia-causing coronary artery disease (CAD). This on-site CT-FFR showed a diagnostic accuracy of 80.6%, a sensitivity of 88.1%, and a specificity of 75.6% to predict FFR ≤0.80. In addition, the diagnostic performance and discriminant ability of CT-FFR to predict FFR ≤0.80 were better than those of stenosis severity from CCTA. The current CT-FFR solution can provide useful information on the hemodynamic significance of CAD.

While Awaiting CT-FFR Era: A Novel Approach to Assess Functionally Significant Stenosis With On-Site CT-FFR

“…In this issue of the Journal, Hwang et al 7) validated a newly developed on-site CT-FFR compared with invasive FFR in patients with coronary artery disease who underwent CCTA and invasive coronary angiography. The research aims to address the limitations of traditional CT-FFR computation methods by introducing a novel, simpler on-site approach.…”