Diagnostic role of Gallium-68 DOTATOC and Gallium-68 DOTATATE PET in patients with neuroendocrine tumors: a meta-analysis

Abstract

The molecular imaging agents 68Ga-DOTATOC and 68Ga-DOTATATE demonstrated high sensitivity and specificity in the diagnosis of NETs on PET scan. Although both are accurate tools in the diagnosis of NETs, 68Ga-DOTATATE PET may be more sensitive and specific than 68Ga-DOTATOC PET scan.

64Cu-DOTATATE for Noninvasive Assessment of Atherosclerosis in Large Arteries and Its Correlation with Risk Factors: Head-to-Head Comparison with 68Ga-DOTATOC in 60 Patients

“…When the peptides are labeled with 67 Ga, they both bind to the somatostatin receptor 2 with exceptional affinity; however, binding is highest for DOTATATE (7). On the basis of this and previous studies (7,14,28,29), we would expect an uptake of both tracers in regions with plaque formations and furthermore that, in our case, the 64 Cu-labeled DOTATATE would show higher focal uptake in the aorta than 68 Ga-DOTATOC.…”

The Rate and Clinical Significance of Incidental Thyroid Uptake as Detected by Gallium-68 DOTATATE Positron Emission Tomography/Computed Tomography

“…The sensitivity and specificity of detecting NETs has been reported to be as high as 96% and 100%, respectively (5,6). Several Ga-68 DOTA peptides (DOTA-TATE, DOTATOC, DOTANOC) have been used, with DOTATATE found to be the most accurate (5).…”

“…The sensitivity and specificity of detecting NETs has been reported to be as high as 96% and 100%, respectively (5,6). Several Ga-68 DOTA peptides (DOTA-TATE, DOTATOC, DOTANOC) have been used, with DOTATATE found to be the most accurate (5). While there is some published research on Ga-68 DOTATATE PET/ computed tomography (CT) scanning in patients with medullary thyroid cancer and differentiated thyroid cancer to 1 Endocrine Oncology Branch, National Cancer Institute; 3 Diabetes, Obesity, and Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases; 2 PET Department, Clinical Center; National Institutes of Health, Bethesda, Maryland.…”

The future: diagnostic and imaging advances in MEN1 therapeutic approaches and management strategies

“…Ga-68-DOTATOC-PET/CT has proven to be a highly sensitive and specific technique for imaging of well-differentiated NENs. The technique showed high sensitivity of 93-96% and specificity of 85-100% for sporadic pNEN (Yang et al 2014). Superior spatial resolution, faster imaging, lower radiation exposure and lower costs are reasons for the replacement (Öberg & Sundin 2016).…”