Diagnostic significance of anti-annexin-A5 antibody determination

Abstract

<jats:title>Abstract</jats:title><jats:p>Anti-annexin A5 antibodies are directed against annexin A5 — a phospholipid-binding protein that belongs to the ubiquitous annexin family. These antibodies were first discovered in 1994 by Matsuda et al. in women with recurrent fetal loss or preeclampsia and in patients with systemic lupus erythematosus and positive lupus anticoagulant and/or anticardiolipin antibodies. Since then anti-annexin A5 antibodies have been the focus of research. In addition to their well known prothrombotic and procoagulant activities the authors discuss the involvement of these antibodies in the pathogenesis of antiphospholipid syndrome, recurrent pregnancy loss, systemic lupus erythematosus and other immune and non-immune disorders. Controversial reports are presented and a possible interpretation of the results is given. The authors suggest the significance of anti-annexin A5 antibodies as an additional diagnostic marker and discuss the necessity of more extensive research on their clinical significance.</jats:p>

Descripción de la presencia de anticuerpos antianexina V, cardiolipina y B2-glicoproteína I en mujeres con pérdidas gestacionales recurrentes en la ciudad de Medellín, Colombia

“…Las pacientes positivas o indeterminadas para anexina no presentaron anticuerpos contra ß 2-GPI. Este hallazgo puede sugerir que la anexina V es un factor importante e independiente de los anticuerpos anticardiolipina y ß 2-GPI en las pérdidas gestacionales recurrentes como se ha reportado en trabajos anteriores (28).…”

“…Respecto a la importancia clínica de los anticuerpos antianexina V, muchos autores sugieren que son un marcador diagnóstico en pacientes con trombosis, problemas reproductivos y enfermedades autoinmunes como lupus eritematoso sistémico, artritis reumatoide y SAF (12)(13)(14). La presencia de anticuerpos contra esta proteína se relaciona con pérdida gestacional recurrente debido a procesos trombóticos e isquémicos en la placenta, dado que la anexina V inhibe la activación de la protrombina de manera que previene la formación de trombos en condiciones normales de flujo venoso o arterial (6,15,16). Además, posee efecto antiinflamatorio e inhibe la proteinkinasa C (17)(18)(19)(20).…”

Anti-annexin V Antibodies in Women with Recurrent Miscarriage

“…Annexin V is also known as placental anticoagulant protein I, is located on the apical surface of the placental syncytiotrophoblast and, with the development of the placenta during pregnancy, a massive exposition of A5 to the circulating immune cells could occur. 8…”

“…Some authors focus their efforts on animal models and investigate fundamental issues concerning the role of annexin antibodies in the process of thrombogenesis. 8…”