Diagnostic utility of biomarkers in diagnosis of early stages of neonatal sepsis in neonatal intensive care unit in Egypt

El-Sonbaty, Marwa M.; Alsharany, Walaa; Youness, Eman R.; Mohamed, Nadia A.; Abdel-Hamid, Tamer A.; Abdel-Razek, A. S.

doi:10.1016/j.epag.2016.01.002

Cited by 10 publications

(10 citation statements)

References 26 publications

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“…Serial measurements improve it sensitivity and are useful for assessing the response to medical therapy [26] . Results of the present work also in line with Pessar [27] and El-Sonbaty et al [28] .…”

Section: Discussionsupporting

confidence: 92%

Impact of serum level of vitamin D on term neonates with early onset sepsis

Soliman

Sakr

Emran

et al. 2019

International Journal of Medical Arts

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Background: Neonatal sepsis a major health challenge associated with major morbidity and mortality. Neonatal care improved recently. However, different challenges regarding management still exist. Vitamin D deficiencies was proposed as a predictor of neonatal sepsis. Objective: To highlight the impact of vitamin D levels on early onset sepsis in full term neonates. Methodology: This is a case control which carried out at the neonatal intensive care unit of Al-Azhar university hospital (Damietta), from March to April 2019. It included 50 full-term neonates with probable sepsis and 50 healthy controls of matched age and sex with no signs of sepsis. Results: vitamin D level showed significant negative correlation with sepsis, Creactive protein (CRP), positive blood cultures; and significant positive correlations with Apgar score, hemoglobin concentration and platelets count. Regression analysis revealed that, higher CRP and lower vitamin D were associated risks of neonatal sepsis in univariate analysis. Multivariable regression analysis revealed that only lower vitamin D level is the predictor for early neonatal sepsis. Conclusions: Vitamin D levels were significantly lower in septic neonates with high sensitivity and specificity. Vitamin D supplementation to mothers during pregnancy could prevent early onset neonatal sepsis.

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Section: Discussionsupporting

confidence: 92%

Impact of serum level of vitamin D on term neonates with early onset sepsis

Soliman

Sakr

Emran

et al. 2019

International Journal of Medical Arts

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“…Previous studies have shown IL-6 to be a useful marker of early infection in the newborn. In our study, the serum IL-6 levels were significantly increased in newborns with sepsis compared with control in agreement with the study by Marwa El-Sonbaty et al (2016). Another study by Magudumana MO et al (2000) showed that septic preterm newborns had significantly elevated IL-6 levels at the onset of sepsis as compared to the recovery period and the controls.…”

