Diagnostic Performance of Total Platelet Count, Platelet-to-Lymphocyte Ratio, and Lymphocyte-to-Monocyte Ratio for Overall and Complicated Pediatric Acute Appendicitis: A Systematic Review and Meta-Analysis

Montero, Javier Arredondo; Riveros, Blanca Paola Pérez; Martín‐Calvo, Nerea

doi:10.1089/sur.2023.013

Cited by 10 publications

(4 citation statements)

References 24 publications

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“…Recently, laboratory markers in differentiation between uncomplicated and complicated appendicitis have been explored. Specific to pediatric appendicitis, systemic reviews and meta-analyses performed have suggested the platelet-to-lymphocyte ratio [ 16 ], higher serum total bilirubin level [ 17 ], and elevated serum interleukin-6 [ 18 ] may be of value in early discrimination of complicated appendicitis. Significantly lower levels of sodium were also found in children with complicated appendicitis [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Predicting Complicated Appendicitis in Children

Lin,

Lee,

Chen

et al. 2024

Diagnostics

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Background: Acute appendicitis is a common abdominal emergency observed in emergency departments (ED). Distinguishing between uncomplicated and complicated appendicitis is important in determining a treatment strategy. Serum soluble vascular cell adhesion molecule-1 (VCAM-1) is an inflammatory biomarker. We aimed to determine the role of VCAM-1 in predicting complicated appendicitis in children. Methods: Pediatric patients with suspected appendicitis admitted to the ED were enrolled in this prospective study. Pre-surgical serum VCAM-1 was tested in children with acute appendicitis within 72 h of symptoms (from day 1 to day 3). Serum VCAM-1 levels were further analyzed and compared between patients with and without complicated appendicitis. Results: Among the 226 pediatric appendicitis patients, 70 had uncomplicated appendicitis, 138 had complicated appendicitis, and 18 had normal appendices. The mean serum VCAM-1 levels in patients with perforated appendicitis were higher than in those with simple appendicitis (p < 0.001). On day 1 to day 3, the mean VCAM-1 levels in patients with complicated appendicitis were all significantly higher than in those with uncomplicated appendicitis (all p < 0.001). Conclusion: Serum VCAM-1 levels may be helpful in differentiating uncomplicated and complicated appendicitis in children and could predict appendiceal perforation.

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Section: Introductionmentioning

confidence: 99%

The Role of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Predicting Complicated Appendicitis in Children

Lin,

Lee,

Chen

et al. 2024

Diagnostics

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“…When these biomarkers and imaging techniques are used together, they provide the advantage of rapid diagnosis. Therefore, new and speci c biomarkers are needed to capture complications [3,4].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Systemic Inflammation Index and Systemic Inflammatory Response Index on Predicting Acute Appendicitis Complications in Children Under Five Years Old

Özçelik,

Cesur,

Parlakgümüş

2024

Preprint

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Objective The aim of our study is to determine the value of SII (Systemic Inflammation Index) and SIRI (Systemic Inflammatory Response Index), biomarkers whose usage has increased in recent years, in predicting acute appendicitis complications in children under five years old. Specifically, due to the difficulty in diagnosing and managing acute appendicitis in children under five, we aimed to investigate the usability of these indices in determining the risk of complications of acute appendicitis and in developing clinical management strategies. Materials and Methods The study was conducted with 178 patients who met the inclusion and exclusion criteria. The laboratory values, surgical notes, and pathology results of the cases were recorded from patient files and the automation system, and statistical analyses were performed. Results The laboratory values of Platelet, Monocyte, SIRI, CRP, and Procalcitonin in the complicated appendicitis group were higher compared to those in the simple appendicitis group (p = 0.046; p = 0.035; p = 0.042; p = 0.001; p = 0.001, respectively). According to the results of the ROC Curve test, the SIRI score had an AUC of 59%, sensitivity of 67.37%, and specificity of 54.43%, while the CRP value had the best diagnostic test performance in predicting complicated appendicitis with an AUC value of 64.3%, sensitivity of 63.54%, and specificity of 61.25%. Conclusion In our study evaluating SII and SIRI, we found that especially SIRI, along with CRP and procalcitonin, was higher in the complicated group. However, the predictive power of CRP for complications was greater than these indices. We believe that randomized controlled and larger studies should be conducted to evaluate the use of these new-generation markers in acute appendicitis.

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“…Many efforts have been made in the last decades to optimize the diagnostic performance of AA. This has led to the appearance of promising biomarkers, such as Interleukin-6 [4] and novel blood count ratios (i.e platelet-to-lymphocyte ratio, or systemic-immune in ammation index) [5,6] that improve parameters classically used in isolation, such as leukocytosis and neutrophilia. The same has happened with the appearance of new multivariate indexes that have improved the diagnostic performance of the classic Alvarado score [7,8].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of urinary 5-Hydroxyindoleacetic Acid in acute appendicitis: a systematic review and diagnostic test accuracy meta-analysis

Arredondo Montero,

Bueso Asfura,

Pérez Riveros

et al. 2023

Int J Colorectal Dis

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BackgroundThis study aimed to analyze the diagnostic performance of urinary 5-Hydroxyindoleacetic Acid (5-HIAA) in acute appendicitis (AA). MethodsWe conducted a systematic review of the literature in the main databases of medical bibliography. Two independent reviewers selected the articles and extracted relevant data. Methodological quality was assessed using the QUADAS2 index. A synthesis of the results, standardization of the metrics, and a random-effect meta-analysis were performed. Additionally, a diagnostic test accuracy meta-analysis (DTA) was performed. ResultsTwelve studies with data from 1467 participants (724 patients with a con rmed diagnosis of AA and 743 controls) were included in this review. The randomeffect meta-analysis of urinary 5-HIAA (AA vs controls) included 7 articles (352 AA and 258 controls) and resulted in a signi cant mean difference [95% CI] of 23.30 [15.82-30.77] µmol/L (p < 0.001). The DTA meta-analysis of urinary 5-HIAA included 8 articles and resulted in a pooled sensitivity [95% CI] of 68.6[44.1-85.9]% and a pooled speci city [95% CI] of 82 [54.7-94.5]%. ConclusionsAlthough the evidence is heterogeneous and limited, urinary 5-HIAA emerges as a potential non-invasive diagnostic tool for AA. Urinary 5-HIAA does not seem to be a useful biomarker to distinguish between NCAA and CAA. Future prospective studies with a large sample size and a rigorous design are necessary to validate these ndings.

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Diagnostic Performance of Total Platelet Count, Platelet-to-Lymphocyte Ratio, and Lymphocyte-to-Monocyte Ratio for Overall and Complicated Pediatric Acute Appendicitis: A Systematic Review and Meta-Analysis

Cited by 10 publications

References 24 publications

The Role of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Predicting Complicated Appendicitis in Children

The Role of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Predicting Complicated Appendicitis in Children

The Impact of Systemic Inflammation Index and Systemic Inflammatory Response Index on Predicting Acute Appendicitis Complications in Children Under Five Years Old

Diagnostic performance of urinary 5-Hydroxyindoleacetic Acid in acute appendicitis: a systematic review and diagnostic test accuracy meta-analysis

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