Diagnostic usefulness of 18F-FAMT PET and L-type amino acid transporter 1 (LAT1) expression in oral squamous cell carcinoma

Abstract

(18)F-FAMT PET showed higher specificity for detecting malignant lesions than (18)F-FDG PET. The uptake of (18)F-FAMT by OSCC cells can be determined by the presence of LAT1 expression and tumour cell proliferation.

The role of L-type amino acid transporter 1 in human tumors

“…In particular, LAT1 expression is significantly correlated with L-3,4-dihydroxy-(ring-2,5,6-3H) phenylalanine ( 3 H-L-DOPA) uptake in human gliomas in vitro and 18F-DOPA uptake in vivo (21). Similar, in oral squamous cell carcinoma the uptake of 18 F-FAMT is mediated by LAT1 expression. Moreover, 18 F-FAMT positron emission tomography (PET) imaging has displayed a higher specificity at detecting malignant lesions than 2-[…”

“…Similar, in oral squamous cell carcinoma the uptake of 18 F-FAMT is mediated by LAT1 expression. Moreover, 18 F-FAMT positron emission tomography (PET) imaging has displayed a higher specificity at detecting malignant lesions than 2-[…”

Targeting L-type amino acid transporter 1 for anticancer therapy: clinical impact from diagnostics to therapeutics

“…stable expression and a high tumor-specific accumulation in the renal cells overexpressing human LAT1 [65]. In addition, it provides a useful imaging modality for detecting active myelomatous lesions in multiple myeloma patients [63] and its accumulation correlates with tumor proliferation and advanced stage in patients with oral squamous cell carcinoma [64] and NSCLC [18,24]. 18 F-d-FPHCys is a new 18 F-labeled methionine derivative developed as a PET tracer.…”

“…These include O-(2-18 F-fluoroethyl)-Ltyrosine ( 18 F-FET) [60], L-3-18 F-a-methyl tyrosine ( 18 F-FAMT) [61][62][63][64][65], 6-18 F-fluoro-L-3,4-dihydroxy-phenylalanine ( 18 F-DOPA) [42,66], S-(3-18 F-fluoropropyl)-D-homocysteine ( 18 F-d-FPHCys) [67] and 89 Zirconium-labeled antibody ( 89 ZrDFO-Ab) [68]. The majority of the radio-labeled amino acid tracers targets system L transporters, which includes derivatives of natural amino acids, L-phenylalanine and L-tyrosine [69].…”

Effects of Intratumoral Inflammatory Process on 18F-FDG Uptake: Pathologic and Comparative Study with 18F-Fluoro-α-Methyltyrosine PET/CT in Oral Squamous Cell Carcinoma

“…To address this, the amino acid-based PET radiotracer 18 F-fluoro-a-methyltyrosine ( 18 F-FAMT), which accumulates exclusively in malignant tumor cells through the L-type amino acid transporter 1, was developed (10)(11)(12). In previous OSCC studies, 18 F-FAMT was better than 18 F-FDG in its correlation with tumor proliferation activity, represented by Ki-67 labeling index (Ki-67 LI) (13,14).…”