Section: Resultssupporting

confidence: 92%

Diagnostic Markers for Early Detection of Neonatal Sepsis

Shoukry

Mohamed

Sharaf

et al. 2021

JSRMBS

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Background: Neonatal sepsis (NS) is a major health problem throughout the world. The diagnosis of sepsis is challenging due to the non-specific nature of the clinical presentation, the variety of other neonatal disorders with the differential diagnostic workup, lack of sensitivity and specificity of available diagnostic procedures, and the delay in the results of blood cultures in addition to high negative results reported. The diagnosis of suspected sepsis has to be based on clinical symptoms together with biochemical parameters. A diagnostic marker with high diagnostic sensitivity and specificity would be a valuable tool for decreasing the burden of neonatal sepsis Purpose: Evaluate the validity of interleukin-6 (IL-6) in the early diagnosis of neonatal sepsis or the use of a combination of diagnostic markers, C-reactive protein (CRP), and IL-6. Methods: The study included 30 patients with NS (Group I) and 30 healthy newborns as control (Group II) were admitted to Neonatal Intensive Care Unit (NICU) from January 2017 to June 2017. All neonates were subjected to history taking, clinical examination, and laboratory investigations including complete blood count (CBC), blood culture and sensitivity testing, CRP, and IL-6. Results: the most causative organism of neonatal sepsis in NICU was Klebsiella spp. followed by CONS. IL-6 results with cut-off value 50pg/ml, the sensitivity was 100%, the specificity was 90.32%, the positive predictive value of 90.63%, negative predictive value, and the diagnostic accuracy was 95.16. Moreover, IL-6 levels are significantly higher statistically in NS patients than controls. Conclusion: This study validated the diagnostic capability of IL-6 and showed that the combination of CRP and IL-6 as a panel for the early diagnosis of NS could enhance the sensitivity in the diagnosis of NS and may provide a new diagnostic strategy for NS patients Objective: Evaluate the validity of interleukin-6 (IL-6) in early diagnosis of neonatal sepsis or the use of combination of diagnostic markers, C-reactive protein (CRP) and IL-6. Patients and methods: The study included 30 patients with NS (Group I) and 30 apparently healthy newborns as control (Group II) were admitted to Neonatal Intensive Care Unit (NICU) from January 2017 to June 2017. All neonates were subjected to history taking, clinical examination, and laboratory investigations including: complete blood count (CBC), blood culture and sensitivity testing, CRP, and IL-6. Results: the most causative organism of neonatal sepsis in NICU was klebsiella spp. followed by CONS. IL-6 results with cut-off value 50pg/ml, the sensitivity was 100%, the specificity was 90.32%, positive predictive value of 90.63%, negative predictive value, and the diagnostic accuracy was 95.16. Moreover, IL-6 levels are significant higher statistically in NS patients than controls. Conclusion: This study validated the diagnostic capability of IL-6 and showed that the combination of CRP and IL-6 as a panel for the early diagnosis of NS could enhance the sensitivity in the diagnosis of NS and may provide a new diagnostic strategy for NS patients.

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“…6 Even though blood culture is gold standard test for diagnosing sepsis, the procedure is expensive, time consuming as it takes 48-72 hours, has low yield due to insufficient sample volumes, intermittent or low-density bacteraemia, or suppression of bacterial growth by earlier (i.e., intrapartum) antibiotic administration. [17][18][19] Moreover the technique demands a well-equipped laboratory which is not available in most of the community hospitals. [20][21][22] In the recent past, various markers which are both sensitive and specific like ELISA methods, prolactins, haptoglobins, interleukins, molecular analysis by polymerase chain reaction (PCR) for bacterial DNA etc.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic utility of haematological parameters and C-reactive protein in early detection of neonatal septicaemia in developing countries

2020

IJPO

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Introduction: Septicaemia is one of the major causes of mortality and morbidity during the neonatal period especially in developing countries. Early diagnosis of neonatal sepsis is a diagnostic problem due to non-specific clinical features. Blood culture is the gold standard, but it takes several days and is expensive. Hence there is a critical need for laboratory tests that aid in the rapid diagnosis of neonatal sepsis. Aims and Objectives: To measure the role of Haematological Scoring System and C-reactive protein as an early diagnostic tool for neonatal sepsis. Materials and Methods:This was a prospective study performed on 116 neonates, who were clinically suspected cases of septicaemia, admitted at Neonatal Intensive Care Unit, Yenepoya Hospital, Mangalore. Each hematologic parameter like total leukocyte count, polymorphonuclear neutrophil (PMN) count, immature PMN count, platelet count etc. were analysed in all cases using the Haematological Scoring System (HSS) formulated by Rodwell et al. Blood cultures were performed as a gold standard. C-reactive protein (CRP) was also estimated. Results: Out of 116 neonates, 61(52%) were male neonates and 55(48%) were female neonates. 18(15%) cases were with proven sepsis, 58(50%) cases with probable sepsis and 40(35%) cases were on the safer side. The HSS was found to have a sensitivity of 94.4%, specificity of 75.5%, positive predictive value was 41.4% and negative predictive value was 98.6%. Conclusions: HSS is a rapid, simple and easily affordable screening tool for early detection of neonatal septicaemia. It also provides an effective guideline to make decisions regarding judicious use of antibiotics.

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Diagnostic utility of biomarkers in diagnosis of early stages of neonatal sepsis in neonatal intensive care unit in Egypt

Cited by 10 publications

References 26 publications

Impact of serum level of vitamin D on term neonates with early onset sepsis

Impact of serum level of vitamin D on term neonates with early onset sepsis

Diagnostic Markers for Early Detection of Neonatal Sepsis

Diagnostic utility of haematological parameters and C-reactive protein in early detection of neonatal septicaemia in developing countries

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