Diagnostic value of blood parameters for community-acquired pneumonia

Huang, Yung-Cheng; Liu, Aihua; Liang, Ling; Jiang, Jian; Luo, Haihua; Deng, Weiming; Lin, Guohui; Wu, Maosheng; Li, Tianwang; Jiang, Yong

doi:10.1016/j.intimp.2018.08.022

Cited by 96 publications

(98 citation statements)

References 23 publications

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“…Recently combinations of some laboratory tests have been used in some settings to show the hyperinflammation state and prognosis. These combinations include neutrophil to lymphocyte ratio (NLR), lymphocyte to C-reactive protein ratio (LCR ( (8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Laboratory features in severe vs. non-severe COVID-19 patients, a systematic review and meta-analysis

Ghahramani

Tabrizi

Lankarani

et al. 2020

Preprint

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OBJECTIVE: Understanding the common laboratory features of COVID-19 in severe cases versus non-severe patients could be quite useful for clinicians and might help to predict the model of disease progression. MATERIALS AND METHODS: Electronic databases were systematically searched in PubMed, EMBASE, Scopus, Web of ‎Science, and Google Scholar from inception to 3rd of March 2020. Heterogeneity across included ‎studies was determined using Cochrane’s Q test and the I2 statistic. We used the fixed or random-effect models to pool ‎the weighted mean differences (WMDs) or standardized mean differences and 95% confidence ‎intervals (CIs).‎RESULTS:‎ Out of a total of 3009 citations, 17 articles (22 studies, 21 from China and one study from Singapour) with 3396 ranging from 12-1099 patients, ‎were included. Our meta-analyses showed a significant decrease in ‎lymphocyte, monocyte, and eosinophil, hemoglobin, platelet, albumin, serum sodium, lymphocyte to C-reactive protein ratio (LCR), leukocyte to C-reactive protein ratio (LeCR), leukocyte to IL-6 ratio (LeIR), and an increase in the ‎neutrophil, alanine ‎aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, blood urea nitrogen (BUN), creatinine (Cr), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), fibrinogen, prothrombin time (PT), D-dimer, glucose ‎level, and neutrophil to lymphocyte ratio (NLR) in the severe group compared with the non-severe group. However, no significant changes were observed in white blood cells (WBC), ‎ creatine kinase (CK), troponin I, myoglobin, interleukin-6 (IL-6), and potassium (K) between the two groups.‎CONCLUSIONS: This meta-analysis provides evidence for the differentiation of severe cases of COVID-19 based on laboratory test results at the time of hospital admission. Future well-methodologically designed studies from other populations are strongly recommended.

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Section: Introductionmentioning

confidence: 99%

Laboratory features in severe vs. non-severe COVID-19 patients, a systematic review and meta-analysis

Ghahramani

Tabrizi

Lankarani

et al. 2020

Preprint

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“…The results of clinical chemistry and pathology show that the infection has serious damage (cell necrosis) to the liver. The change of liver function is also an important diagnostic index after pneumonia infection (Huang et al, ). Liver function has returned to normal after treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Clinicopathological results showed that App infection can cause severe inflammatory reaction (Bossé et al, 2002 (Huang et al, 2018). Liver function has returned to normal after treatment.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of enteric‐coated tilmicosin granules in pigs artificially infected with Actinobacillus pleuropneumoniae serotype 2

Dong

Zhou

Sun

et al. 2019

Veterinary Medicine & Sci

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Background Porcine infectious pleuropneumonia caused by Actinobacillus pleuropneumoniae (App) is one of the most serious infectious diseases in pigs and has brought huge economic losses to the world pig industry. The aim of this trial was to evaluate the effect of enteric‐coated tilmicosin granule in the treatment and control of artificial infection of App. Methods Sixty Duroc and Yorkshire crossbred pigs (50 of which were artificially infected) were divided into six groups: BCG (Blank control group), ICG (Infection‐only control group), HDG (High‐dose enteric‐coated tilmicosin granules), MDG (Medium‐dose enteric‐coated tilmicosin granules), LDG (Low‐dose enteric‐coated tilmicosin granules) and TPG (Tilmicosin premix drug control group). The cure rate, mortality, clinical respiratory score, body temperature score, weight gain, lung score and so on were recorded. Results The cure rate of HDG and MDG was as high as 90%, the mortality was 10%, and the clinical signs recovered quickly. Conclusion The results showed that enteric‐coated tilmicosin granules had obvious therapeutic effect on artificial infection, which could reduce the damage caused by the disease and reduce the mortality.

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“…Additionally, NLR is used as a predictor of community acquired pneumonia (CAP), specifically in elderly patients. [17][18][19] CRP is a common indicator of the inflammatory response. Its prediction value of disease progression has been reported in MERS, influenza-infected and CAP patients.…”

Section: Age Has Been Reported As An Important Independent Predictor mentioning

confidence: 99%

Development and validation of an early warning score (EWAS) for predicting clinical deterioration in patients with coronavirus disease 2019

Guo

Liu

et al. 2020

Preprint

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Diagnostic value of blood parameters for community-acquired pneumonia

Cited by 96 publications

References 23 publications

Laboratory features in severe vs. non-severe COVID-19 patients, a systematic review and meta-analysis

Laboratory features in severe vs. non-severe COVID-19 patients, a systematic review and meta-analysis

Efficacy of enteric‐coated tilmicosin granules in pigs artificially infected with Actinobacillus pleuropneumoniae serotype 2

Development and validation of an early warning score (EWAS) for predicting clinical deterioration in patients with coronavirus disease 2019

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