Diagnostic prospects and preclinical development of optical technologies using gold nanostructure contrast agents to boost endogenous tissue contrast

Dey, Priyanka; Blakey, Idriss; Stone, Nick

doi:10.1039/d0sc01926g

Cited by 22 publications

(22 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For real-time in vivo imaging, the Raman signal intensity needs to be significantly amplified, which can be achieved with the use of exogenous contrast agents that provide more intense spectra than the intrinsic Raman signal. [24][25][26][27][28][29] These contrast agents typically comprise plasmonic nanoparticle cores, Raman reporter molecules, dielectric shells, and ligands against specific targets, or other functional moieties, as shown in Fig. 1.…”

Section: Principles Of Raman Scattering Surface Enhanced Raman Scattering (Sers) and Surface Enhanced Resonance Raman Scattering (Serrs)mentioning

confidence: 99%

Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology

Kenry¹,

Nicolson²,

Clark³

et al. 2022

Nanotheranostics

View full text Add to dashboard Cite

In the last two decades, the application of surface enhanced Raman scattering (SERS) nanoparticles for preclinical cancer imaging has attracted increasing attention. Raman imaging with SERS nanoparticles offers unparalleled sensitivity, providing a platform for molecular targeting, and granting multiplexed and multimodal imaging capabilities. Recent progress has been facilitated not only by the optimization of the SERS contrast agents themselves, but also by the developments in Raman imaging approaches and instrumentation. In this article, we review the principles of Raman scattering and SERS, present advances in Raman instrumentation specific to cancer imaging, and discuss the biological means of ensuring selective in vivo uptake of SERS contrast agents for targeted, multiplexed, and multimodal imaging applications. We offer our perspective on areas that must be addressed in order to facilitate the clinical translation of SERS contrast agents for in vivo imaging in oncology.

show abstract

Section: Principles Of Raman Scattering Surface Enhanced Raman Scattering (Sers) and Surface Enhanced Resonance Raman Scattering (Serrs)mentioning

confidence: 99%

Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology

Kenry¹,

Nicolson²,

Clark³

et al. 2022

Nanotheranostics

View full text Add to dashboard Cite

show abstract

“…Gold nanoparticles have been studied for many years for effective PDT induction as well as drug carriers due to promising properties such as high surface area, facile surface modification through gold thiol chemistry, and biocompatibility. Furthermore, gold nanoparticles are being extensively studied for diagnostic applications because of their ability to tune optical scattering and absorption via physical features such as surface plasmon resonance effects [ 136 ]. Gold nanoparticles can be applied to PDT without the use of an organic PS.…”

Section: Nanotechnology For Enhanced Photodynamic Therapymentioning

confidence: 99%

Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors

Kim

Lee

2022

Biomedicines

View full text Add to dashboard Cite

The current treatment for malignant brain tumors includes surgical resection, radiotherapy, and chemotherapy. Nevertheless, the survival rate for patients with glioblastoma multiforme (GBM) with a high grade of malignancy is less than one year. From a clinical point of view, effective treatment of GBM is limited by several challenges. First, the anatomical complexity of the brain influences the extent of resection because a fine balance must be struck between maximal removal of malignant tissue and minimal surgical risk. Second, the central nervous system has a distinct microenvironment that is protected by the blood–brain barrier, restricting systemically delivered drugs from accessing the brain. Additionally, GBM is characterized by high intra-tumor and inter-tumor heterogeneity at cellular and histological levels. This peculiarity of GBM-constituent tissues induces different responses to therapeutic agents, leading to failure of targeted therapies. Unlike surgical resection and radiotherapy, photodynamic therapy (PDT) can treat micro-invasive areas while protecting sensitive brain regions. PDT involves photoactivation of photosensitizers (PSs) that are selectively incorporated into tumor cells. Photo-irradiation activates the PS by transfer of energy, resulting in production of reactive oxygen species to induce cell death. Clinical outcomes of PDT-treated GBM can be advanced in terms of nanomedicine. This review discusses clinical PDT applications of nanomedicine for the treatment of GBM.

show abstract

“…Yet again, the concluding remarks emphasised that most of the applications addressed in proof-of-principle studies are still far from clinical adoption and commercialisation. The need for the consistency of protocols is evident, and has been nicely put by Dey et al in their recent review article, as without standardisation they state that: "we are comparing apples to oranges and may be stuck with numbers that are not comparable from one research group to the other, thus leading nowhere" 138 .…”

Section: Cryopreservationmentioning

confidence: 99%

Clinical Spectroscopy: Lost in Translation?

Cameron¹,

Rinaldi

Rutherford

et al. 2021

Appl Spectrosc

View full text Add to dashboard Cite

This focal point article discusses the developments of biomedical Raman and infrared spectroscopy, and the recent strive towards being a recognised clinical tool for various applications. The promise of vibrational spectroscopy in the field of biomedical science, alongside the development of computational methods for spectral analysis, has driven a plethora of proof-of-concept studies which convey the potential of various spectroscopic approaches. Here we report a brief review of the literature published over the past few decades, with a focus on the current technical, clinical and economic barriers to translation, namely the limitations of many of these early studies, the lack of understanding of clinical pathways, health technology assessments, regulatory approval, clinical feasibility and funding applications. The field of biomedical vibrational spectroscopy must acknowledge and overcome these hurdles in order to achieve clinical efficacy. Current prospects have been overviewed with comment on the advised future direction of spectroscopic technologies, with the aspiration that many of these innovative approaches can ultimately reach the frontier of medical diagnostics and other clinical applications.

show abstract

Diagnostic prospects and preclinical development of optical technologies using gold nanostructure contrast agents to boost endogenous tissue contrast

Abstract: Numerous developments in optical biomedical imaging research utilizing gold nanostructures as contrast agents have advanced beyond basic research towards demonstrating potential as diagnostic tools; some of which are translating into...

Cited by 22 publications

References 107 publications

Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology

Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology

Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors

Clinical Spectroscopy: Lost in Translation?

Contact Info

Product

Resources

About