Diagnostic Quandary: Premature Ovarian Failure and Galactosemia Variants in Adolescent Girls with Delayed Puberty

Flint, Amanda C.; Hopwood, Nancy J.; Kasa-Vubu, Joséphine Z.

doi:10.1016/j.jpag.2008.07.020

Cited by 2 publications

References 15 publications

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Pubertal Delay and Hypogonadism

Rogol¹,

Fuqua²

2022

Oxford Textbook of Endocrinology and Diabetes 3e

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Delayed puberty occurs when no signs of pubertal maturation are seen by 14 years of age in boys or 13 years in girls. Although constitutional delay of growth and puberty is commonly seen and is often regarded as benign, there are many other causes of pubertal delay that ultimately result in permanent hypogonadism, and these must be differentiated from self-limited delays in maturation. Causes of hypogonadism include disorders affecting the gonads (primary hypogonadism) and abnormalities of pituitary or hypothalamic function (hypogonadotropic hypogonadism). Hypogonadotropic hypogonadism may be part of a more global set of pituitary deficiencies or may be the only endocrine axis affected. A rapidly growing array of genetic disorders accounts for isolated hypogonadotropic hypogonadism. Treatment of delayed puberty often consists of short-term administration of sex steroids to those with constitutional delay, while individuals with permanent hypogonadism require long-term testosterone or oestradiol replacement.

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Pubertal Delay and Hypogonadism

Rogol¹,

Fuqua²

2022

Oxford Textbook of Endocrinology and Diabetes 3e

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Delayed Puberty

Dye¹,

Nelson²,

Diaz-Thomas³

2018

Pediatr Ann

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Delayed puberty is defined as the absence of physical signs of puberty 2 to 2.5 standard deviations above the mean age and affects approximately 2% of adolescents. Causes of delayed puberty are broadly divided into two categories: hypergonadotropic hypogonadism and hypogonadotropic hypogonadism. One exception to this classification system is constitutional delay of growth and puberty, the most common cause of delayed puberty. For the general pediatrician, knowledge of the different causes and initial steps to evaluation is crucial when a patient with delayed puberty presents. [Pediatr Ann. 2018;47(1):e16-e22.].

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Diagnostic Quandary: Premature Ovarian Failure and Galactosemia Variants in Adolescent Girls with Delayed Puberty

Cited by 2 publications

References 15 publications

Pubertal Delay and Hypogonadism

Pubertal Delay and Hypogonadism

Delayed Puberty

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