Diagnostic Value of C-Reactive Protein for Predicting Activity Level of Crohn’s Disease

Chamouard, P.; Richert, Z.; Meyer, Nicolás; Rahmi, Gabriel; Baumann, René

doi:10.1016/j.cgh.2006.02.003

Cited by 51 publications

(33 citation statements)

References 23 publications

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“…Furthermore, we found that CD patients younger than 10 years had lower PCDAI. As in adult studies, Crohn colitis was associated with lower disease activity and with less frequently elevated CRP (14). Complicated disease behaviour was also related to abnormal laboratory results (CRP, iron levels).…”

Section: Discussionmentioning

confidence: 67%

Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease

Müller

Lakatos

Kovács

et al. 2016

J. pediatr. gastroenterol. nutr.

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Section: Discussionmentioning

confidence: 67%

Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease

Müller

Lakatos

Kovács

et al. 2016

J. pediatr. gastroenterol. nutr.

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“…CRP levels are found to be weakly associated with clinical activity indices by several authors [14,[19][20][21] , although this has not been reported consistently [22] . Colombel et al reported a striking correlation of CRP levels with radiologic fi ndings of perienteric inflammation [12] .…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein levels during a relapse of Crohn’s disease are associated with the clinical course of the disease

Koelewijn¹,

Schwartz²,

Samsom³

et al. 2008

WJG

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AIM:To explore if C-reactive protein (CRP) levels might serve as a prognostic factor with respect to the clinical course of Crohn's disease and might be useful for classifi cation. METHODS:In this retrospective cohort study we enrolled 94 patients from the inflammatory bowel disease (IBD) database of the University Medical Centre Utrecht. CRP levels during relapse were correlated with the number of relapses per year. Severity of relapses was based on endoscopic reports and prednisone use. Furthermore, patients were categorized in a low or high CRP group based on their CRP response during relapse and demographic and clinical features were compared. RESULTS:Overall, a positive correlation between CRP levels, number of relapses, and severity of relapse was found (respectively r s = 0.31, P < 0.01 and r s = 0.50, P < 0.001). Employing a cut-off level of 15 mg/L, the index CRP level was found to discriminate patients with respect to the number of relapses per year, as well as for severity of relapses (respectively 0.25 ± 0.16 vs 0.36 ± 0.24, P < 0.05 and 4.4 ± 1.2 vs 3.2 ± 1.1 on a 10-point visual analogue scale, P < 0.001 for the high CRP and low CRP groups respectively). In addition, the high CRP group showed more cumulative days of prednisone use per year (107 ± 95 vs 58 ± 48, P < 0.05), as well as a better response to infl iximab (93 % vs 33 %, P = 0.06). CONCLUSION:A higher CRP level during relapse seems to be associated with a more severe clinical course of disease.

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“…The measurement of inflammatory activity in CD is important not only in clinical trials but also in the setting of everyday practice to predict the course of the disease and to monitor effects of treatment [10,18,19]. An ideal biomarker should be disease specific, easy to perform, non-or minimally invasive, and providing rapid and reproducible results.…”

Section: Discussionmentioning

confidence: 99%

Serum C-reactive protein level does not correlate with Crohn’s Disease Activity Index

Kohut¹,

Kozioł²,

Olek³

et al. 2010

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Introduction: Crohn's Disease Activity Index (CDAI) is a conventional, but poorly validated estimate of severity of Crohn's disease (CD). Similarly, the clinical significance of elevated levels of C-reactive protein (CRP) in CD patients is not well recognized. It is also unknown whether these two indices have similar informative value. Aim: To investigate the correlation between serum CRP level and CDAI. Material and methods: One hundred and forty-six patients (66 men and 80 women, mean age 37 ±12 years) with well established diagnosis of CD were included in the study. According to the admittance protocol in all patients the serum CRP was measured and all data necessary to calculate CDAI were collected. Results: There was no significant correlation between CRP and CDAI either in the entire population or in subgroups selected on the basis of CD severity, site of bowel involvement, kind of ongoing pharmacological therapy, past surgery or body mass. Conclusions: There is no correlation between serum CRP level and CDAI. These two indices reflect different aspects of CD severity.

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Diagnostic Value of C-Reactive Protein for Predicting Activity Level of Crohn’s Disease

Cited by 51 publications

References 23 publications

Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease

Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease

C-reactive protein levels during a relapse of Crohn’s disease are associated with the clinical course of the disease

Serum C-reactive protein level does not correlate with Crohn’s Disease Activity Index

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