Diagnostic value of Chest CT and Initial Real-Time RT-PCR in COVID-19 Infection

Kostakoğlu, Uğur; Kant, Aydın; Atalar, Serhat; Ertunç, Barış; Erensoy, Şükrü; Dalmanoğlu, Enes; Yılmaz, İsmail; Sevimli, Belgin Kilic; Ertürk, Ayşe; Yılmaz, Gürdal

doi:10.12669/pjms.37.1.2956

Cited by 3 publications

(7 citation statements)

References 17 publications

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“…It has been reported that the missed diagnosis of COVID-19 by CT is low (3.9%) (13). CT positivity was reported as 64% in the study of Kostaoğlu et al (12). In our study, on thoracic CT, typical appearance compatible with COVID-19 was present in 189 (11.9%) cases.…”

Section: Betweensupporting

confidence: 53%

“…In the study of Jin et al, 37% were reported to have at least one comorbidity (18). In the study of Kostaoğlu colleagues, the most common comorbidity was hypertension (12). In a study conducted in Iran, diabetes, chronic respiratory disease, and hypertension were the most common comorbidities (20).…”

Section: Betweenmentioning

confidence: 97%

“…Typical CT findings are diagnostic in patients until RT-PCR results are available (12). RT-PCR should be repeated to avoid the isolation and misdiagnosis of patients with typical CT findings and negative RT-PCR results.…”

Section: Betweenmentioning

confidence: 99%

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Evaluation of Covid-19 cases that applied to the hospital at the first peak of the pandemic

AKDOĞAN¹,

Yapar²,

ÇEBİ³

et al. 2022

JECM

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Early diagnosis in COVID-19 is essential in terms of treatment and prevention of contagiousness. In this study, we aimed to find an alternative diagnosis method by using fewer laboratory parameters in the early diagnosis of COVID-19 disease by creating a fast, easily accessible, cost-effective index and has a diagnostic accuracy rate of over 90%. All patients over the age of 18 who applied to Hitit University Erol Olçok Training and Research Hospital Emergency COVID Outpatient Clinic with a pre-diagnosis of COVID-19 between March and April 2020 were evaluated retrospectively. Patients were divided into two groups as COVID-19 positive and COVID-19 negative. It was aimed to create a HITIT-19 index by evaluating the cases according to the clinical and laboratory results. Between March and April 2020 (in the first peak of the pandemic), 1586 patients were applied to the Emergency COVID-19 outpatient clinic with a pre-diagnosis of COVID-19. According to COVID-19 RT-PCR, card test, and CT involvement, 285 (13%) patients were diagnosed with COVID-19. PCR was positive in 285 (18%) of 1586 patients, and PCR was negative in 1301 (82%). While 153 (53.7%) of the patients diagnosed with COVID-19 were male and the median age was 45 (28-62.75), 883 (55.7%) of the patients not diagnosed with COVID-19 were male, and the median age was 43 (31-65). Hypertension (HT) was the most common underlying disease in 10.5% of patients applied to the emergency room with a diagnosis of COVID-19, while 38.9% dyspnea and 35.1% fever were the most common symptoms. While 76% of Plaquenil and 58% azithromycin were the most frequently started treatments, 31.4% (28.4% of them were hospitalized in the service, 3% in the intensive care unit) of them hospitalized. It was to create a HITIT-19 index that is fast, easily accessible, cost-effective, and has a diagnostic accuracy rate of over 90% by using laboratory tests. However, we could not achieve this goal due to the low accuracy of the diagnostic tests and the lack of significant change in the laboratory levels of the patients at admission. Considering that the pandemic is continuing rapidly, there is still a need to develop practical diagnostic methods that are easier and cheaper in diagnosis. In this sense, we believe that our study will be a guiding study for other studies that will be designed for diagnostic index studies.

