Diagnostic value of 18F-FDG-PET/CT for the evaluation of solitary pulmonary nodules

Abstract

The results of our analysis suggest that PET/CT is a useful tool for detecting malignant pulmonary nodules qualitatively. Although current evidence showed moderate accuracy for PET/CT in differentiating malignant from benign solitary pulmonary nodules, further work needs to be carried out to improve its reliability.

MRI for solitary pulmonary nodule and mass assessment: Current state of the art

“…A meta-analysis reported that the pooled diagnostic yield of transthoracic needle aspiration biopsy (TTAB) guided by electromagnetic navigation bronchoscopy, virtual bronchoscopy, or radial endobronchial ultrasound was 70%. [32][33][34][35][36][37][38] In contrast to CT, PET, and PET/CT, MRI has been tested to demonstrate its clinical relevance for diagnosis of pulmonary nodules by means of various noncontrastenhanced MRI techniques. 28 Therefore, it may be considered that the diagnostic performance of either of these radiological examinations is better than that of TTAB, and that the diagnostic yield of the latter should be as close as possible to that of CT-guided PNAB or PCNB when used in routine clinical practice.…”

“…However, FDG-PET and FDG-PET/CT began to be advocated in the 1990s and it was suggested that it was more useful than CT, and came to be frequently applied in routine clinical practice in the 2000s because FDG-PET and FDG-PET/CT provide glucose metabolism-based information within pulmonary nodules and masses. [32][33][34][35][36][37][38] In contrast to CT, PET, and PET/CT, MRI has been tested to demonstrate its clinical relevance for diagnosis of pulmonary nodules by means of various noncontrastenhanced MRI techniques. These include conventional T 1and T 2 -weighted imaging, STIR turbo SE imaging and DWI, nondynamic and dynamic contrast-enhanced MRI, as well as molecular MRI techniques that have recently come into use, such as chemical exchange saturation transfer (CEST) imaging.…”

Diagnostic Performance of PET or PET/CT with Different Radiotracers in Patients with Suspicious Lung Cancer or Pleural Tumours according to Published Meta-Analyses

“…From the comprehensive computer literature search from PubMed/MEDLINE and Cochrane Library databases, 17 meta-analyses were selected and retrieved in full-text version [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. e characteristics of the selected articles are summarized and presented in Table 1 and summarized as follows.…”

“…Characterizing SPNs detected incidentally or, as is the case more recently, on CT screening for LC, is a major public health issue. In the last decade, a robust evidence has been produced on the use of single time point (STP) 18 F-FDG PET or PET/CT in the characterization of SPNs [5][6][7][8][9][10][11]. Two examples of 18 F-FDG PET/CT images in the characterization of SPNs are shown in Figure 1.…”

Comprehensive targeted super-deep next generation sequencing enhances differential diagnosis of solitary pulmonary nodules

“…Non-invasive tests are preferable. 18 F-FDG-PET/CT only slightly adds to diagnostic value, and its use is limited by its low cost-effectiveness (8). A few plasma biomarkers, such as CEA and CA-125, have been used to screen and diagnose lung cancers (9)(10)(11).…”