Diagnostic Utility of PET CT in Thymic Tumours with Emphasis on 68Ga-DOTATATE PET CT in Thymic Neuroendocrine Tumour - Experience at a Tertiary Level Hospital in India

Hephzibah, Julie; Shanthly, Nylla; Oommen, Regi

doi:10.7860/jcdr/2014/10499.4840

Cited by 16 publications

(15 citation statements)

References 10 publications

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“…The absence of thymic carcinomas in our surgically resected cases may be because these cases present at an advanced stage of the disease when surgical resection may not be a treatment option. Global data have reported no sex predilection for TETs; however, the Indian studies had shown male predominance similar to the observation in the present series101415171823. Only two studies from India demonstrated a female-predominant population1316.…”

Section: Discussionsupporting

confidence: 82%

“…Its incidence in the Indian population has not been defined and in the power analysis carried out by Marchevsky et al 11, only 20 cases of thymomas were included from India. Among the Indian studies with more than 10 cases121314151617181920, Julka et al 18 had the largest sample with 71 cases (all thymomas) from the same centre; however, histomorphological spectrum was not described in this study. Except for studies by Vaideeswar et al 19 and Sundaram et al 20, none of the studies assessed the histomorphology of TET, especially thymic carcinomas.…”

Section: Discussionmentioning

confidence: 68%

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Histotyping of Indian thymomas

Guleria

Parshad

Malik

et al. 2019

Indian Journal of Medical Research

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Background & objectives:Thymomas are rare, but most common anterior mediastinal lesions. The histomorphologic spectrum of thymic epithelial tumours (TETs) in Indian population has not been explored in depth. This study was aimed to assess the histomorphology of TETs in the Indian patients and correlate clinical parameters with pathological features.Methods:It was a retrospective study conducted in a tertiary referral hospital in north India. All morphologically confirmed cases of TETs since 2009 were included. Clinical details and histology slides were reviewed using the Modified Masaoka-Koga staging system and WHO 2015 classification. Clinicopathological correlation and survival analysis were done. A comparative review from other published Indian studies was performed.Results:A total of 219 cases of TETs (138 resections and 81 biopsies) were identified. The most common histomorphologic type was B2, and the most frequent stage was I. Types A/AB were common in older age (P<0.01). Clinically, higher stage tumours were found mostly in men (P<0.01), and these were Type B thymomas (P<0.01). Myasthenia gravis was more common in women (P<0.02) and in lower stages (P<0.05). Survival analysis revealed significant association between recurrence and tumour stage. Although thymic carcinoma was diagnosed on biopsy, no resectable case was identified.Interpretation & conclusions:Our findings showed that the thymomas in Indian patients were most commonly Stage I tumours of B2 and AB histotypes. Resected thymic carcinomas were conspicuously absent in our study. More studies need to be done to establish the frequency and biology of TETs from India.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 68%

Histotyping of Indian thymomas

Guleria

Parshad

Malik

et al. 2019

Indian Journal of Medical Research

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“…Approximately 40% of the encountered individuals would have lymphadenopathy present on the initial encounter as it was seen with our patient 5. Hephzibah et al and Sung et al reported regarding the importance of PET–CT in the evaluation of thymic tumours for initial workup, treatment response, prognosis and aid in distinguishing thymoma from thymic carcinoma 6 7…”

Section: Discussionmentioning

confidence: 57%

A bimodal approach to thymic carcinoma with pericardial sac invasion

Ahmed

Soin²,

Patel

2019

BMJ Case Rep

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Thymic carcinoma is a rare tumour of the thymus, representing less than 1% of thymic malignancies. 1 It has an annual incidence of 0.15–0.32 per 1 00 000 person-years. 2 It is found incidentally in 30% of the patients as an opacity on chest X-ray or with non-specific complaints of persistent cough, chest pain, fatigue, shortness of breath, arm and facial swelling, and upper airway congestion related to tumour extension. We present the case of a 59-year-old man with a history of Graves’ disease status post radiation treatment presenting with cough and left lingual opacity on chest X-ray, confirmed to be thymic carcinoma with pericardial invasion and lymph node metastasis. We aim to discuss the presentation, treatment modalities and outcome associated with this rare tumour.

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“…görülebilen bu lezyonlar bronşial karsinoidlere zıt olarak genellikle FDG avid olup FDG PET-BT ile primer lezyonların, metastazların ve rekürrenslerin tesbiti mümkündür (88). Galyum 68 ile işaretli peptidlerin kullanılarak somatostatin reseptörlerinin görüntülenmesi ile de rekürrenslerin ve metastazların tesbit edilebileceği bildirilmiştir (89,90).…”

Section: Ti̇mi̇k Tümörlerunclassified

Pet Applications For Staging And Restaging In Thoracic Malignancies

Öneş¹,

Erdıl²

2015

Toraks Cer Bult

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In the last 10 years, Fluorine-18 fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) scan has been widely adopted in thoracic oncology, showing high accuracy in staging and restaging. The aim of this review was to focus on the results of PET scan use in the evaluation of thoracic malignancies. The literature search was performed on January 2015 in PubMed and Google Academic. The search was restricted to publications in English, using in the same string the word "PET" with different thoracic tumors. From 3000 papers initially selected, the irrelavant articles eliminated and then approximately 100 manuscripts were fully analyzed. In conclusion, positron emmision tomography/ computed tomography (PET-CT) has established itself as an important step in the evaluation of patients with thoracic malignancies. Further evaluation and come into use of newer PET tracers and simultaneous Magnetic Resonance Imaging (MRI) with PET (PET/MR) imaging will offer additional options in thoracic oncology in future.

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Diagnostic Utility of PET CT in Thymic Tumours with Emphasis on 68Ga-DOTATATE PET CT in Thymic Neuroendocrine Tumour - Experience at a Tertiary Level Hospital in India

Cited by 16 publications

References 10 publications

Histotyping of Indian thymomas

Histotyping of Indian thymomas

A bimodal approach to thymic carcinoma with pericardial sac invasion

Pet Applications For Staging And Restaging In Thoracic Malignancies

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