Diagnostic Pitfalls in Fine Needle Aspiration Cytology of Pleomorphic Lipoma

Thirumala, Seshadri; Desai, Mayuri; Kannan, V.

doi:10.1159/000328542

Cited by 16 publications

(16 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rarity of intramuscular pleomorphic lipomas and the atypical cellular features of the aspirate can cause difficulty in diagnosing this entity. [ 5 ] Even in our case, a malignant tumor was suspected because of the tumor location and the cytological picture. However, the classical histology of the excision specimen was reassuring.…”

Section: Discussionmentioning

confidence: 80%

“…While histology is well-documented in the literature, very few articles outline the cytological features of a pleomorphic lipoma. [ 5 6 7 8 ] The cytology shows a population of floret cells and pleomorphic cells admixed with adipocytes and spindle cells. [ 8 ] The floret cells show multiple enlarged hyperchromatic nuclei arranged in a circle or semicircle in the cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pleomorphic lipoma: A gentle giant of pathology

Sakhadeo

Mundhe

DeSouza

et al. 2015

J Cytol

View full text Add to dashboard Cite

Pleomorphic lipoma is a relatively rare adipocytic neoplasm, occurring predominantly in elderly males in the subcutaneous tissues of the neck or shoulder. To the best of our knowledge, only five cases have been reported in which the lesion was intramuscular. We hereby report a case of a 60-year-old female patient, presenting with an intramuscular, posterior shoulder mass. The aspirate showed a giant cell-rich lesion, admixed with short, plump-looking, spindly cells. There was no overt evidence of malignancy; however, the cell cytology was sufficiently atypical to warrant concern. Subsequent excision revealed a classical pleomorphic lipoma on histology with no evidence of malignancy. CD34 staining by immunohistochemistry further supported the diagnosis. Differential diagnosis and the cytological diagnostic pitfalls of pleomorphic lipomas have been discussed with a review of the literature.

show abstract

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Pleomorphic lipoma: A gentle giant of pathology

Sakhadeo

Mundhe

DeSouza

et al. 2015

J Cytol

View full text Add to dashboard Cite

show abstract

“…17 The distinction between pleomorphic lipoma and welldifferentiated liposarcoma (atypical lipomatous tumor) is important and may be difficult. [18][19][20] Both neoplasms may have floret cells and lipoblasts. However, the proportion of these cells is a clue to the diagnosis: liposarcomas have more lipoblasts, whereas these cells are much fewer in pleomorphic lipomas.…”

Section: Discussionmentioning

confidence: 99%

Fine needle aspiration of pleomorphic lipoma of the neck: Report of two cases

Chen

Tong

et al. 2009

Diagnostic Cytopathology

View full text Add to dashboard Cite

Pleomorphic lipoma is a rare lipocytic neoplasm that most commonly occurs in the head and neck region in middle-aged to elderly men. Clinically, it presents as a slow-growing, well-circumscribed subcutaneous mass. Histopathologically and cytogenetically, it has some features overlapping with other benign and malignant tumors, such as benign spindle cell lipoma, atypical lipomatous tumor, liposarcoma, and malignant fibrous histiocytoma. However, cure rates are high when pleomorphic lipoma is treated with complete surgical excision with clear margins. Therefore, an accurate preoperative diagnosis is very important for proper treatment. Due to the rarity of this tumor, few cases diagnosed by cytology have been reported in the English literature. Here, we report two cases of pleomorphic lipoma, the diagnoses of which were suggested on fine needle aspiration biopsies and subsequently confirmed by surgical excisions.

show abstract

“…[1][2][3][4][5][6][7][8] Five cases were considered suspicious/positive for malignancy for two main reasons: 1) the smears contained no adipose tissue or scarce or fragmented floret cells; and 2) the lumps were located at sites where malignancy is frequently diagnosed (supraclavicular area, neck, and breast). 2,3,5,6,8 Moreover, one of the cases in Skoog et al 1 was a well-differentiated liposarcoma that masqueraded as PL on cytologic grounds. Therefore, the presence of floret cells on smears is a source of false-positive and false-negative diagnoses in FNAC.…”

Section: Fine-needle Aspiration Of Pleomorphic Lipomamentioning

confidence: 99%

“…Therefore, the presence of floret cells on smears is a source of false-positive and false-negative diagnoses in FNAC. [1][2][3][4][5][6][7][8] Evidence to date suggests that a specific diagnosis of PL should only be rendered when there is excellent clinical (a circumscribed small mass in the subcutaneous tissue, usually in the neck and shoulder region) and cytologic (fragments of adipose tissue associated with wellpreserved floret cells, in a clean background) correlation.…”

Section: Fine-needle Aspiration Of Pleomorphic Lipomamentioning

confidence: 99%