Diagnostic value of anti-cyclic citrullinated peptide antibody combined with rheumatoid factor in rheumatoid arthritis in Asia: a meta-analysis

Abstract

Objective This meta-analysis explored the diagnostic value of anti-cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor (RF) for rheumatoid arthritis (RA) in the Asian population. Methods Embase, Medline, Cochrane Library, Chinese Science and Technology Periodicals, China National Knowledge Infrastructure, and China Wanfang Databases were searched from 1 January 2000 to 1 February 2021 to collect studies on the combined detection of anti-CCP and RF for diagnosing RA. The sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (+LR), and negative likelihood ratio (−LR) were combined and analyzed. Summary receiver operating characteristic (SROC) curves were drawn. Results Twenty-four published papers were analyzed, including 21 combined in series and 8 combined in parallel. In the tandem analysis, the sensitivity = 0.64 [95% confidence interval (CI): 0.58–0.70], specificity = 0.97 (95%CI: 0.95–0.98), +LR = 19.70 (95%CI: 12.74–30.46), −LR = 0.37 (95%CI: 0.31–0.43), DOR = 53.43 (95%CI: 34.46–82.40), and area under the SROC curve = 0.89. In the parallel combination, the sensitivity = 0.87 (95%CI: 0.80–0.92), specificity = 0.76 (95%CI: 0.67–0.84), +LR = 3.68 (95%CI: 2.62–5.17), −LR = 0.17 (95%CI: 0.11–0.26), DOR = 21.56 (95%CI: 11.63–39.99), and area under the SROC curve = 0.89. Conclusion Anti-CCP and RF combined detection improves the diagnostic efficiency of RA, providing a potential strategy for early clinical screening in the Asian population. This trial was retrospectively registered in the INPLASY/Research Registry ( https: //inplasy.com/ ) with the registration number INPLASY202180106.

Investigation of periodontitis, halitosis, xerostomia, and serological characteristics of patients with osteoarthritis and rheumatoid arthritis and identification of new biomarkers

“…In 2010, the ACR and EULAR added anti-CCP Ab, also known as ACPA, a biomarker predicting aggressive RA, to the existing biomarker, RF, and revised the classification criteria to emphasize the characteristics of early RA 49 . Recently, the detection of autoantibodies such as RF and anti-CCP Ab has provided an important basis for early diagnosis and assessment of disease activity 50 , 51 . In this study, the significant predictors of RA compared to OA were xerostomia (AUC = 0.900), anti-CCP Ab (AUC = 0.808), and RF (AUC = 0.746).…”

Investigation of periodontitis, halitosis, xerostomia, and hematological characteristics of patients with osteoarthritis and rheumatoid arthritis and identification of new biomarkers

“…In 2010, the ACR and EULAR added anti-CCP Ab, also known as ACPA, a biomarker predicting aggressive RA, to the existing biomarker, RF, and revised the classi cation criteria to emphasize the characteristics of early RA [45]. Recently, the detection of autoantibodies such as RF and anti-CCP Ab has provided an important basis for early diagnosis and assessment of disease activity [46,47]. In this study, the signi cant predictors of RA compared to OA were xerostomia (AUC = 0.900), anti-CCP Ab (AUC = 0.808), and RF (AUC = 0.746).…”

Hematolojik Malignitesi Ve Solid Organ Tümörü Olan Hastalarda RF VE ANTİ-CCP Pozitiflik Oranlarının Saptanması

“…Siklik peptid içeren sitrulin antikorları anti-cyclic citrullinated peptide (Anti-CCP) RA için yeni ve RF'den çok daha özgül bir parametre olarak bildirilmektedir. CCP'ye karşı oluşan antikorlar, çoğunlukla IgG sınıfındadır ve RA için %96,6 oranında özgüldür [8]. Hastalarda hastalığın erken aşamasında da tespit edilebilmektedir [9].…”