Diagnostic tools in Rhinology EAACI position paper

Scadding, Glenis; Hellings, Peter W.; Alobid, Isam; Bachert, Claus; Fokkens, Wytske J.; Wijk, Roy Gerth van; Gevaert, Philippe; Guilemany, J.M.; Kalogjera, Livije; Lund, Valerie J.; Mullol, Joaquim; Passalacqua, Giovanni; Toskala, Elina; Drunen, Cornelis M. van

doi:10.1186/2045-7022-1-2

Cited by 191 publications

(193 citation statements)

References 145 publications

(174 reference statements)

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“…Two schoolchildren from the control group were unable to adequately coordinate breathing to enable measurement of nasal resistance and had to withdraw from the study. This finding had been reported by others and pointed out as one of the main advantages of AR over AAR [5,8].…”

Section: Resultssupporting

confidence: 49%

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Acoustic Rhinometry in Nasal Provocation Tests in Children and Adolescents

Gf¹,

Ai²,

Matsumoto³

et al. 2016

J Investig Allergol Clin Immunol

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Objectives: To standardize acoustic rhinometry (AR) in nasal provocation tests (NPTs) with histamine in children and adolescents. Patients and Methods: We performed a cross-sectional validation to compare AR with anterior active rhinomanometry (AAR) during histamine NPT in 20 children and adolescents with persistent allergic rhinitis and 20 controls. Changes in total nasal resistance (AAR) were compared with changes in nasal volume in the first 5 cm (V5 ; P=.04) at baseline. The mean histamine concentration necessary to increase total nasal resistance by at least 100% was significantly lower in the rhinitis group than in the control group (0.72 mg/mL vs 2.4 mg/mL; P<.001). At the end of the NPT a mean increase of 126% in total nasal resistance and a mean decrease of 24.3% in V5 were observed in the rhinitis group. When compared with the AAR criteria, the highest sensitivity and specificity values were observed for a cutoff represented by a 19%-21% drop in V5. Conclusions: We found AR to be a feasible and sensitive tool for monitoring nasal response in children and adolescents undergoing histamine NPT. The best AR cutoff for ending the NPT was a 19%-21% drop in V5. Key words: Rhinitis. Nasal provocation tests. Histamine. Acoustic rhinometry. Rhinomanometry. Nasal cavity. Airway resistance. ResumenObjetivos: Estandarizar la rinometría acústica (RA) como medida de la respuesta a la prueba de provocación nasal con histamina (PPN) en niños y adolescentes. Pacientes y métodos: Se realizó un estudio de validación transversal comparando la RA frente a la rinomanometría anterior (RAA) activa en la evaluación de la respuesta frente a la PPN con histamina, realizado en 20 niños o adolescentes, diagnosticados de rinitis alérgica persistente y 20 controles sanos. Las variables estudiadas fueron los cambios en la resistencia nasal total, medida mediante RAA y los cambios en el volumen nasal de los primeros 5 cm (V5) evaluados mediante RA. Resultados: En relación con los sujetos control, los pacientes con rinitis alérgica presentaban niveles basales de resistencia nasal total significativamente más elevados (medias respectivas 0,34 Pa/cm 3 /s versus 0,21 Pa/cm 3 /s; p= 0,01) y valores de V5 significativamente inferiores (medias respectivas 8,20 cm 3 versus 9,24 cm 3 ; p= 0,04). La concentración media de histamina necesaria para incrementar el 100% la resistencia total nasal fue significativamente más baja en los pacientes con rinitis que en los controles (medias respectivas 0,72 mg/ml versus 2,4 mg/ml; p< 0,001). Al final de la PPN el incremento medio de la resistencia nasal total fue del 126%, en los sujetos con rinitis alérgica. En ese momento también se observó en este grupo un decremento medio del V5 del 24,3%. Utilizando como patrón oro de respuesta positiva un incremento en la resistencia nasal total del 100% mediante RAA, los puntos de corte con mayor sensibilidad y especificidad para el descenso de V5 se encontraban en un descenso de entre el 19 y 21%. Conclusiones: Nuestros resultados demuestran que la RA es ...

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Section: Resultssupporting

confidence: 49%

“…Unlike other techniques, AR does not depend on patient cooperation and is considered suitable for the study of children [7,8]. Several studies have shown that evaluation of nasal volumes using AR is reliable and reproducible [9].…”

Section: Introductionmentioning

confidence: 99%

Acoustic Rhinometry in Nasal Provocation Tests in Children and Adolescents

Gf¹,

Ai²,

Matsumoto³

et al. 2016

J Investig Allergol Clin Immunol

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“…Measurement of the maximal inspiratory air flow rate can be a convenient method of objective evaluation of the therapeutic response in patients with inferior turbinate hypertrophy [18]. Moreover, nasal inspiration is most strongly correlated with the subjective feeling of nasal obstruction, and NIPF provides a physiological measurement of the air flow through the nose [19]. In the present study, NIPF and nasal obstruction VAS scores were significantly improved in both groups after the treatment.…”

Section: Discussionsupporting

confidence: 51%

Comparison of Submucosal Resection and Radiofrequency Turbinate Volume Reduction for Inferior Turbinate Hypertrophy: Evaluation by Magnetic Resonance Imaging

