Diagnostic role of <sup>99m</sup>Tc hexamethyl‐propyleneamine oxime brain single photon emission computed tomography in Sydenham's chorea

Demirören, Kaan; Taştekin, Güngör; Oran, Bülent

doi:10.1111/j.1442-200x.2004.01909.x

Cited by 14 publications

(12 citation statements)

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“…In study of seventeen patients with Sydenham chorea, 99m Tc HMPAO-SPECT performed 0 to 3 weeks from symptom onset demonstrated hyperperfusion in the basal ganglia and thalamus in 94.1% of patients and was normal in one patient. Follow-up 99m T HMPAO-SPECT performed 6–12 months later showed reduction in perfusion compared to the acute phase and perfusion of the basal ganglia and thalamus was similar to controls [60]. Although the data in Sydenham chorea is somewhat inconsistent in the acute phase because some studies indicate hyperperfusion in the basal ganglia and others demonstrate hypoperfusion, all follow-up studies after the resolution of chorea demonstrate normal perfusion.…”

Section: Single-photon Emission Computed Tomography (Spect)mentioning

confidence: 99%

Functional neuroimaging and chorea: a systematic review

Ehrlich

Walker

2017

J Clin Mov Disord

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Chorea is a hyperkinetic movement disorder consisting of involuntary irregular, flowing movements of the trunk, neck or face. Although Huntington’s disease is the most common cause of chorea in adults, chorea can also result from many other neurodegenerative, metabolic, and autoimmune conditions. While the pathophysiology of these different conditions is quite variable, recent advances in functional imaging have enabled the development of new methods for analysis of brain activity and neuronal dysfunction. In this paper we review the growing body of functional imaging data that has been performed in chorea syndromes and identify particular trends, which can be used to better understand the underlying network changes within the basal ganglia. While it can be challenging to identify whether changes are primary, secondary, or compensatory, identification of these trends can ultimately be useful in diagnostic testing and treatment in many of the conditions that cause chorea.

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Section: Single-photon Emission Computed Tomography (Spect)mentioning

confidence: 99%

Functional neuroimaging and chorea: a systematic review

Ehrlich

Walker

2017

J Clin Mov Disord

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“…Cognitive function in SC patients has not been well studied 1 . Some authors have described impairment of learning capacity, lower intellectual level, changes in response inhibition, divided attention, and planning ability tasks 2,3 . In most studies it is suggested that, there is an evidence of basal ganglia dysfunction which can be showed by morphologic and functional neuroimaging techniques 4 .…”

mentioning

confidence: 99%

Auditory P300 Event-Related Potentials in Children with Sydenham?s Chorea

Özdemir

Demirören

Demir

et al. 2014

Arq. Neuro-Psiquiatr.

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P300 event-related potentials (ERPs), objective measures related to cognitive processing, have not been studied in Sydenham's chorea (SC) patients. Purpose: To assess cognitive impairment with P300 ERPs. Method: Seventeen patients with SC and 20 unaffected healthy children were included. Stanford-Binet test was used for psychometric assessment, and odd-ball paradigm was used for auditory ERPs. Results: There was no significant difference in P300 latencies between the SC-pretreatment group, SC-posttreatment group and control group (p.0.05). Mean interpeak latencies in SC-pretreatment group and SC-posttreatment group showed significant prolongation compared with the control group (p,0.05). Mean interpeak latencies in SC-posttreatment group were significantly decreased compared with SC-pretreatment group (p,0.05). Compared to controls, patients did not show significant difference in Stanford-Binet intelligence examination. Conclusion: This report suggests that interpeak latencies and amplitudes of P300 ERPs could be useful for detecting and monitoring cognitive impairment in SC patients.Keywords: Sydenham's chorea, cognitive function, event-related potentials. RESUMOOs potenciais evento-relacionados à P300 (ERPs), medidas objetivas relacionadas ao processamento cognitivo, não foram ainda estudados em pacientes com Coreia de Sydenham (CS). Objetivo: avaliar o comprometimento cognitivo através dos ERPs P300. Método: foram incluídos 17 pacientes com CS e 20 crianças saudáveis. A avaliação psicométrica foi feita utilizando o teste de Stanford-Binet e, para os ERPs auditivos, foi usado o paradigma odd-ball. Resultados: Não houve diferença significativa nas latências P300 entre os grupos CS pré-tratamento, CS pós-tratamento e grupo controle. (p.0,05). A média das latências interpicos no grupo CS pré-tratamento e CS pós-tratamento apresentava aumento significativo em comparação aos pacientes do grupo controle (p,0,05). A média das latências interpicos no grupo CS pós-tratamento apresentava decréscimo significativo quando comparada àquela do grupo CS pré-tratamento (p,0,05). Comparados aos controles, os pacientes com CS não mostravam diferença significativa em relação aos controles ao teste de StanfordBinet. Conclusão: Este estudo sugere que as latências interpicos e as amplitudes dos ERPs P300 podem ser úteis para detectar e monitorar a ocorrência de comprometimento cognitivo em pacientes com CS.Palavras-chave: Coreia de Sydenham, função cognitiva, potenciais evento-relacionados.

