Diagnostic utility of gene X-pert in the diagnosis of tuberculous pleural effusion

El-Din, Magd Galal; Sobh, Eman; Adawy, Zeinab; Farghaly, Naira

doi:10.1080/23744235.2018.1532105

Cited by 8 publications

(3 citation statements)

References 9 publications

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“…Pleural fluid/biopsy mycobacterial culture and pleural biopsy histopathology, on the other hand, have higher sensitivity (>80%) for the diagnosis of tuberculous pleural effusion. 11 While, in Mona Mansour et al, study 63 of 71 cases were positive for TB pleurisy with respect to the gold standard histopathology report, but the GeneXpert identified positive results in only 16 of 71 cases. The Gene Xpert had higher specificity performance (75%), whereas its sensitivity power was lower (22.2%).…”

Section: Discussionmentioning

confidence: 94%

Evaluation of Gene Xpert versus Pleural Biopsy in Diagnosis of Suspected Cases of Tuberculous Pleural Effusion.

Al-Sokromi¹,

Sabaa²,

Halema³

et al. 2022

Al-Azhar International Medical Journal

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Section: Discussionmentioning

confidence: 94%

Evaluation of Gene Xpert versus Pleural Biopsy in Diagnosis of Suspected Cases of Tuberculous Pleural Effusion.

Al-Sokromi¹,

Sabaa²,

Halema³

et al. 2022

Al-Azhar International Medical Journal

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“…Finally, 18 articles were included for meta‐analysis. 5 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 …”

Section: Resultsmentioning

confidence: 99%

Accuracy of Xpert MTB/RIF assay for the diagnosis of tuberculous pleural effusion

Qiu

Chen

et al. 2021

Clinical Laboratory Analysis

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Background Tuberculosis poses a severe threat to human health. At present, compared with the traditional diagnostic methods for tuberculosis pleural effusion, such as Löwenstein–Jensen culture, pleural biopsy, and Ziehl–Neelsen smear microscopy, Xpert MTB/RIF was regarded as an emerging technology for its efficiency. The Xpert MTB/RIF accuracy for tuberculous pleural effusion diagnosis was evaluated in this systematic study. Materials and methods We searched the relevant literature published before January 2021 in PubMed, Cochrane, EMBASE, and Web of Science databases. Utilizing Review Manager 5.3 software, the quality of the included literature was evaluated based on the Quality Assessment of Diagnostic Accuracy Studies criteria. Sensitivity, specificity, and the summary receiver operating characteristic curves were plotted and analyzed with Metadisc 1.40 software. We used Stata 12.0 software to evaluate the publication bias of this study. Results Eighteen articles were identified in total. The sensitivity of Xpert MTB/RIF in the pleural effusion was 0.24, and specificity was 1.00, respectively. The area under the summary receiver operating characteristic curve was 0.9737, which indicated that the overall accuracy of the Xpert MTB/RIF was high. In addition, based on the Deeks funnel plot, no publication bias of the study was found. Conclusion Xpert MTB/RIF is a rapid method with high specificity but relatively low sensitivity for detecting Mycobacterium tuberculosis in pleural effusion. Its less sensitivity made it difficult to be used clinically, but the high specificity suggests that it can be used as a specific diagnostic method for tuberculous pleural effusion.

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“…As reported in a previous study, pleural involvement was ranked as the second site affected by TB among childhood TB 3 . Due to the paucibacillary nature of pleural samples, or the disease, the diagnosis of childhood pleural TB remains a difficulty to be defined 4 . Hence, the diagnostic or treatment delay easily occurs and a poor outcome may be then produced.…”

mentioning

confidence: 99%

Risk factors associated with surgical intervention in childhood pleural tuberculosis

Zhou

Gong

Wang

2021

Sci Rep

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Surgical intervention use is common in the management of childhood pleural tuberculosis (TB), however, its associated risk factors remain unclear. Between January 2006 and December 2019, consecutive children patients (≤ 15 years old) who had a diagnosis of pleural TB were included for the analysis. Surgical intervention was defined as debridement (such as breaking loculations), decortication, and thoracic surgery (such as lobectomy or segmental resection). Patients undergoing surgery were included as surgical group, without surgery were classified as non-surgical group, surgical risk factors were then estimated. Univariate and multivariate logistic regression analysis were performed to evaluate the risk factors for surgical interventions. A total of 154 children diagnosed as pleural TB (definite, 123 cases; possible, 31 cases) were included in our study. Of them, 29 patients (18.8%) were classified as surgical group and 125 patients (81.2%) were classified as non-surgical group. Surgical treatments were analyzed in 29 (18.8%) patients, including debridement (n = 4), decortication (n = 21), and thoracic surgery (n = 4). Further multivariate analysis revealed that empyema (age- and sex-adjusted OR = 27.3, 95% CI 8.6, 87.1; P < 0.001) and frequency of hospitalization (age- and sex-adjusted OR = 1.53, 95% CI 1.11, 2.11; P < 0.01) were associated with the use of surgical interventions in children with pleural TB. In China, surgical interventions are still required in a significant proportion of children with pleural TB, and the surgical risk is found to be associated with the frequency of hospitalization and empyema. These findings may be helpful to improve the management of children with pleural TB and minimize the risk of poor outcomes.

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Diagnostic utility of gene X-pert in the diagnosis of tuberculous pleural effusion

Cited by 8 publications

References 9 publications

Evaluation of Gene Xpert versus Pleural Biopsy in Diagnosis of Suspected Cases of Tuberculous Pleural Effusion.

Evaluation of Gene Xpert versus Pleural Biopsy in Diagnosis of Suspected Cases of Tuberculous Pleural Effusion.

Accuracy of Xpert MTB/RIF assay for the diagnosis of tuberculous pleural effusion

Risk factors associated with surgical intervention in childhood pleural tuberculosis

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