Diagnostic Utility of Polymerase Chain Reaction for Paraffin-embedded Sinus Specimens for Rhinocerebral Mucormycosis Complicated by Internal Carotid Artery Thrombosis and Cerebral Infarction

Maeda, Yukiko; Toda, Kunio; Toi, Sono; Yano, Tetsundo; Iijima, Makoto; Shimizu, Yuko; Nagashima, Yoji; Itakura, Yasutomo; Iguchi, Shigekazu; Kikuchi, Ken; Shibuya, Kazutoshi; Nonaka, Manabu; Kitagawa, Kazuo

doi:10.2169/internalmedicine.6809-20

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Revannavar et al 4 reported acute infarct in left parieto-occipital lobe in a patient with uncontrolled diabetes and rhino-orbital involvement. Maeda et al 5 reported acute ischemic stroke with internal carotid artery occlusion and invading mucormycosis into cavernous sinus. Krishna et al 6 described acute anterior cerebral artery infarct in a patient with severe COVID and autopsy proven disseminated mucormycosis.…”

Section: Resultsmentioning

confidence: 99%

Mucormycosis Epidemic and Stroke in India During the COVID-19 Pandemic

Srivastava

Vishnu

Pandit

2021

Stroke

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he coronavirus disease 2019 (COVID-19) pandemic ravaged India over the last 18 months, particularly in the second wave (March-June 2021). During this period, India reported 29 977 61 confirmed cases of COVID-19 with 389 302 deaths. 1 India also witnessed an unexpected epidemic of fungal infection, mucormycosis, in the second wave. As of June 7, 2021, 28 000 cases of mucormycosis were reported from India. 2 METHODSWe performed systematic search using keywords "Mucormycosis, " "COVID19, " and "stroke" in the Pubmed, MEDLINE, EMBASE, Google Scholar, Cochrane, and Scopus databases till June 7, 2021. Personal communications of unpublished and ongoing studies were also included. The authors declare that all supporting data are available within the article.

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Section: Resultsmentioning

confidence: 99%

Mucormycosis Epidemic and Stroke in India During the COVID-19 Pandemic

Srivastava

Vishnu

Pandit

2021

Stroke

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“…Computed tomography, or magnetic resonance imaging, is a commonly used diagnostic method. ROCM can also be diagnosed by molecular detection, species identification, polymerase chain reaction 11 and other methods in addition to the gold criteria of diagnosis-histopathological examination and fungal culture. 12 The incidence of ROCM is increasing worldwide.…”

Section: Discussionmentioning

confidence: 99%

A case report on clinical features, diagnosis, and treatment of rhino‐orbito‐cerebral mucormycosis

Ding,

Xie

2023

Immunity Inflam & Disease

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BackgroundRhino‐orbito‐cerebral mucormycosis (ROCM) is an opportunistic pathogenic fungal disease caused by the fungus mucor, and it is a life‐threatening fungal infection. The ulceration on the skin of the head and neck, accompanied by rhinitis, headache, orbital inflammation, and eyelid edema, should raise a high suspicion of Mucor infection in diabetic patients with inadequately controlled blood glucose.Case DescriptionThe clinical data of a patient with ROCM were analyzed retrospectively, and the clinical features were analyzed. The patient was admitted to the hospital with “diabetic hyperosmotic coma” after presenting with fatigue, poor appetite, and disturbances in consciousness as initial symptoms. After improving relevant examinations, controlling underlying diseases, and administering antifungal treatment, the final clinical outcome was death.ConclusionROCM is more prevalent in patients with uncontrolled diabetes and varied clinical manifestations. The characteristic feature is an eschar‐like necrosis of the local skin or mucosa. The gold criteria for diagnosis are pathology and fungal culture; imaging examination does not reveal any specific manifestations. Early diagnosis and effective treatment are the keys.

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上顎骨壊死を契機に発見された鼻脳型ムコール症の1例

NAKAMURA,

SATO,

KATO

et al. 2023

Jpn. J. Oral. Maxillofac. Surg.

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R hinocerebral mucormycosis generally occurs in immunosuppressive conditions such as uncontrolled diabetes mellitus and steroid therapy, and presents acute and aggressive clinical symptoms. Therapeutic strategies for rhinocerebral mucormycosis consist of control of the original immunosuppressive disease, surgery and medication. The prognosis of this condition depends on early diagnosis and treatment. Rhinocerebral mucormycosis rarely presents initial symptoms in the oral cavity. We experienced a case in which rhinocerebral mucormycosis was detected via maxillary osteonecrosis. We played a central role in providing treatment and saving the patient' s life, and his quality of life (QOL) was maintained. The patient was a 62-year-old man who visited our department with severe pain in the left upper molar region. His medical history included rectal cancer with metastatic lung cancer, type 2 diabetes, and coronary spastic angina. Gingival necrosis and sequestrums were observed in the left upper molar region seven days after his first visit. The diagnosis of mucormycosis was made based on micro-fungal biological and pathological samples. Following discussion with related clinical departments, we performed oral surgery twice and a physician provided medication via an antifungal drug. The patient recovered well following treatment. He has returned to work and has been maintaining his QOL over two years under routine follow-up.

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Diagnostic Utility of Polymerase Chain Reaction for Paraffin-embedded Sinus Specimens for Rhinocerebral Mucormycosis Complicated by Internal Carotid Artery Thrombosis and Cerebral Infarction

Cited by 3 publications

References 11 publications

Mucormycosis Epidemic and Stroke in India During the COVID-19 Pandemic

Mucormycosis Epidemic and Stroke in India During the COVID-19 Pandemic

A case report on clinical features, diagnosis, and treatment of rhino‐orbito‐cerebral mucormycosis

上顎骨壊死を契機に発見された鼻脳型ムコール症の1例

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