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“…56 Single-photon emission computed tomography (SPECT) studies have shown hyper-or hypometabolism in the basal ganglia during acute SC. 50,57 Although these changes are usually reversible in post-streptococcal disease of the CNS, permanent changes suggesting irreversible damage are well described.…”

Section: Studies Of Adultsmentioning

confidence: 99%

“…9,36,[48][49][50] Inflammatory changes have been described only occasionally in SC, and are usually localised to the basal ganglia (rarely with contrast enhancement). [51][52][53][54] In post-streptococcal dystonia and Parkinsonism, inflammatory changes involving the basal ganglia appear to be more common.…”

Section: Studies Of Adultsmentioning

confidence: 99%

Post‐streptococcal autoimmune disorders of the central nervous system

Dale

2005

Develop Med Child Neuro

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Group A Streptococcus can induce autoimmune disease in humans with particular involvement of the heart, joints, and brain. The spectrum of post‐streptococcal disease of the central nervous system (CNS) has been widened recently and includes movement disorders (chorea, tics, dystonia, and Parkinsonism), psychiatric disorders (particularly emotional disorders), and associated sleep disorders. Neuroimaging and pathological studies indicate that the most vulnerable brain region is the basal ganglia. The immunopathogenesis of the disease is incompletely defined, and although there is some support for autoantibody‐mediated disease, several conflicting studies cast doubt on the autoantibody hypothesis. It has been speculated that post‐streptococcal autoimmunity has a role in common neuropsychiatric disease but the evidence is conflicting and routine screening of patients with Tourette syndrome and obsessive‐compulsive disorder for post‐streptococcal autoimmune abnormalities is not be recommended at present. However, post‐streptococcal disorders of the CNS remain a useful model of neuropsychiatric disease, which may improve our understanding of abnormal movements and behaviours in children.

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Diagnostic role of ^99mTc hexamethyl‐propyleneamine oxime brain single photon emission computed tomography in Sydenham's chorea

Abstract: It is suggested that brain SPECT can contribute to the diagnosis of SC as an objective tool. Resolving of the hyperperfusion at the recovery phase provides further support for the diagnosis of SC.

Cited by 14 publications

References 20 publications

Functional neuroimaging and chorea: a systematic review

Functional neuroimaging and chorea: a systematic review

Auditory P300 Event-Related Potentials in Children with Sydenham?s Chorea

Post‐streptococcal autoimmune disorders of the central nervous system

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Diagnostic role of 99mTc hexamethyl‐propyleneamine oxime brain single photon emission computed tomography in Sydenham's chorea

Abstract: It is suggested that brain SPECT can contribute to the diagnosis of SC as an objective tool. Resolving of the hyperperfusion at the recovery phase provides further support for the diagnosis of SC.

Cited by 14 publications

References 20 publications

Functional neuroimaging and chorea: a systematic review

Functional neuroimaging and chorea: a systematic review

Auditory P300 Event-Related Potentials in Children with Sydenham?s Chorea

Post‐streptococcal autoimmune disorders of the central nervous system

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Product

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Diagnostic role of ^99mTc hexamethyl‐propyleneamine oxime brain single photon emission computed tomography in Sydenham's chorea