Diagnostic value of bronchoscopy, CT and transbronchial biopsies in diffuse pulmonary lymphangiomatosis: case report and review of the literature

Hajj, L. El; Mazières, Julien; Rouquette, Isabelle; Mittaine, M.; Bolduc, J.P.; Didier, A.; Dahan, Marcel; Joffre, F; Chabbert, V.

doi:10.1016/j.crad.2005.03.006

Cited by 23 publications

(18 citation statements)

References 14 publications

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“…However, if the lesions do not present with a distinct mass as our case demonstrated, the diagnoses and proper treatments can be delayed. Nonspecific CT findings such as interlobular, septal thickening and peribronchovascular cuffing could be suggestive of disseminated pulmonary lymphangiomatosis 5 . Especially, lytic bone lesions, as in our case, which can be a manifestation of bony involvement of lymphangiomatosis, could suggest the thoracic lymphangiomatosis 6 …”

mentioning

confidence: 61%

Cutaneous lymphangioma as a diagnostic clue for thoracic lymphangiomatosis

Bae¹,

Do²,

Kim

et al. 2010

British Journal of Dermatology

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mentioning

confidence: 61%

Cutaneous lymphangioma as a diagnostic clue for thoracic lymphangiomatosis

Bae¹,

Do²,

Kim

et al. 2010

British Journal of Dermatology

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“…It manifests equally in both sexes, mostly in children and young adults (3). Symptoms include dyspnea, nonproductive cough, bronchial casts, milky sputum, fever, and recurrent pneumonia.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Diffuse Pulmonary Lymphangiomatosis in a Middle-Aged Woman

et al. 2014

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Diffuse pulmonary lymphangiomatosis (DPL) is a rare lymphatic disorder characterized by lymphatic channel proliferation. It is mostly reported in children and young adults. Here, we report a case involving a 52-year-old asymptomatic woman who presented with increased interstitial markings, as seen on a chest radiograph. Diffuse interstitial septal thickening was found on a serial follow-up chest computed tomography scan, and lymphangitic metastasis was the primary radiologic differential diagnosis. However, histologic sections of wedge resected lung revealed diffuse pleural and interlobular septal lymphatic proliferation characteristic of DPL.

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“…Although spindle cells in kaposiform hemangioendothelioma are morphologically similar to small plaque-like proliferation of smooth muscle cells seen in lymphangiomatosis, kaposiform hemangioendothelioma has a vascular rather than a smooth muscle character and shows a solid growth pattern; furthermore, it is characterized by actin-negative, CD34positive cells with electron microscopic features of vascular cells. 3 In our review of the English literature (Table 1), [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] 36 patients who had diffuse pulmonary involvement included 23 male and 13 female patients, aged between 1 month and 53 years. The CT findings in all cases were characterized by smooth thickening of the interlobular septa and bronchovascular bundles.…”

Section: Discussionmentioning

confidence: 99%

Diffuse pulmonary lymphangiomatosis: Pulmonary lymphatic disorder in an adult

Yoo

Song

Lee

et al. 2012

Basic and Applied Pathology

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Diffuse pulmonary lymphangiomatosis (DPL) is a rare disorder involving the intrathoracic lymphatic system from the mediastinum to the pleura. Although DPL is a lymphatic developmental abnormality and is pathologically benign, it has various clinical presentations and a progressive course. We recently studied a case of DPL in a 35‐year‐old man presenting with cough and hemoptysis with unilateral chylothorax. A chest computed tomography scan showed diffuse interstitial thickening along the peribronchovascular bundles and intralobular septae with pleural and pericardial effusion. Wedge resection of the left lower lung was performed to make a diagnosis. Microscopically, the lesion was characterized by variably sized and increased lymphatic channels of the interlobular septa and subpleural area. The cells lining the lymphatics were immunohistochemically positive for D2–40 and CD34. This patient is still alive without recurrent symptoms 13 months after beginning a low‐fat medium‐chain triglyceride diet and chemical pleurodesis.

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Diagnostic value of bronchoscopy, CT and transbronchial biopsies in diffuse pulmonary lymphangiomatosis: case report and review of the literature

Cited by 23 publications

References 14 publications

Cutaneous lymphangioma as a diagnostic clue for thoracic lymphangiomatosis

Cutaneous lymphangioma as a diagnostic clue for thoracic lymphangiomatosis

A Rare Case of Diffuse Pulmonary Lymphangiomatosis in a Middle-Aged Woman

Diffuse pulmonary lymphangiomatosis: Pulmonary lymphatic disorder in an adult

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