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Section: Betweensupporting

confidence: 53%

Section: Betweenmentioning

confidence: 97%

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Evaluation of Covid-19 cases that applied to the hospital at the first peak of the pandemic

AKDOĞAN¹,

Yapar²,

ÇEBİ³

et al. 2022

JECM

View full text Add to dashboard Cite

show abstract

“…On the other hand, a retrospective cohort analysis in New York by Zacharioudakis et al (n = 42) showed that a three-fold increase in Ct value denoted a correlation with a 0.15 improvement in terms of genomic load on Sequential Organ Failure Assessment (SOFA) score [100][101][102][103][104][105][106]. Another larger study with 192 patients revealed that patients who died in hospital had significantly lower Ct values than those who were discharged alive [100].…”

Section: Disease Severitymentioning

confidence: 99%

“…Poor prognosis of COVID-19 case management is reported due to various co-morbidities. Prolonged viral shedding is seen in mild COVID-19 patients with older age, hypertension, and diabetes mellitus [13,101].…”

Section: Co-morbiditiesmentioning

confidence: 99%

Viral Dynamics and Real-Time RT-PCR Ct Values Correlation with Disease Severity in COVID-19

et al. 2021

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Real-time RT-PCR is considered the gold standard confirmatory test for coronavirus disease 2019 (COVID-19). However, many scientists disagree, and it is essential to understand that several factors and variables can cause a false-negative test. In this context, cycle threshold (Ct) values are being utilized to diagnose or predict SARS-CoV-2 infection. This practice has a significant clinical utility as Ct values can be correlated with the viral load. In addition, Ct values have a strong correlation with multiple haematological and biochemical markers. However, it is essential to consider that Ct values might be affected by pre-analytic, analytic, and post-analytical variables such as collection technique, specimen type, sampling time, viral kinetics, transport and storage conditions, nucleic acid extraction, viral RNA load, primer designing, real-time PCR efficiency, and Ct value determination method. Therefore, understanding the interpretation of Ct values and other influential factors could play a crucial role in interpreting viral load and disease severity. In several clinical studies consisting of small or large sample sizes, several discrepancies exist regarding a significant positive correlation between the Ct value and disease severity in COVID-19. In this context, a revised review of the literature has been conducted to fill the knowledge gaps regarding the correlations between Ct values and severity/fatality rates of patients with COVID-19. Various databases such as PubMed, Science Direct, Medline, Scopus, and Google Scholar were searched up to April 2021 by using keywords including “RT-PCR or viral load”, “SARS-CoV-2 and RT-PCR”, “Ct value and viral load”, “Ct value or COVID-19”. Research articles were extracted and selected independently by the authors and included in the present review based on their relevance to the study. The current narrative review explores the correlation of Ct values with mortality, disease progression, severity, and infectivity. We also discuss the factors that can affect these values, such as collection technique, type of swab, sampling method, etc.

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Ground Glass Opacities in Lung Cancer Patients Positive for Covid-19

TARIQ

IRFAN²,

Sattar

et al. 2023

Biol Clin Sci Res J

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This study was designed to evaluate radiological features of COVID-19 and early lung cancer through High-resolution computed tomography (HRCT) and demonstrated the disparity between them. A retrospective was conducted in the COVID-19 ward, Oncology & Radiology ward of CH& UCHS Lahore & Shifa International Hospital Islamabad & NMU & H Multan from October 14, 2019, to October 14, 2020. A total of 100 COVID-19 patients and 300 patients with pulmonary ground-glass opacities undergoing lung surgery (control group) were included in the study. After propensity score-matched analysis, patients were divided into two groups with 80 matched pairs each. Both groups' clinical, pathological, epidemiological, and radiological characteristics (evaluated through HRCT) were compared. It was observed that COVID-19 patients presented more definite symptoms, were mostly younger men, and had higher BMI (body-mass index). After the radiological analysis of the matched patients, it was revealed that single-lesion patients constituted 17% of COVID-19 cases and 89% of lung cancer cases. Patients in both groups mainly presented peripheral lesions. COVID-19 lesions had more lobes and segments and had various types with patchy forms. On the other hand, lung cancer tended to have only one type and had an oval form. Both COVID-19 and lung cancer showed ground-glass opacities with similar but independent characteristics. These characteristics, combined with pathogen detection, short-term CT examination, and laboratory tests, will aid in improved diagnosis.

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Diagnostic value of Chest CT and Initial Real-Time RT-PCR in COVID-19 Infection

Cited by 3 publications

References 17 publications

Evaluation of Covid-19 cases that applied to the hospital at the first peak of the pandemic

Evaluation of Covid-19 cases that applied to the hospital at the first peak of the pandemic

Viral Dynamics and Real-Time RT-PCR Ct Values Correlation with Disease Severity in COVID-19

Ground Glass Opacities in Lung Cancer Patients Positive for Covid-19

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