Diagnostic Role of Testicular Fine Needle Aspiration Biopsy in Male Infertility

Al-Jitawi, Salah A.; Al-Ramahi, Sana Abdulqader; Hakooz, Bassma Ahmad

doi:10.1159/000333172

Cited by 14 publications

(10 citation statements)

References 12 publications

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“…The evaluation of male infertility involves a clinical examination of gonadal development, secondary sexual characteristics, semen analysis, hormonal investigations and morphological examination of testicular biopsy (Al‐Jitawi et al , 1997). Among them, the histopathology of testicular tissue is more valuable (Meinhard et al , 1973).…”

Section: Introductionmentioning

confidence: 99%

Comparison of fine-needle aspiration and open biopsy of testis in sperm retrieval and histopathologic diagnosis

Aridogan¹,

Bayazıt²,

Yaman³

et al. 2003

Andrologia

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This study aimed to compare the diagnostic value of testicular fine-needle aspiration (FNA) with open biopsy in infertile males with azoospermia or severe oligozoospermia and to evaluate the reliability of testicular sperm extraction by FNA. A total of 76 testes of 40 patients, 34 with azoospermia, four oligozoospermia and two patients who underwent orchidectomy as a result of cancer of prostate were included. Detailed clinical and laboratory examinations were performed and two semen analyses were obtained from each patient. A 20-ml 26 gauge 13-mm needle was used for FNA and smears were stained with May-Grunwald-Giemsa and Papanicolaou stain. An open biopsy was performed in each patient after FNA and the samples were stained with haematoxylen-eosin. Smears and histological stains were examined and compared under light microscopy by the same pathologist. In 69 of the 76 testes (90%) FNA cytology results agreed with the histology. In four testes, the aspirate was unsatisfactory and in three testes, spermatocytic arrest was found cytologically while subsequent biopsies revealed diffuse fibrosis. In 15 of 16 patients (93.7%) with normal and hypospermatogenesis, spermatozoa had been extracted by FNA. Spermatozoa could not be obtained after neither FNA nor open biopsy in the remaining 24 patients. Testicular FNA in infertile males is a simple, reliable and minimally invasive diagnostic tool. It is as effective as open biopsy for testicular sperm extraction and good results can be achieved in experienced hands.

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Section: Introductionmentioning

confidence: 99%

Comparison of fine-needle aspiration and open biopsy of testis in sperm retrieval and histopathologic diagnosis

Aridogan¹,

Bayazıt²,

Yaman³

et al. 2003

Andrologia

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“…Later on; cytological features of the seminiferous tubules were described by other authors. [7][8][9] FNAC testes did not take popularity because of limited awareness about usefulness of the technique, lake of expertise in aspiration and interpretation of the cytological variations, and the paucity of information about architectural details of cytology. The current study was to assess the diagnostic accuracy and cytological features of FNAC in determining the causes of azoospermia as compared to open testicular biopsy.…”

Section: Introductionmentioning

confidence: 99%

Fine Needle Aspiration Cytology (FNAC) Of Testis versus Open Biopsy in Cases With Azoospermia

El-Gindy¹,

Hegazy²,

ElTaweel³

et al. 2017

AIMDR

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Background: Aims: The objective of this study was to assess the diagnostic accuracy and cytological features of fine needle aspiration cytology smears (FNAC) in determining the causes of azoospermia as compared to open testicular biopsy. Methods: 35 patients with non-obstructive azoospermia were subjected to the study; the age of them was 20-40 years. Each patient was subjected to the taking history and clinical examination. Laboratory tests were done including urine analysis, three consecutive semen samples and endocrine evaluation. Then, cord block was achieved with 1% lignocaine; and fine needle aspiration was be done, then staining the smears with Leishman or hematoxylene and eosin stains. In the same sitting, testicular biopsy was taken, then Hematoxylin & Eosin (H&E)-stained sections were prepared. Histopathological and cytological evaluation was investigated; and photographs were be taken. Then, statistical analysis was performed. Results: The concordance of FNAC with open biopsy in the diagnosis of azoospermia was 100%. FNAC smears was associated with fewer complications such as bleeding, pain and hematoma than in case of open biopsy. Conclusion:The technique of testicular FNAC is simple, more than one specimen could be taken safely. FNAC is representative and correlates well with testicular biopsy histology.

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“…6 It is also invasive and traumatic especially when applied to both testes. 7 Fine needle aspiration cytology (FNAC) of testes has proved to be useful in testicular tumors as well as in non neoplastic and inflammatory conditions of testes. [6][7][8][9] However its greatest value is in evaluation Jha et al Testicular Fine Needle Aspiration in Evaluation of Male Infertility of spermatogenesis in azoospermic males, particularly in NOA, where it can conserve tissue of already failing organ.…”

Section: Introductionmentioning

confidence: 99%

“…Later cytologic features of seminiferous epithelium was described by Schenk and Schill. 2,7,10 However testicular FNA did not gain popularity then because of lack of experience of pathologists in cytologic analysis of various seminiferous tubular cells , because of fear of trauma to the testes with hematoma formation by the procedure and because cytology was unable to give information about the tubular basement membrane and status of interstitial tissue. 11 But later on many studies carried out showed that FNAC evaluated spermatogenesis of entire testes, was less invasive, report could be issued quicker and there was good cytologic-histologic correlation.…”

Section: Introductionmentioning

confidence: 99%

“…2,3,6,[12][13][14][15][16][17][18] It was also concluded that information of tubular basement membrane and interstitial tissue was of no help in evaluation of spermatogenesis. 7 Not only in diagnosis, but testicular FNA has also found therapeutic implication in assisted reproduction technique. Since the introduction of intracytoplasmic sperm injection (ICSI) in 1992, several studies of testicular sperm retrieval in azoospermic patients have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Testicular Fine Needle Aspiration in Evaluation of Male Infertility

Jha

Sayami

2009

J Nepal Med Assoc

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Fine needle aspiration cytology of superficial as well as of deep seated lesions is now well recognized in diagnosis of neoplastic as well as nonneoplastic and inflammatory lesions. Recently it has also gained popularity for its diagnostic and therapeutic role in male infertility. The purpose of this article was to review various studies published on role of testicular fine needle testicular cytology in male infertility and provide a brief information on method of testicular fine needle aspiration, interpretation of testicular fine needle aspiration cytology for evaluation of spermatogenesis, its advantages, limitations and complications as compared to testicular biopsy.

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Diagnostic Role of Testicular Fine Needle Aspiration Biopsy in Male Infertility

Cited by 14 publications

References 12 publications

Comparison of fine-needle aspiration and open biopsy of testis in sperm retrieval and histopathologic diagnosis

Comparison of fine-needle aspiration and open biopsy of testis in sperm retrieval and histopathologic diagnosis

Fine Needle Aspiration Cytology (FNAC) Of Testis versus Open Biopsy in Cases With Azoospermia

Testicular Fine Needle Aspiration in Evaluation of Male Infertility

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