Diagnostic potential of YKL-40 in bladder cancer

Yasar, Ozgur; Akçay, Tülay; Öbek, Can; Türegün, Fethi Ahmet

doi:10.1016/j.urolonc.2016.02.003

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…Elevated serum levels of YKL-40 have been reported in lung, bladder, ovarian, endometrial, renal, colorectal, breast cancers as well as in melanoma and other malignancies, and have been correlated with the stage of cancer and overall survival (10)(11)(12)(13)(14)(15)(16)(17)(18). Moreover, YKL-40 expression has been shown in the cells of many malignancies, such as melanoma, renal cell cancer, endometrial cancer, breast cancer, glial tumors, osteosarcoma, soft tissue sarcomas or squamous cell carcinomas of head, neck and esophagus (14,17,(19)(20)(21)(22)(23)(24).…”

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confidence: 99%

Chitinase-3-like Protein 1 (YKL-40) Expression in Squamous Cell Skin Cancer

et al. 2018

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Abstract. Background/Aim: YKL-40 plays a role in proliferation and differentiation of malignant cells. The aim of this study was to examine whether YKL-40 is expressed in cutaneous squamous cell carcinoma (SCC). Materials andChitinase-3-like protein 1 (YKL-40) is a glycoprotein discovered over 10 years ago (1). This protein belongs to the glycosyl hydrolase family 18, together with bacterial chitinases and several mammalian chitinase-like proteins (1). The biological function of YKL-40 is not fully understood; however, the studies conducted so far suggest its role in inflammation, cell differentiation, tissue remodeling and cancer growth. It is expressed and released by activated neutrophils, monocytes and macrophages (2). Various studies have reported its secretion by activated cells in inflammatory diseases, such as arthritic chondrocytes, arteritic vessels in giant cell arteritis, liver cells in viral hepatitis or atheromatous plaques and inflamed synovial membrane (3-5).The role of YKL-40 in cancer growth is not clearly understood; however, many reports imply that this protein plays a role in proliferation and differentiation of malignant cells. Its ability to activate many pathways, including the phosphoinositide-3-kinase pathway, suggests the possibility of inducing cancer cell proliferation and acting as an antiapoptotic and survival factor (6). Moreover, this protein is an adhesion and migration factor for vascular smooth muscle cells and promotes the migration of vascular endothelial cells (7). It is also suggested that YKL-40 may influence local synthesis of hyaluronan and act as an anticatabolic factor, preserving the extracellular tissue from destruction (8). These findings lead to the conclusion that YKL-40 stimulates tumor angiogenesis, promotes inflammation in tumor microenvironment and influences remodeling of the extracellular matrix, thus providing a better understanding of its role in cancer growth and metastasis (9).Elevated serum levels of YKL-40 have been reported in lung, bladder, ovarian, endometrial, renal, colorectal, breast cancers as well as in melanoma and other malignancies, and have been correlated with the stage of cancer and overall survival (10-18). Moreover, YKL-40 expression has been shown in the cells of many malignancies, such as melanoma, renal cell cancer, endometrial cancer, breast cancer, glial tumors, osteosarcoma, soft tissue sarcomas or squamous cell carcinomas of head, neck and esophagus (14,17,(19)(20)(21)(22)(23)(24). It has been even suggested that YKL-40 can serve as a new target for anticancer therapy (9,25). To the best of our knowledge there are no studies of YKL-40 expression in non-melanoma skin cancers. Therefore, the aim of this study was to examine whether YKL-40 is expressed in the tumor tissue of cutaneous squamous cell carcinoma (SCC). 4753This article is freely accessible online.

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confidence: 99%

Chitinase-3-like Protein 1 (YKL-40) Expression in Squamous Cell Skin Cancer

et al. 2018

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“…It was reported that not serum but urine YKL-40 level can be helpful in the diagnosis of bladder cancer in the assistance to BTA protein. Urine YKL-40 level was significantly higher in all invasive subgroups (T1, T2-T4, and T1-T4) compared to low stage (Ta) and can help determine treatment regimen in early invasive stages [42].…”

Section: Ykl-40 Is a Marker Of Late Stages Of Cancermentioning

confidence: 96%

Chitinase-Like Proteins as Promising Markers in Cancer Patients

et al. 2018

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In the present review we collected the main studies regarding the role of chitinase-like proteins (CLPs), belonging to the family of Glyco_18 domain-containing proteins, in different cancers. In humans, 3 chitinaselike proteins have been identified: YKL-40 (CHI3L1), YKL-39 (CHI3L2) and stabilin-1-interacting chitinase-like protein (SI-CLP). CLPs are produced by several types of cells and combine the properties of cytokines and growth factors. The high levels of CLPs were identified in the circulation of the patients with inflammatory diseases and various types of tumors. We highlighted the main known functions of CLPs in normal and pathological conditions, their contribution to metastasis development, angiogenesis, invasion and other processes in cancer, the correlation of the levels of CLPs with tumour progression. Our data also contribute to the understanding of question how CLP could be useful for cancer patient benefit.

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“…YKL-40 is a potent angiogenic factor and is thought to facilitate the formation of atherosclerotic plaques [8]. In addition, elevated YKL-40 levels have been found in cardiovascular disease, diabetes (T2DM), and several types of cancer [9, 10,11]. In this study we aimed to investigate the effect of an alpha-glucosidase inhibitor, acarbose, on coronary heart disease patients with impaired glucose tolerance (IGT) and the impact of acarbose on the serum YKL-40 concentrations of these patients.…”

Section: Introductionmentioning

confidence: 99%