Diagnostic sensitivity of SPECT myocardial perfusion imaging using a pumping cardiac phantom with inserted variable defects

Chrysanthou-Baustert, Isabelle; Parpottas, Yiannis; Demetriadou, Ourania; Christofides, Stelios; Yiannakkaras, Charalambos; Kaolis, Demetris; Wasilewska-Radwańska, Marta; Fiutowski, T.; Sikora, Franciszek

doi:10.1007/s12350-013-9726-y

Cited by 13 publications

(7 citation statements)

References 10 publications

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“…Celler et al 24 , investigated the impact of attenuation and truncation on a SPECT system with a helical CT using various sizes of water bags placed on an anthropomorphic phantom modeling various patient sizes in the absence of respiratory motion. In a recent paper, Chrysanthou-Baustert et al 25 , also performed phantom acquisitions on a SPECT system (Forte-SLS) modeling different patients sizes, which employed a pumping cardiac phantom. Segars et al 26 , performed computer simulations of different CT scanners with varying rotation speeds for different extents of respiratory amplitudes.…”

Section: Discussionmentioning

confidence: 99%

Comparison of methods of acquiring attenuation maps for cardiac SPECT in the presence of respiratory motion

Könik

Kikut

Lew

et al. 2013

Journal of Nuclear Cardiology

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Background We investigated the effect of the respiratory motion on attenuation-corrected (AC) SPECT images for three different SPECT systems, each using a different approach in obtaining attenuation maps: scanning-line sources (SLS) acquired simultaneous with emission; slow cone-beam CT (CBCT) acquired sequentially to emission; and fast helical CT (HCT) acquired sequentially to emission. Methods A torso phantom filled with 99mTc was used to model a cardiac perfusion study. Stationary baseline acquisitions were followed by the acquisitions with the phantom moving axially using a computer-controlled motion platform to simulate breathing. In addition, HCT acquisitions were made simulating breath-hold at different extents of misalignment between CT and emission. HCT images were also used to simulate the Average-CT method. Acquisitions were repeated with added breast attachments, and the heart insert in two different orientations. Visual comparison was made of AC maps, AC emission slices and polar maps. Quantitative comparisons were made of global uniformity based on the percent fractional standard deviation (%FSD) of the polar map segment values, and the ratio of the segment values in the Anterior and Inferior walls divided by that of the Lateral and Septal walls (AI/LS ratio). Results The AC maps for the SLS were inferior to the CT’s, and most impacted by added large breast attachment. Motion artifacts seen on CBCT slices were minimized in the derived attenuation maps. AC maps obtained from HCT showed inconsistent organ sizes depending on the direction of respiration at the time of acquisition. Both visually and quantitatively CBCT resulted in the best uniformity (up to 3.4 % lower in %FSD) for all the stationary acquisitions, and for the motion acquisition of the female phantom with large breast attachment (up to 4.0 % lower). For the motion acquisition of the male phantoms, HCT resulted in slightly better uniformity (<0.5 % lower) than CBCT. Breath-hold at end-expiration slightly improved (up to 1.1 %) the uniformity over the HCT acquired during regular breathing. Further improvement was achieved with the Average-CT method. For all the systems, phantom respiratory motion reduced the AI/LS ratio compared to when the phantoms were stationary. Conclusions The CBCT approach resulted in the best uniformity of the AC emission images. For the female phantom with larger breast attachment, HCT and SLS were truncated at some projection angles introducing artifacts into the AC emission images. The emission image artifacts observed with HCT could be mitigated by performing breath-hold acquisition at end-expiration or Average-CT type acquisitions. (J Nucl Cardiol 2013)

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Section: Discussionmentioning

confidence: 99%

Comparison of methods of acquiring attenuation maps for cardiac SPECT in the presence of respiratory motion

Könik

Kikut

Lew

et al. 2013

Journal of Nuclear Cardiology

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“…A cardiac phantom of an ECG beating and moving left ventricle with variable defects, and a respiratory phantom of inflatable lungs, constructed at Frederick Research Center, were inserted into an anthropomorphic thorax phantom 12 and used to simulate the heart motion during respiration using routine imaging conditions.…”

Section: Phantom Assemblymentioning

confidence: 99%

Impact of respiratory motion correction on SPECT myocardial perfusion imaging using a mechanically moving phantom assembly with variable cardiac defects

Polycarpou

Chrysanthou-Baustert

Demetriadou

et al. 2017

Journal of Nuclear Cardiology

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“…In the past, multiple phantom models have provided useful information regarding the effectiveness of AC models [28]. However, true validation is provided by clinical trials showing the increased diagnostic performance of AC techniques in several populations.…”

Section: The Evidencementioning

confidence: 99%

Is Attenuation Correction for Myocardial Perfusion Imaging Underutilized?

Kauling

Post

Rensing

et al. 2015

Curr Cardiovasc Imaging Rep

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Myocardial SPECT remains an important diagnostic technique in patients suspected of significant coronary artery disease. However, the diagnostic accuracy is hampered by several clinical and technical difficulties. Among these, soft tissue attenuation is one of the most frequent causes. Attenuation correction has the power to correct for these artifacts, increasing the diagnostic accuracy of myocardial SPECT. The current review summarizes the available clinical evidence for attenuation correction and raises the question if this technique is not underutilized in current clinical practice.

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Diagnostic sensitivity of SPECT myocardial perfusion imaging using a pumping cardiac phantom with inserted variable defects

Abstract: The diagnostic sensitivity was improved when applying AC or GSPECT techniques.

Cited by 13 publications

References 10 publications

Comparison of methods of acquiring attenuation maps for cardiac SPECT in the presence of respiratory motion

Comparison of methods of acquiring attenuation maps for cardiac SPECT in the presence of respiratory motion

Impact of respiratory motion correction on SPECT myocardial perfusion imaging using a mechanically moving phantom assembly with variable cardiac defects

Is Attenuation Correction for Myocardial Perfusion Imaging Underutilized?

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