Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer

Okamura, Kyoko; Takayama, K.; Izumi, Miiru; Harada, Taishi; Furuyama, Kazuto; Nakanishi, Yoichi

doi:10.1016/j.lungcan.2013.01.002

Cited by 181 publications

(146 citation statements)

References 20 publications

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“…al., (7.9 ± 34.6 ng/ml) who earlier demonstrated that the mean CYFRA21-1 levels in patients with NSCLC were higher compare to the control groups. Moreover, this study showed results in vicinity to these earlier reports [22,23] Sugama et al [24] reported earlier that increased serum levels of CYFRA 21-1 in NSCLC patients were not only due to cytokeratin release as a result of cell lysis or necrosis, but also due to the degradation of cytokeratin filaments by activated protease (caspase 3) in tumor cells.…”

Section: Discussionsupporting

confidence: 84%

Prognostic Value of CYFRA 21-1 and Carcinoembryonic Antigen in Non-Small Cell Lung Cancer

Said¹,

Abd-Elnaeem²,

Mohamed³

et al. 2015

J Clin Cell Immunol

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Section: Discussionsupporting

confidence: 84%

Prognostic Value of CYFRA 21-1 and Carcinoembryonic Antigen in Non-Small Cell Lung Cancer

Said¹,

Abd-Elnaeem²,

Mohamed³

et al. 2015

J Clin Cell Immunol

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“…Up to now, a series of biomarkers for discerning lung cancer and monitoring progress have been detected in serum, such as CEA, CYFRA21-1, NSE, and so on (19,20). Serum biomarkers predicting patient prognosis or response to therapy may make progress in the potential of personalized medicine in cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

Increased stathmin in serum as a potential tumor marker for lung adenocarcinoma

Biaoxue

Liu

Tian

et al. 2017

Japanese Journal of Clinical Oncology

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Background: Stathmin has been found to be involved in malignant tumors; the aim of this study was to investigate the relationship between serum stathmin and clinico-pathological features of lung cancer. Methods: In three lung cancer cell lines, stathmin expression and its secretion level in the supernatant were examined by Western blot and enzyme-linked immunosorbent assay (ELISA). Expression of stathmin was examined by immunohistochemistry in 48 lung cancer tissues, and serum stathmin expression level was examined by ELISA in 96 patients with lung cancer and 82 normal individuals. Sensitivity and specificity of serum stathmin were determined by receiver operator characteristic curve (ROC). Results: In the three cell lines and their supernatant, stathmin levels were higher than those in 16 HBE cell line. Lung cancer tissues expressed higher level stathmin more frequently than normal lung tissue (P < 0.05). Serum stathmin level was significantly higher in the patients with lung cancer than in normal individuals (P < 0.001). Increased stathmin level in cancer tissue and serum were significantly associated with adenocarcinoma histology, lymph node metastasis and advanced stage. The threshold level of serum stathmin for distinguishing lung cancer from normal individuals was 1.86 ng/ml. The sensitivity and specificity were 93.7% and 91.5%, respectively. Conclusions: Measurement of serum stathmin level could be a potential biomarker for lung cancer, especically those of adenocarcinoma, with lymph node metastasis and at advanced clinical stages.

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“…CEA is considered to be the preferred indicator of lung adenocarcinoma (20). Table II shows that the positive expression rates of CEA in squamous cell carcinoma and adenocarcinoma were 42.9 and 73.3%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Detection of cancer embryo antigen and endothelin-1 in exhaled breath condensate: A novel approach to investigate non-small cell lung cancer

Chen

et al. 2016

Molecular and Clinical Oncology

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Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer

Cited by 181 publications

References 20 publications

Prognostic Value of CYFRA 21-1 and Carcinoembryonic Antigen in Non-Small Cell Lung Cancer

Prognostic Value of CYFRA 21-1 and Carcinoembryonic Antigen in Non-Small Cell Lung Cancer

Increased stathmin in serum as a potential tumor marker for lung adenocarcinoma

Detection of cancer embryo antigen and endothelin-1 in exhaled breath condensate: A novel approach to investigate non-small cell lung cancer

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