Diagnostic scores and scales for appraising Nonalcoholic fatty liver disease and omics perspectives for precision medicine

Pérez-Díaz-del-Campo, Nuria; Martínez-Urbistondo, Diego; Bugianesi, Elisabetta; Martínéz, J. Alfredo

doi:10.1097/mco.0000000000000849

Cited by 7 publications

(4 citation statements)

References 62 publications

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“…In our study, we found that several noninvasive hepatic scores, which assessed different aspect and morbid features [ 26 ], appeared to be related to obesity in youngsters. Some indices have not been validated in children and might not be suitable for detecting and monitoring MASLD in children, but they may provide valuable information on different aspects of liver disease, such as composition, function, and lipid metabolism in clinical practice [ 57 ].…”

Section: Discussionmentioning

confidence: 95%

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Sleep duration is associated with liver steatosis in children depending on body adiposity

de Cuevillas,

Lubrecht,

Navas-Carretero

et al. 2023

Eur J Pediatr

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Sleep is a factor associated with overweight/obesity risk, wherein interactions with fatty liver should be ascertained. The aim of this cross-sectional study was to analyze the possible relationships of sleep with liver health and whether this interplay is related to body adiposity distribution in children and adolescents. Anthropometric, clinical, and biochemical measurements were performed in children and adolescents (2–18 years old) with overweight/obesity (n = 854). Body fat distribution was clinically assessed, and several hepatic markers, including hepatic steatosis index, were calculated. Sleep time mediation (hours/day) in the relationship between the hepatic steatosis index and body fat distribution was investigated. Differences among diverse fatty liver disease scores were found between children with overweight or obesity (p < 0.05). Linear regression models showed associations between hepatic steatosis index and lifestyle markers (p < 0.001). Hepatic steatosis index was higher (about + 15%) in children with obesity compared to overweight (p < 0.001). Pear-shaped body fat distribution may seemingly play a more detrimental role on liver fat deposition. The association between sleep time and hepatic steatosis index was dependent on body mass index z-score. Post hoc analyses showed that 39% of the relationship of body fat distribution on hepatic steatosis index may be explained by sleep time. Conclusion: An association of sleep time in the relationship between body fat distribution and hepatic steatosis index was observed in children and adolescents with overweight/obesity, which can be relevant in the prevention and treatment of excessive adiposity between 2 and 18 years old. Clinical trial: NCT04805762. Import: As part of a healthy lifestyle, sleep duration might be a modifiable factor in the management of fatty liver disease in children. What is Known:• Sleep is an influential factor of overweight and obesity in children.• Excessive adiposity is associated with liver status in children and adolescents. What is New:• Sleep time plays a role in the relationship between body fat distribution and liver disease.• Monitoring sleep pattern may be beneficial in the treatment of hepatic steatosis in children with excessive body weight.

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Section: Discussionmentioning

confidence: 95%

“…Different indirect hepatic markers have been calculated, considering the necessary criteria and applying accepted formulas [ 26 ]. The equations are shown in Supplementary Table 1 .…”

Section: Methodsmentioning

confidence: 99%

Sleep duration is associated with liver steatosis in children depending on body adiposity

de Cuevillas,

Lubrecht,

Navas-Carretero

et al. 2023

Eur J Pediatr

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“…Nevertheless, biopsy or genetic studies are too risky, expensive, and complicated to be efficient in the risk factor scenario [ 44 ]. Thus, hepatic steatosis may be considered a surrogate metric for metabolic risk when evaluated through non-invasive techniques such as ultrasound, MRI, and transient elastography [ 45 , 46 ] and even validated serologic indices [ 47 ]. Several epidemiological studies have explored the association between non-invasively assessed SLD and metabolic and cardiovascular risk regarding quality of life [ 48 ], as well as the impact of lifestyle modification [ 49 ], incidence of T2DM [ 50 ], and incidence of cardiovascular events [ 51 ].…”

