Diagnostic usefulness of pregnancy-associated plasma protein-A in suspected pulmonary embolism

Berk, Serdar; Doǧan, Ömer Tamer; Aydemir, Eylem Itır; Bingöl, Aslı; Özşahin, Sefa Levent; Akkurt, İbrahim

doi:10.4081/mrm.2013.548

Cited by 2 publications

(4 citation statements)

References 7 publications

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“…-A) belongs to the metalloproteinase family. PAPP-A is synthesized by the placenta during pregnancy; therefore, it is widely used as a marker for prenatal genetic screening [27]. Moreover, PAPP-A is produced by the colon, kidneys, endometrium, bones, and testicles, among other organs [28].…”

Section: Oxidative Stress In Osamentioning

confidence: 99%

Oxidative Stress Markers among Obstructive Sleep Apnea Patients

Stanek

Brożyna-Tkaczyk

Myśliński

2021

Oxidative Medicine and Cellular Longevity

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Obstructive sleep apnea (OSA) is a chronic respiratory disorder, which can be present in up to 50% of the population, depending on the country. OSA is characterized by recurrent episodes of partial or complete obstruction of the upper airways with consistent movement of the respiratory musculature during sleep. Apneas and hypopneas can lead to a decrease in oxygen saturation, an increase in carbon dioxide in the blood, and subsequent arousals and sleep fragmentation caused by repetitive activation of the central nervous system. As a consequence, intermittent hypoxemia and consequent reoxygenation result in the production of reactive oxygen species, leading to systematic oxidative stress, which is postulated to be a key mechanism of endothelial dysfunction and increased risk for cardiovascular disorders in patients with OSA. In this review, various biomarkers of oxidative stress, including high-sensitivity C-reactive protein, pregnancy-associated plasma protein-A, superoxide dismutase, cell-free DNA, 8-hydroxy-2-deoxyguanosine, advanced oxidation protein products, lipid peroxidation products, receptor for advanced glycation end-products, and thioredoxin are discussed. Biomarkers of oxidative stress have the potential to be used to assess disease severity and treatment response. Continuous positive airway pressure (CPAP) is one of the most common noninvasive treatments for OSA; it keeps the upper airways open during sleep. This reduces episodes of intermittent hypoxia, reoxygenation, and arousal at night. CPAP has been shown to have anti-inflammatory properties and decrease oxidative stress. The administration of certain compounds, like vitamins A, C, and E as well as N-acetylcysteine and allopurinol, can decrease oxidative stress markers. However, their role in the treatment of OSA remains unclear.

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Section: Oxidative Stress In Osamentioning

confidence: 99%

Oxidative Stress Markers among Obstructive Sleep Apnea Patients

Stanek

Brożyna-Tkaczyk

Myśliński

2021

Oxidative Medicine and Cellular Longevity

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“…Fialova et al found a positive correlation between PAPP-A and CRP levels in patients who underwent dialysis [ 30 ]. In patients diagnosed with pulmonary embolism, it was reported that there were no correlations between the PAPP-A levels and inflammatory markers [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…PAPP-A is first synthesized by placenta trophoblasts during pregnancy. It is used for Down Syndrome screening in pregnancy [ 16 ]. In addition to trophoblasts, PAPP-A is reported to be synthesized in endometrium, testicle, kidney, bone, colon and other adult and fetal tissues [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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The Relation between Pregnancy-Associated Plasma Protein A and Obstructive Sleep Apnea Syndrome

Cengiz¹,

Konuk

Tuğ

2018

Canadian Respiratory Journal

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Aim We aimed to investigate the relationship between serum pregnancy-associated plasma protein A (PAPP-A) levels and obstructive sleep apnea syndrome (OSAS). Materials and Method 44 patients with OSAS and 44 healthy adults were included in this study. The participants having rheumatic or systemic inflammatory disease, advanced liver or kidney failure, diabetes, heart failure, hypertension, pregnancy, prerenal azotemia, known history of coronary artery disease, any pulmonary disease, rhinitis, or atopy, history of major trauma or surgery within the last six 6 months, and inhaled nasal or systemic corticosteroid use or other anti-inflammatory medications and those with <18 years of age were excluded. Serum PAPP-A levels were determined by the Elisa method with the immune sandwich measuring method. Statistical analysis of the study was performed with SPSS 17.0 statistical analysis package program, and p < 0.05 was considered as significant. Results Serum PAPP-A levels of patients with OSAS (2.350 ng/ml (0.641–4.796)) were significantly higher (p < 0.001) when compared with healthy controls (0.971 ng/ml (0.109–2.679)). There was a statistically significant difference in serum PAPP-A levels between groups of OSAS patients according to the classification of OSAS severity. Between the groups of patients with OSAS, serum levels of PAPP-A in moderate group was significantly higher when compared with severe OSAS group (p < 0.001). There was positive correlations between PAPP-A levels and night minimum (p=0.042, r=0.309), and average oxygen levels (p=0.006, r=0.407). There was a negative correlation between PAPP-A levels and AHI (p=0.002, r=−0.460). Conclusion Higher PAPP-A levels in OSAS patients that were found in this study show inflammatory component in OSAS.

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Diagnostic usefulness of pregnancy-associated plasma protein-A in suspected pulmonary embolism

Cited by 2 publications

References 7 publications

Oxidative Stress Markers among Obstructive Sleep Apnea Patients

Oxidative Stress Markers among Obstructive Sleep Apnea Patients

The Relation between Pregnancy-Associated Plasma Protein A and Obstructive Sleep Apnea Syndrome

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