Diagnostic testing for <scp>COVID</scp>‐19: demonstrated utility of duplicate testing for inpatients in a low incidence setting

Griffin, David; Bramwell, Eliza; Cheng, Allen; Spelman, Denis

doi:10.1111/imj.15083

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…The absolute performance of the screening plans increases with the sensitivity of the individual tests used, but their relative performance remains unchanged. It should be noticed that the sensitivity value of 0.9 roughly corresponds to the one that would be obtained by repeating a test with a sensibility of 0.7 twice on the same individual, in a procedure of double testing [6,27].…”

Section: Plos Onementioning

confidence: 99%

Screening plans for SARS-CoV-2 based on sampling and rotation: An example in a European school setting

Baccini

Cereda

2021

PLoS ONE

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Screening plans for prevention and containment of SARS-CoV-2 infection should take into account the epidemic context, the fact that undetected infected individuals may transmit the disease and that the infection spreads through outbreaks, creating clusters in the population. In this paper, we compare through simulations the performance of six screening plans based on poorly sensitive individual tests, in detecting infection outbreaks at the level of single classes in a typical European school context. The performance evaluation is done by simulating different epidemic dynamics within the class during the four weeks following the day of the initial infection. The plans have different costs in terms of number of individual tests required for the screening and are based on recurrent evaluations on all students or subgroups of students in rotation. Especially in scenarios where the rate of contagion is high, at an equal cost, testing half of the class in rotation every week appears to be better in terms of sensitivity than testing all students every two weeks. Similarly, testing one-fourth of the students every week is comparable with testing all students every two weeks, despite the first one is a much cheaper strategy. In conclusion, we show that in the presence of natural clusters in the population, testing subgroups of individuals belonging to the same cluster in rotation may have a better performance than testing all the individuals less frequently. The proposed simulations approach can be extended to evaluate more complex screening plans than those presented in the paper.

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Section: Plos Onementioning

confidence: 99%

Screening plans for SARS-CoV-2 based on sampling and rotation: An example in a European school setting

Baccini

Cereda

2021

PLoS ONE

View full text Add to dashboard Cite

show abstract

Screening plans for SARS-CoV-2 based on sampling and rotation: an example in the school setting

Baccini

Cereda

2021

Preprint

View full text Add to dashboard Cite

Screening plans for prevention and containment of SARS-CoV-2 infection should take into account the epidemic context, the fact that undetected infected individuals may transmit the disease, and that the infection spreads through outbreaks, creating clusters in the population. In this paper, we compare the performance of six screening plans based on poorly sensitive individual tests, in detecting infection outbreaks at the level of single classes in a school context. The performance evaluation is done by simulating different epidemic dynamics within the class during the five weeks following the day of the first infection. The plans have different costs in terms of number of individual tests required for the screening and are based on recurrent evaluations on all students or subgroups of students in rotation. Especially in scenarios where the rate of contagion is high, at an equal cost, testing half of the class in rotation every week appears to be better in terms of sensitivity than testing all students every two weeks. Similarly, testing one-fourth of the students every week is comparable with testing all students every two weeks, despite the first one is a much cheaper strategy. In the presence of natural clusters in the population, testing subgroups of individuals belonging to the same cluster in rotation may have a better performance than testing all the individuals less frequently. The proposed simulations approach can be extended to evaluate more complex screening plans than those presented in the paper.

show abstract

Diagnostic testing for COVID‐19: demonstrated utility of duplicate testing for inpatients in a low incidence setting

Cited by 2 publications

References 4 publications

Screening plans for SARS-CoV-2 based on sampling and rotation: An example in a European school setting

Screening plans for SARS-CoV-2 based on sampling and rotation: An example in a European school setting

Screening plans for SARS-CoV-2 based on sampling and rotation: an example in the school setting

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