Diagnostic role of collagen-III and matrix metalloproteinase-1 for early detection of hepatocellular carcinoma

Attallah, Abdelfattah M.; Albannan, Mohamed S.; El-Deen, M S; Kosari, Farid; Khedr, Fatma M.; Attallah, Kareem A.; Abdallah, Sanaa O.

doi:10.1080/09674845.2019.1708534

Cited by 9 publications

(12 citation statements)

References 32 publications

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“…The plasma levels of different types of collagens were found to be elevated in various malignancies, but for the moment, only a few molecules that belong to this family can be considered as possible biomarkers for early cancer detection. For example, a recent study suggested that the evaluation of COL3 and MMP-1 levels can be used for the early detection of hepatocellular carcinoma [ 57 ]. Similarly, in the case of breast cancer, the evaluation of the circulating level of COL11A1, COL10A1, and COMP (collagen oligomeric matrix protein) can discriminate between a malign and a benign disease [ 58 ].…”

Section: Collagen Family and Cancermentioning

confidence: 99%

Collagen Family as Promising Biomarkers and Therapeutic Targets in Cancer

Necula

Matei²,

Dragu³

et al. 2022

IJMS

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Despite advances in cancer detection and therapy, it has been estimated that the incidence of cancers will increase, while the mortality rate will continue to remain high, a fact explained by the large number of patients diagnosed in advanced stages when therapy is often useless. Therefore, it is necessary to invest knowledge and resources in the development of new non-invasive biomarkers for the early detection of cancer and new therapeutic targets for better health management. In this review, we provided an overview on the collagen family as promising biomarkers and on how they may be exploited as therapeutic targets in cancer. The collagen family tridimensional structure, organization, and functions are very complex, being in a tight relationship with the extracellular matrix, tumor, and immune microenvironment. Moreover, accumulating evidence underlines the role of collagens in promoting tumor growth and creating a permissive tumor microenvironment for metastatic dissemination. Knowledge of the molecular basis of these interactions may help in cancer diagnosis and prognosis, in overcoming chemoresistance, and in providing new targets for cancer therapies.

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Section: Collagen Family and Cancermentioning

confidence: 99%

Collagen Family as Promising Biomarkers and Therapeutic Targets in Cancer

Necula

Matei²,

Dragu³

et al. 2022

IJMS

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“…The increased expression of FN1 in both blood and tumors and its relative to poor survivallend additionally support the concept that MMP-produced cleaved collagens contribute to the metabolic activity and progression of PC tumors. 30,[43][44][45][46] In fact, collagen-III and MMP1 have been utilized for early detection of hepatocellular carcinoma, 47 emphasizing the strong possibility that FN1could be used as a diagnostic and prognostic indicator for PC. Futhermore, the use of ocriplasmin, a drug already approved by the FDA to treat diabetic retinopathy, 48 may be useful for treating PC, since it is an alpha-2 antiplasmin reducer and a truncated form of the natural human protein plasmin targeting FN1.…”

Section: Discussionmentioning

confidence: 99%

Unveiling Circulating Targets in Pancreatic Cancer: Insights from Proteogenomic Evidence and Clinical Cohorts

Feng,

Chen,

et al. 2024

Preprint

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Pancreatic cancer (PC), lacking biomarkers and effective therapeutics, remains highly lethal. Data regarding the correlations of PC risk and the individual plasma proteome known for minimally cancer biomarkers, are scarce. Here, we measure 1,345 human plasma proteins via Proteome-Wide Association Studies, presenting 78 proteins are prominently related to PC risk, including 4 proteins (ROR1, FN1, APOA5, ABO) exhibit the strongest causal association identified via Mendelian Randomization and Colocalization. Our two independent cohorts further demonstrate FN1 and ABO are highly expressed in blood or tumors from patients with PC compared to specimens from healthy individuals or para-tumors. Moreover, patients with higher levels of FN1 and ABO in their blood or tumors have worse median survival than those with lower levels. Multiple drugs targeting FN1 are currently available or undergoing clinical testing, making FN1 a promisingly repurposed therapeutic target in addition to severing as a circulating prognostic indicator for PC.

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“…Однако имеются данные, что при ХЗП содержание ММП-1, -9 и ТИМП-1 в крови, наоборот, снижается с утяжелением фиброза, становясь минимальным при фиброзе F3-4 [10,14,16]. У больных хроническим гепатитом С коллагеназная активность ММП уменьшается до минимальных значений при фиброзе F2-4, а желатиназная активность не определяется при любой стадии фиброза [14].…”

Section: Discussionunclassified

“…Отмечается как наличие [8,9], так и отсутствие корреляции [10,1] плазменных уровней ММП и ТИМП с гистологической активностью заболеваний печени. Представлены данные об увеличении [12][13][14][15], снижении [10,11,16] или об отсутствии связи циркулирующих в крови ММП и ТИМП [9,17,18] с печеночным фиброзом. Также до настоящего времени не определена возможность ММП и ТИМП прогнозировать тяжесть воспаления и фиброза печени.…”

Section: Introductionunclassified

Matrix metalloproteinases and morphological features in chronic liver diseases

Yagoda,

Koroy,

Dudov

2024

jour

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Aim of investigation. To study the relationship of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) with a morphological features of chronic liver diseases (CLD). Materials and methods. 76 patients with CLD of viral or alcoholic etiology aged from 18 to 64 years were examined. Chronic hepatitis was diagnosed in 59 patients, liver cirrhosis (class A according Child-Pugh score) was detected in 17 cases. The control group consisted of 72 practically healthy people. The blood levels of MMP-1, MMP-9, TIMP-1 were determined by enzyme immunoassay, and the ratio of TIMP-1/MMP-1, TIMP-1/MMP-9 was calculated. Results. There was an increase in the concentration of TIMP-1 and MMP-1 in the blood, the ratio of TIMP-1/MMP-9, a decrease in the ratio of TIMP-1/MMP-1 in CLD. In moderate and severe histological activity of CLD the levels of TIMP-1 and MMP-9 were higher, and the ratio of TIMP-1/MMP-9 was lower than in patients with histological activity index values less than 9 points. In patients with liver cirrhosis (fibrosis F4), the maximum values of TIMP-1, TIMP-1/MMP-1 and TIMP-1/MMP-9 were determined, which differed from the corresponding values for fibrosis F0-1 and F2. The blood levels of MMP-9 more than 410 ng/ml predicted severe inflammation in CLD with an accuracy of 82.9 %. The blood levels of TIMP-1 above 624 ng/ml, TIMP-1/MMP-1 more than 37.1, TIMP-1/MMP-9 more than 7.33 had high accuracy (82.9, 80.3, 80.3 %, respectively) in the prediction of liver cirrhosis (fibrosis F4). Conclusion. The imbalance in the matrix metalloproteinase system is associated with the morphological features of CLD and is characterized by hyperexpression of MMP-9 in cases of severe inflammation and increased activity of TIMP-1 in severe stages of liver fibrosis.

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Diagnostic role of collagen-III and matrix metalloproteinase-1 for early detection of hepatocellular carcinoma

Cited by 9 publications

References 32 publications

Collagen Family as Promising Biomarkers and Therapeutic Targets in Cancer

Collagen Family as Promising Biomarkers and Therapeutic Targets in Cancer

Unveiling Circulating Targets in Pancreatic Cancer: Insights from Proteogenomic Evidence and Clinical Cohorts

Matrix metalloproteinases and morphological features in chronic liver diseases

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