Section: Liver Steatotic Disease As a Potential Residual Cardiovascul...mentioning

confidence: 99%

Bridging Metabolic-Associated Steatotic Liver Disease and Cardiovascular Risk: A Potential Role for Ketogenesis

del Villar-Carrero,

Blanco,

Ruiz

et al. 2024

Biomedicines

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The prevalence of cardiovascular diseases (CVDs) is a growing global health concern. Recent advances have demonstrated significant reductions in acute cardiovascular events through the management of modifiable cardiovascular risk factors. However, these factors are responsible for about 50% of the global cardiovascular disease burden. Considering that CVDs are one of the top mortality causes worldwide, the concept of residual cardiovascular risk is an important emerging area of study. Different factors have been proposed as sources of residual risk markers, including non-HDL particles characterization, as well as inflammation measured by serum and imaging technics. Among these, metabolic-associated steatotic liver disease (MASLD) remains controversial. Two opposing viewpoints contend: one positing that fatty liver disease merely reflects classical risk factors and thus adds no additional risk and another asserting that fatty liver disease independently impacts cardiovascular disease incidence. To address this dilemma, one hypothetical approach is to identify specific hepatic energy-yielding mechanisms and assess their impact on the cardiovascular system. Ketogenesis, a metabolic intermediate process particularly linked to energy homeostasis during fasting, might help to link these concepts. Ketogenic metabolism has been shown to vary through MASLD progression. Additionally, newer evidence supports the significance of circulating ketone bodies in cardiovascular risk prediction. Furthermore, ketogenic metabolism modification seems to have a therapeutic impact on cardiovascular and endothelial damage. Describing the relationship, if any, between steatotic liver disease and cardiovascular disease development through ketogenesis impairment might help to clarify MASLD’s role in cardiovascular risk. Furthermore, this evidence might help to solve the controversy surrounding liver steatosis impact in CVD and might lead to a more accurate risk assessment and therapeutic targets in the pursuit of precision medicine.

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“…Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver condition characterized by the accumulation of excess fat in the liver, not caused by excessive alcohol consumption [1]. With its increasing prevalence globally, NAFLD has emerged as a significant public health concern [2]. Lifestyle factors play a crucial role in the development and progression of NAFLD, highlighting the importance of maintaining the high-quality lifestyle for both liver health and overall well-being [3].…”

Section: Introductionmentioning

confidence: 99%

Impact of Health Related QoL and Mediterranean Diet on Liver Fibrosis in Patients with NAFLD

et al. 2023

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Patients with non-alcoholic fatty liver disease (NAFLD) display impaired health-related quality of life (HRQoL) that is often linked to an unhealthy dietary pattern. The aim of this work was to investigate the impact of HRQoL and adherence to the Mediterranean diet on the risk of liver fibrosis (LF) in patients with NAFLD. LF was assessed in 244 patients through transient elastography (FibroScan®530. Echosens, Paris, France). Significant LF was defined according to liver stiffness measurements (LSM) values ≥ 7.1 kPa. The Mediterranean diet score and the Short Form-36 questionnaires were also completed. The median age was 54 (44–62) years and 57% of participants were male. A total of 42 (17.2%) participants had LSM ≥ 7.1 kPa and showed increased GGT (p = 0.001), glucose (p < 0.001), and triglycerides levels (p = 0.015) compared to those with LSM ≤7.0 kPa. Moreover, patients with significant LF had significantly lower scores related to Physical Functioning (p < 0.001) and Role Physical (p < 0.001). In the logistic regression analysis, lower role physical and lower adherence to the MedDiet (p = 0.001 and p = 0.009, respectively), after adjusting for age, diabetes, and obstructive sleep apnea, were associated with an increased risk of significant LF. Low adherence to MedDiet and low role physical may influence the risk of significant liver fibrosis in patients with NAFLD.

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Diagnostic scores and scales for appraising Nonalcoholic fatty liver disease and omics perspectives for precision medicine

Cited by 7 publications

References 62 publications

Sleep duration is associated with liver steatosis in children depending on body adiposity

Sleep duration is associated with liver steatosis in children depending on body adiposity

Bridging Metabolic-Associated Steatotic Liver Disease and Cardiovascular Risk: A Potential Role for Ketogenesis

Impact of Health Related QoL and Mediterranean Diet on Liver Fibrosis in Patients with NAFLD

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