Diagnostic value of 3D-FLAIR magnetic resonance sequence in detection of white matter brain lesions in multiple sclerosis

Tawfik, Ahmed Ibrahim; Kamr, Wael Hamza

doi:10.1186/s43055-020-00247-6

Cited by 16 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3D FLAIR sequence showed significantly more lesions than 2D FLAIR, that in keeping with Gramsch et al, [13] that state that adding 3D FLAIR sequence in standard MS protocols can considerably increase MS lesion detection and provide the possibility of an adequate replacement of both axial 2D FLAIR and mid-sagittal T2W sequences. This results also matched with Tawfik et al, [14] and Patzig et al, [12] who used 3 Tesla MRI machine.…”

Section: Discussionsupporting

confidence: 89%

Diagnostic value of three-dimensional cube fluid attenuated inversion recovery imaging and its axial MIP reconstruction in multiple sclerosis

Zamzam

Khadrah

Khali

et al. 2022

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

Background Magnetic resonance imaging is regarded as one of the most important markers for multiple sclerosis. It can detect lesions in order to establish dissemination in time and space, which would aid in the diagnosis. Two-dimensional FLAIR is a standard sequence in MS routine imaging because it suppresses cerebrospinal fluid signal, increasing contrast between lesions and CSF and improving white matter lesion detection. Newer 3D FLAIR sequences are expected to offer even more benefits, such as improved MS lesions detection and higher resolution due to thinner slice thickness. We aimed to compare the role of 3D Cube FLAIR imaging (versus standard 2D FLAIR) in the assessment of white matter lesions in MS patients, as well as to test the convenience of using maximum intensity projection (MIP) on 3D FLAIR images for faster and easier evaluation. Results This study included 160 MS patients. A 1.5 T routine brain MRI scan was performed, which included a 2D FLAIR sequence, followed by a 3D-FLAIR sequence. All images were analyzed after 3D-FLAIR images were reformatted into axial MIP images. Lesions were counted in each sequence and classified into supra-tentorial (periventricular, deep white matter, and juxta-cortical), and infra-tentorial lesions, with the relative comparison of lesions numbers on 3D-FLAIR and MIP versus 2D-FLAIR expressed as a percentage increase or decrease. 3D FLAIR can significantly improve MS lesion detection in all areas of the brain when compared with 2D FLAIR results. At 2 mm reformatting, there is no difference in MS lesion detection between sagittal 3D FLAIR and axial MIP reconstruction, implying that the MIP algorithm can be used to simplify lesion detection by reducing the number of images while maintaining the same level of reliability. Conclusion 3D FLAIR sequences should be added to conventional 2D FLAIR sequences in the MRI protocol when MS is suspected.

show abstract

Section: Discussionsupporting

confidence: 89%

Diagnostic value of three-dimensional cube fluid attenuated inversion recovery imaging and its axial MIP reconstruction in multiple sclerosis

Zamzam

Khadrah

Khali

et al. 2022

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

show abstract

“…Limitations still exist, however, as some authors have shown that T2/FLAIR WMHs overestimate neuropathologically confirmed demyelination in the periventricular areas but underestimate it in the deep WM [ 45 ], and overall sensibility and specificity hovers around 80% to 90%. As with all MRI measurements, higher field strengths and resolutions (3D versus 2D) will produce better results [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Predictive MRI Biomarkers in MS—A Critical Review

et al. 2022

View full text Add to dashboard Cite

Background and Objectives: In this critical review, we explore the potential use of MRI measurements as prognostic biomarkers in multiple sclerosis (MS) patients, for both conventional measurements and more novel techniques such as magnetization transfer, diffusion tensor, and proton spectroscopy MRI. Materials and Methods: All authors individually and comprehensively reviewed each of the aspects listed below in PubMed, Medline, and Google Scholar. Results: There are numerous MRI metrics that have been proven by clinical studies to hold important prognostic value for MS patients, most of which can be readily obtained from standard 1.5T MRI scans. Conclusions: While some of these parameters have passed the test of time and seem to be associated with a reliable predictive power, some are still better interpreted with caution. We hope this will serve as a reminder of how vast a resource we have on our hands in this versatile tool—it is up to us to make use of it.

show abstract

“…The main reason for this tendency might be that 3D images take more time to complete compared with 2D images, which may present an issue when treating a large number of patients and processing long waiting lists. However, because 3D images have a higher sensitivity for MS lesions in the periventricular region, deep white matter, juxta-cortical region, and infratentorial region [20,21], they are always recommended in MR protocol.…”

Section: Discussionmentioning

confidence: 99%

Adherence to MRI Protocol Consensus Guidelines in Multiple Sclerosis Patients at Taif Hospitals

Alamri¹

2020

IJMI

View full text Add to dashboard Cite

Background: multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system (CNS). Its diagnosis is characterized by foci of demyelination, disseminated over time and anatomical space, both clinically and radiologically. Consensus guidelines for the diagnosis of MS have been established to identify the proper sequences and imaging technique. Objective: this study aims to investigate the adherence of Taif hospitals to these consensus guidelines. Method: data were collected from the radiology departments of 3 main hospitals in Taif (King Abdul-Aziz Specialist Hospital, King Faisal Medical Complex, and Al-Hada Hospital for Armed Forces). The standard magnetic resonance imaging (MRI) protocol for MS in each hospital was reviewed using the picture archiving and communication system (PACS). The comparisons were based on the strength of the magnetic field, slice thickness, slice orientation, coverage, and the MR core sequences used. Results: each Taif hospital has its own protocol, which differ from consensus guidelines. The main difference is the hospitals' lack of 3D sequences. Another difference is the lack of inversion recovery prepared T1 sequences. Finally, for follow-up patients, no contrast administration exists in Taif hospitals. Conclusion: this study shows some major differences in the MS protocols among Taif hospitals. This is probably due to poor awareness of the guidelines in the radiology community. Neuroradiologists at Taif hospitals should ensure the recommended protocol is followed.

show abstract

Diagnostic value of 3D-FLAIR magnetic resonance sequence in detection of white matter brain lesions in multiple sclerosis

Cited by 16 publications

References 28 publications

Diagnostic value of three-dimensional cube fluid attenuated inversion recovery imaging and its axial MIP reconstruction in multiple sclerosis

Diagnostic value of three-dimensional cube fluid attenuated inversion recovery imaging and its axial MIP reconstruction in multiple sclerosis

Predictive MRI Biomarkers in MS—A Critical Review

Adherence to MRI Protocol Consensus Guidelines in Multiple Sclerosis Patients at Taif Hospitals

Contact Info

Product

Resources

About