Ercan

İmre

Pınar

et al. 2013

Indian J Otolaryngol Head Neck Surg

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Inferior turbinate hypertrophy is a frequent cause of nasal airway obstruction and drastically impairs patients' quality of life. Surgical reduction of the inferior turbinates can be used for patients who did not respond to medical therapy. A number of studies have been performed to identify the most effective technique. The aim of this study was to compare the effectiveness of submucosal resection (SMR) and radiofrequency turbinate volume reduction (RFTVR) in patients with inferior turbinate hypertrophy. A prospective, randomized case-control study was conducted. Sixty patients with inferior turbinate hypertrophy refractory to medical therapy were prospectively and randomly assigned to two groups: SMR and RFTVR. A visual analog scale (VAS) and the nasal inspiratory peak flow (NPIF) were analyzed pre-and postoperatively at the first week and second month. Magnetic resonance imaging was performed pre-and postoperatively at the second month. The surgical outcomes were compared statistically using subjective and objective measures. Significant turbinate volume reduction was achieved in both the SMR and RFTVR groups. However, turbinate volume reduction was significantly greater in the SMR than in the RFTVR group at the second month postoperatively. NIPF and VAS scores were improved after both procedures at the second month postoperatively. Beside this, surgical outcomes were significantly better after SMR in terms of NIPF and VAS scores. In this study, we demonstrated that both SMR and RFTVR are effective for inferior turbinate hypertrophy. Turbinate volume reduction, improvement of subjective nasal obstruction symptoms, and NIPF after SMR were significantly superior to those after RFTVR.

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“…Los criterios de inclusión fueron los siguientes: historia clínica sugestiva de alergia respiratoria a ácaros de polvo establecida por alergólogos con base en los criterios de la Global Initiative for Asthma (GINA) y de la iniciativa Allergic Rhinitis and its Impact on Asthma (ARIA) (8,17), así como en la prueba de punción positiva frente a ácaros de polvo usando extractos alergénicos estandarizados para aeroalérgenos comunes de acuerdo con la normativa internacional (18), el pico de flujo nasal inspiratorio y el pico de flujo espiratorio (19), también determinados según los parámetros internacionales estandarizados (20). Los criterios de exclusión fueron aquellos propuestos por la World Allergy Organization (WAO) para la inmunoterapia alergénica (21).…”

Section: Población De Estudiounclassified

Impacto de la Inmunoterapia subcutánea con Dermatophagoides farinae y Dermatophagoides pteronyssinus sobre la calidad de vida de pacientes con rinitis y asma alérgica

et al. 2014

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Contribución de los autores:Todos los autores participaron de igual forma en la atención de las pacientes, la recolección de los datos, la redacción y la corrección del manuscrito. Impacto de la inmunoterapia subcutánea conDermatophagoides farinae y Dermatophagoides pteronyssinus sobre la calidad de vida de pacientes con rinitis y asma alérgica Introducción. Como sucede en otras partes del mundo, la prevalencia de asma y rinitis alérgica en Colombia está en aumento. Se ha establecido que la inmunoterapia subcutánea con alérgenos es eficaz a largo plazo en pacientes con rinitis alérgica y asma sensibilizados a Dermophagoides. Objetivo. Proveer evidencia sobre los cambios relacionados con la calidad de vida inducidos por la inmunoterapia subcutánea en sujetos con alergia respiratoria. Materiales y métodos. Se seleccionaron 76 sujetos con diagnóstico de alergia respiratoria con sensibilización a Dermatophagoides farinae y Dermatophagoides pteronyssinus. Para la evaluación de la calidad de vida se emplearon los instrumentos Kidscreen-27 y SF-36 (Short form 36). Estos instrumentos se aplicaron en dos ocasiones: durante la primera visita, en la cual se iniciaba la inmunoterapia subcutánea, y un año después de haberse iniciado el tratamiento.Resultados. Al año de estar recibiendo la inmunoterapia, los 22 sujetos que completaron el estudio presentaron cambios positivos en términos de calidad de vida. En los niños, el principal cambio se presentó en el dominio del 'entorno escolar' mientras que en los adultos fue en el de la 'función física'. Discusión. Se evaluaron por primera vez en Colombia los beneficios inducidos por la inmunoterapia subcutánea para ácaros de polvo en la calidad de vida de sujetos con rinitis alérgica y asma mediante los cuestionarios Kidscreen-27 y SF-36. Los resultados proveen evidencia de que la inmunoterapia subcutánea influye positivamente en la calidad de vida en sujetos con rinitis asmática y asma sensibilizados a los ácaros de polvo. The impact of subcutaneous immunotherapy with Dermatophagoides farinae and Dermatophagoides pteronyssinus on the quality of life of patients with allergic rhinitis and asthma Introduction: The prevalence of asthma and allergic rhinitis in Colombia is increasing at the same rate as it is in other parts of the world. It has been determined that allergen-specific subcutaneous immunotherapy is effective in subjects with allergic rhinitis and asthma that are sensitized to house dust mites: Dermatophagoides farinae and Dermatophagoides pteronyssinus. Objective: To provide evidence on changes in the quality of life of subjects induced by allergen-specific subcutaneous immunotherapy with Dermatophagoides farinae and Dermatophagoides pteronyssinus. Materials and methods:We selected 76 subjects with a diagnosis of respiratory allergy with sensitization to Dermatophagoides farinae and Dermatophagoides pteronyssinus. The instruments used for evaluating the quality of life were Kidscreen-27 and SF-36. These instruments were applied twice for each subject: once during the fir...

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Diagnostic tools in Rhinology EAACI position paper

Cited by 191 publications

References 145 publications

Acoustic Rhinometry in Nasal Provocation Tests in Children and Adolescents

Acoustic Rhinometry in Nasal Provocation Tests in Children and Adolescents

Comparison of Submucosal Resection and Radiofrequency Turbinate Volume Reduction for Inferior Turbinate Hypertrophy: Evaluation by Magnetic Resonance Imaging

Impacto de la Inmunoterapia subcutánea con Dermatophagoides farinae y Dermatophagoides pteronyssinus sobre la calidad de vida de pacientes con rinitis y asma alérgica

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