Diagnostic tests for H. pylori: A prospective evaluation of their accuracy with an independent “gold standard”

Thijs, J. C.; Zwet, A. A. Van; Thijs, W J; Oey, HB; Karrenbeld, Arend; Stellaard, Frans; Luijt, D.; Meyer, BC; Kleibeuker, JH

doi:10.1016/0016-5085(95)23623-6

Cited by 102 publications

(172 citation statements)

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“…35 The 13 carbon-urea breath test presented a high occurrence of false results: 4 false positive and 2 false negative results. Despite the high sensitivity and specificity described for the method, 26,27,39 our results (sensitivity = 93.1% and specificity = 78.9%) were lower than observed in other studies, especially by Thijs et al, 27 who observed 100% sensitivity and specificity in a similar study among adults. The sensitivity, moreover, presents results closer to those described by Vandenplas et al, 26 who evaluated pediatric patients.…”

Section: Discussioncontrasting

confidence: 74%

“…33 This lower concordance is due to the occurrence of a high number of false results, as observed in Table 1: fifteen patients (32%) presented one discordant result, with this result being positive in 7 (patients 11-17) and negative in 8 (patients [21][22][23][24][25][26][27][28], which suggest these results may be false. But when more than one method presents discordance it is necessary to analyze carefully the methods and criteria used to classify the patient.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of invasive and non-invasive methods for the diagnosis of Helicobacter pylori infection in symptomatic children and adolescents

et al. 2001

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Section: Discussioncontrasting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Evaluation of invasive and non-invasive methods for the diagnosis of Helicobacter pylori infection in symptomatic children and adolescents

et al. 2001

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“…Six commonly used tests to detect H. pylori are the histological examination, microbial culture, poly-merase chain reaction, rapid urease test, serology (ELISA) and 13C-urea breath test. 6 The histopathologic detection is still considered to be the gold standard for the diagnosis of H. pylori. 7 Use of more than one diagnostic method improves H. pylori detection rate.…”

Section: Ar Khan An Age-and Gender-specific Analysis Of H Pylori Inmentioning

confidence: 99%

An Age- and Gender-Specific Analysis of H. Pylori Infection

Khan

1998

Ann Saudi Med

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The objective of this study was to determine the incidence of Helicobacter pylori infection in different age and sex groups from the southern region of Saudi Arabia, and to relate the results to the high incidence of gastric cancer in this region. The carcinogenic effect of H. pylori is considered to be age-dependent. H. pylori infection early in life predisposes patients to gastric cancer. In contrast, acquisition of infection later in life leads to development of duodenal ulcer. We studied 528 consecutive endoscopic biopsies over a period from March 1995 to August 1996. The presence or absence of H. pylori was tabulated according to age and sex of the patients. Three hundred and fifty-three (67%) of 528 patients were positive for H. pylori. There were 313 males, among whom 217 (69%) were positive. There were 215 females, among whom 136 (63%) were positive for H. pylori. The presence of H. pylori in various age groups was as follows: under 16 years, 62%; 16 to 25 years, 67%; 26-35 years, 69%; 36-45 years, 67%; 46-55 years, 66%; and 56 years and above, 65%. Statistical analysis revealed no significant difference between the groups. No significant rise in the infection rate was noted from childhood to advanced age. These data support the belief that H. pylori infection was acquired early in life, leading to multifocal gastritis and thus predisposing the patients to gastric cancer later in life. However, H. pylori may not be the single agent of gastric cancer inasmuch as the infection affects both genders equally, whereas gastric cancer has a male preference. Perhaps some additional factors augment the pivotal role of

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“…There are many ways of testing: serology, 13 C-urea breath test and faecal antigen test. Compared with histology, it is estimated that the 13 C-urea breath test is 95% sensitive and 95% specific when diagnosing H. pylori infections [63]. Elwyn et al [64] performed a cost effectiveness analysis and concluded that serology is less accurate than the 13 C-urea breath test and the faecal antigen test, because it is not able to distinguish between present and past infections.…”

Section: Monitoring Of Drug Treatment Effectsmentioning

confidence: 99%

Applications of stable isotopes in clinical pharmacology

Schellekens

Stellaard

Woerdenbag

et al. 2011

Brit J Clinical Pharma

105

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This review aims to present an overview of the application of stable isotope technology in clinical pharmacology. Three main categories of stable isotope technology can be distinguished in clinical pharmacology. Firstly, it is applied in the assessment of drug pharmacology to determine the pharmacokinetic profile or mode of action of a drug substance. Secondly, stable isotopes may be used for the assessment of drug products or drug delivery systems by determination of parameters such as the bioavailability or the release profile. Thirdly, patients may be assessed in relation to patient-specific drug treatment; this concept is often called personalized medicine. In this article, the application of stable isotope technology in the aforementioned three areas is reviewed, with emphasis on developments over the past 25 years. The applications are illustrated with examples from clinical studies in humans.

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Diagnostic tests for H. pylori: A prospective evaluation of their accuracy with an independent “gold standard”

Cited by 102 publications

References 0 publications

Evaluation of invasive and non-invasive methods for the diagnosis of Helicobacter pylori infection in symptomatic children and adolescents

Evaluation of invasive and non-invasive methods for the diagnosis of Helicobacter pylori infection in symptomatic children and adolescents

An Age- and Gender-Specific Analysis of H. Pylori Infection

Applications of stable isotopes in clinical pharmacology

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