Objective: To evaluate the usefulness of low-dose CT (LDCT) for the diagnosis of acute lower respiratory infection (ALRI) in elderly patients in the emergency room (ER). Methods: A total of 160 consecutive patients (mean age: 75.9 6 9.2 years; range: 60-97 years), who were diagnosed to have ALRI by LDCT in the ER, were enrolled in this study. Initial chest radiograph (CR) and CT patterns of ALRI were analysed, and clinical courses of patients were assessed. Results: 49 patients showed negative CR, in whom the main CT patterns were diffuse bronchial wall thickening (n 5 23), ground-glass opacity (n 5 6), mixed centrilobular nodules and ground-glass opacity (n 5 3), small consolidation (n 5 8) or consolidation in the dependent lung (n 5 9), while the other 111 patients with the main CT pattern of consolidation demonstrated pulmonary abnormality on CR. Pulmonary oedema (12.5%) and pleural effusion (23.1%) were associated. The rate of hospitalization, care in the intensive care unit, mortality and comorbidity were significantly higher in the CR(1)LDCT(1) group (88.3%, 36.1%, 18.2% and 59.5%) than in the CR(2)LDCT (1) group (55.1%, 8.2%, 2.0% and 38.8%; p # 0.05). Conclusion: LDCT was useful for the early diagnosis of ALRI in elderly patients who showed negative initial CR. The patients with negative initial CR had main CT patterns of diffuse bronchial wall thickening, ground-glass opacity, centrilobular nodules, small consolidation or consolidation in the dependent lung on LDCT. Advances in knowledge: The use of LDCT may be considered for the early diagnosis of ALRI in elderly patients who have high comorbidity.
INTRODUCTIONWith increasing global life expectancy and the number of persons aged 65 years and older in the general population, the population of the elderly suffering from acute lower respiratory infection (ALRI) is increasing. Elderly people are more susceptible to pulmonary infection, owing to their decreased immunity and chronic comorbid illness. Complications, including septic shock or acute respiratory distress syndrome, can be life threatening. However, the diagnosis of ALRI in the elderly is often difficult owing to its non-specific manifestations, 1 because the symptoms and signs in elderly patients can differ from the general population and are sometimes not specific.