Diagnostic Pregnancy Tests in Patients Treated with Tranquillizers

Shackcloth, P.

doi:10.1136/bmj.1.5486.517

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1969

1980

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Cited by 14 publications

(2 citation statements)

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“…Many pharmaceuticals, notably aspirin and tranquilizing agents such as chlorpromazine, thioridazine and promethazine, have often been cited as interfering substances (8,13,14). Their mechanisms of action have never been clearly defined, and in some instances these agents have even resulted in the production of false-negative reactions.…”

Section: Discussionmentioning

confidence: 99%

False‐Positive Hemagglutination Inhibition Tests for Pregnancy with Tubo‐ovarian Abscess

Jacobson

Rothe

1980

Intl J Gynecology & Obste

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Section: Discussionmentioning

confidence: 99%

False‐Positive Hemagglutination Inhibition Tests for Pregnancy with Tubo‐ovarian Abscess

Jacobson

Rothe

1980

Intl J Gynecology & Obste

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“…The effects of drugs on the various immunological pregnancy tests are not widely appreciated and most reports deal with the effects of psychotropic drugs (Marks & Shackcloth, 1966;Ravel, Riekers & Goldstein, 1969;Kerber, Inclan, Fowler, Davis & Fish, 1970) including promethazine (Phenergan®) (Tait, 1971) or oral contraceptives (Horwitz, Polesky, Odenbrett, Gronli, Horowitz, Diamond & Ward, 1971).…”

Section: Discussionmentioning

confidence: 99%

Effect of Methadone on Human Pregnancy Tests

Horwitz¹,

Maslansky²,

Waldinger³

et al. 1973

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A prospective study of four commercially available pregnancy tests was performed on 309 urine specimens specifically selected from patients in a methadone study group. The accuracy of the various tests, based on the total number of correct test results, was 99\m=.\7% for the Pregnosticon \s=r\ and UCG\s=r\tube tests, 96\m=.\4% for the Pregnosticon \ s=r\ slide test and 81\m=.\2% for the Gravindex\s=r\slide test. Analysis of the test data revealed that most of the false positive test results were recorded on specimens received from patients on 100 mg methadone, or more, per day. Semiquantitative thin-layer chromatography suggested that methadone metabolites could, at least in part, be responsible for the inhibition of latex particle agglutination and incorrect test results.

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