Diagnostic value of alpha-l-fucosidase for hepatocellular carcinoma: a meta-analysis

Gan, Yuling; Liang, Qiuzhen; Song, Xinghua

doi:10.1007/s13277-013-1563-8

Cited by 45 publications

(43 citation statements)

References 30 publications

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“…Its serum levels have been shown to increase in patients with cirrhosis and HCC [45] . At a threshold of 2.3005 µmol/L per minute, AFU yielded a sensitivity and specificity of 90% and 97.5%, respectively [46] .…”

Section: Alpha-l-fucosidasementioning

confidence: 97%

Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma

Khattab

Fouad

Ahmed

2015

WJH

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The prevalence of hepatocellular carcinoma (HCC) has progressively increased in recent years and is now the fifth and the second most common cancer in the World and in Egypt, respectively. Much work has focused in the development of assays for detecting hepatic carcinogensis before the observance of hepatic focal lesions. Particular attention has been directed towards HCC-specific biomarkers for use in the early diagnosis of HCC and in the confirmation of radiological studies. Although a number of biomarkers have been identified, none have been considered reliable indicators of early HCC lesions. This review presents a few of the most relevant HCC biomarkers and suggests improvements to the accuracy of diagnostic assays through their combined use. Furthermore, we present an algorithm for the biomarker-based diagnosis of HCC and highlight its important role in the early prediction of HCC. Core tip: Alpha-fetoprotein (AFP) has been widely used as a reference biomarker to validate the diagnosis of hepatocellular carcinoma (HCC). However, normal physiological-levels of AFP are observed in approximately one third of HCC cases. Furthermore, a number of HCC positive patients have AFP levels less than the threshold value of 400 ng/mL. These factors make an AFP-based diagnosis of HCC far from reliable. However, high diagnostic accuracy indices have been reported when AFP is combined with other biomarkers such as midkine, golgi protein 73, des-γ-carboxyprothrombin, glypican-3, and gamma-glutamyl transferase.Khattab M, Fouad M, Ahmed E. Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma. World J Hepatol 2015; 7(23): 24742481 Available from:

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Section: Alpha-l-fucosidasementioning

confidence: 97%

Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma

Khattab

Fouad

Ahmed

2015

WJH

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“…In addition, the midkine can serve as a useful marker in the diagnosis of AFP-negative HCCs and at a very early stage 5. Furthermore, several diagnostic biomarkers were identified continuously, such as Dickkopf-1,6 Golgi protein 73,7 Glypican-3,8 γ-glutamyl transferase,9 α-l-fucosidase,10 transforming growth factor β-1,11 IGFs,12 squamous cell carcinoma antigen,13 osteopontin,14 heat shock proteins,15 and so on, among which most of them can be used together with AFP for diagnosis of HCC. Actually, combination of more than one biomarker may improve the accuracy of HCC diagnoses 16…”

Section: Introductionmentioning

confidence: 99%

Integrative Analysis of Microarray Data to Reveal Regulation Patterns in the Pathogenesis of Hepatocellular Carcinoma

Chen

Qian

Li³

et al. 2017

Gut and Liver

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Background/AimsThe integration of multiple profiling data and the construction of a transcriptional regulatory network may provide additional insights into the molecular mechanisms of hepatocellular carcinoma (HCC). The present study was conducted to investigate the deregulation of genes and the transcriptional regulatory network in HCC.MethodsAn integrated analysis of HCC gene expression datasets was performed in Gene Expression Omnibus. Functional annotation of the differentially expression genes (DEGs) was conducted. Furthermore, transcription factors (TFs) were identified, and a global transcriptional regulatory network was constructed.ResultsAn integrated analysis of eight eligible gene expression profiles of HCC led to 1,835 DEGs. Consistent with the fact that the cell cycle is closely related to various tumors, the functional annotation revealed that genes involved in the cell cycle were significantly enriched. A transcriptional regulatory network was constructed using the 62 TFs, which consisted of 872 TF-target interactions between 56 TFs and 672 DEGs in the context of HCC. The top 10 TFs covering the most downstream DEGs were ZNF354C, NFATC2, ARID3A, BRCA1, ZNF263, FOXD1, GATA3, FOXO3, FOXL1, and NR4A2. This network will appeal to future investigators focusing on the development of HCC.ConclusionsThe transcriptional regulatory network can provide additional information that is valuable in understanding the underlying molecular mechanism in hepatic tumorigenesis.

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“…These include, but are not limited to: DCP [37,38], Glypican-3 [39], fucosylated serum paraoxonase 1 [40] and alpha-1 acid glycoprotein [41], TEMs [42], Dickkopf-1 [43] and EpCam stained circulating tumor cells [44] and staining of HCCs [45], C-reactive protein [46], alpha-L-fucosidase [47] and hepatic miRs [48]. With such a high percent of small and large HCCs having low AFP levels, novel biomarkers are clearly needed.…”

Section: Discussionmentioning

confidence: 99%

Quantum biophysics of water

Akkız

Üsküdar

et al. 2018

clinical-practice

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A large database of 1773 HCC patients in Turkey was examined. 41.9% had alpha-fetoprotein (AFP) levels <20 IU/ml and an additional 16.123% had values between 20-100 IU/ml. This 58% of the cohort (<100 IU/ml AFP levels) was examined in detail. 66% of patients with small (<5 cm) HCCs had low AFP, compared to 49% of patients with larger (>5 cm) HCCs. The mean diameter (MTD) of larger MTD, low AFP tumors was 8.4cm. Therefore, factors other than AFP must contribute to HCC tumor growth. Larger tumors in low AFP patients had both higher platelet levels and increased PVT percent. Linear regression analysis for both MTD and multifocality showed that platelet numbers and presence of PVT were significant variables; whereas for PVT, significant variables were albumin, alkaline phosphatase and MTD. Comparisons between patients with AFP levels <20, 20-<100, 100-<1000 and >1000 IU/ml showed the most significant tumor finding was an increase in PVT percent between each group, and to a lesser extent, MTD. Thus, low-or normal-AFP HCCs constitute the majority of patients and have slightly lower MTD and much lower PVT percent than HCCs associated with elevated blood AFP levels. New, non-AFP markers are thus needed, especially for small HCCs

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Diagnostic value of alpha-l-fucosidase for hepatocellular carcinoma: a meta-analysis

Cited by 45 publications

References 30 publications

Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma

Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma

Integrative Analysis of Microarray Data to Reveal Regulation Patterns in the Pathogenesis of Hepatocellular Carcinoma

Quantum biophysics of water

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