Diagnostic value of combined 18F-FDG PET/MRI for staging and restaging in paediatric oncology

Pfluger, Thomas; Melzer, Henriette Ingrid; Mueller, Wolfgang P.; Coppenrath, Eva; Bartenstein, Peter; Albert, Michael H.; Schmid, Irene

doi:10.1007/s00259-012-2228-3

Cited by 44 publications

(16 citation statements)

References 35 publications

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“…A meta-analysis by Wu et al (25) demonstrated almost equal sensitivities (;90%) of 18 F-FDG PET/CT and MR for diagnosing lymphoma with bone marrow involvement. The specificity of MR has been reported to be lower than that of 18 F-FDG PET because posttherapeutic changes, such as bone marrow edema, necrotic tissue, or age-dependent changes in the appearance of bone marrow in children, may lead to misinterpretation (25,26). A retrospective analysis of the diagnostic value of combined and coregistered 18 F-FDG PET/MR in pediatric oncology (mainly lymphoma) did not miss any bone or bone marrow lesions relative to an analysis of each modality separately.…”

Section: Lymphomamentioning

confidence: 99%

Potential Pediatric Applications of PET/MR

et al. 2014

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Medical imaging with multimodality and whole-body technologies has continuously improved in recent years. The advent of combined modalities such as PET/CT and PET/MR offers new tools with an exact fusion of molecular imaging and high-resolution anatomic imaging. For noninvasive pediatric diagnostics, molecular imaging and whole-body MR have become important, especially in pediatric oncology. Because it has a lower radiation exposure than PET/CT, combined PET/MR is expected to be of special use in pediatric diagnostics. This review focuses on possible pediatric applications of PET/MR hybrid imaging, particularly pediatric oncology and neurology but also the diagnosis of infectious or inflammatory diseases.

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Section: Lymphomamentioning

confidence: 99%

Potential Pediatric Applications of PET/MR

et al. 2014

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“…Thus, in children, PET/MRI can add significant information to that obtained through the use of separate imaging modalities. Data on the diagnostic value of combined and registered image analysis of FDG PET and MRI for staging and re-staging in pediatric oncology have recently been published [48]. On a lesionbased analysis, PET/MRI performed significantly better than the two imaging modalities alone [48].…”

Section: Whole-body Fdg Pet/mrimentioning

confidence: 99%

Whole-body PET/MRI in oncology: current status and clinical applications

Pace

Nicolai

Aiello

et al. 2013

Clin Transl Imaging

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In oncology, diagnostic imaging plays a major role in staging, therapy assessment and in the evaluation of tumor biology. Multimodality imaging, and more specifically positron emission tomography/computed tomography (PET/CT), has matured into an important imaging tool. The recent introduction of the integrated whole-body PET/ magnetic resonance imaging (MRI) represents the addition of a promising methodology in clinical practice. Combining the metabolic data of PET with the anatomical and functional information provided by MRI and fMRI may further improve the diagnostic value of each method alone. Although the literature is still limited, data indicate a potential advantage of PET/MRI over PET/CT in all the indications where MRI is superior to CT, as well as in the evaluation of tumor biology. Integrated PET/MRI might be performed in addition to the existing imaging modality in specific regions. Moreover, integrated PET/MRI is an alternative to PET/CT when a low radiation dose is required, i.e. in children and in repeated imaging. In the rapidly evolving field of diagnostic imaging, the role of a new modality should be accurately evaluated. Further studies are needed to test the diagnostic accuracy of PET/MRI in different oncology indications. Whether PET/MRI will replace PET/CT or be a complementary methodology and whether it represents true diagnostic progress remains to be evaluated, also taking into account economic considerations.

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“…However, specificity may be limited in MRI (down to 30 %) especially in the follow-up situation (e. g., in the assessment of residual disease in Hodgkin lymphoma) [33]. In this situation, the addition of PET can significantly increase diagnostic sensitivity (up to 97 %) and specificity (up to 82 %) by combination of high anatomic resolution and high sensitivity of MRI and complementary metabolic information of PET [33]. It is thus self-evident that combined PET/MRI is indicated in patients with indications for whole-body MRI and PET.…”

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“…Whole-body MRI is the method of choice for imaging of numerous oncologic disorders in children, especially for primary diagnosis and staging [30 -32]. For this purpose, MRI provides high sensitivity for lesion detection and excellent soft-tissue contrast for local staging (up to 94 %) [16,33]. However, specificity may be limited in MRI (down to 30 %) especially in the follow-up situation (e. g., in the assessment of residual disease in Hodgkin lymphoma) [33].…”

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confidence: 99%

“…For this purpose, MRI provides high sensitivity for lesion detection and excellent soft-tissue contrast for local staging (up to 94 %) [16,33]. However, specificity may be limited in MRI (down to 30 %) especially in the follow-up situation (e. g., in the assessment of residual disease in Hodgkin lymphoma) [33]. In this situation, the addition of PET can significantly increase diagnostic sensitivity (up to 97 %) and specificity (up to 82 %) by combination of high anatomic resolution and high sensitivity of MRI and complementary metabolic information of PET [33].…”

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Pediatric Oncologic Imaging: A Key Application of Combined PET/MRI

Gatidis¹,

Fougère²,

Schaefer³

2016

Fortschr Röntgenstr

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Pediatric imaging has been identified as a key application of combined whole-body PET/MRI. First studies have revealed the clinical feasibility and possible advantages of PET/MRI over PET/CT and MRI. Besides a significant reduction in radiation exposure of about 50???75?%, combined whole-body PET/MRI offers the diagnostic advantage of the multiparametric characterization of pathophysiologic processes and helps reduce the number of necessary imaging studies. However, very few studies focusing on pediatric PET/MRI have been published to date. Additional studies are necessary in order to fully appreciate the clinical impact of this novel method. This review article shall summarize the existing literature concerning pediatric PET/MRI and give insight into the practical experience derived from over 160 pediatric PET/MRI examinations that were performed in T?bingen. Key Points: ??Combined PET/MR is a promising imaging modality in pediatric oncology. ??Using combined PET/MRI, diagnostic radiation exposure of pediatric patients and the number of necessary imaging studies can be reduced. ??Further clinical studies are necessary in order to define specific indications for combined PET/MRI in pediatric radiology. Citation Format: ??Gatidis S, la Foug?re C, Schaefer J F Pediatric Oncologic Imaging: A Key Application of Combined PET/MRI. Fortschr R?ntgenstr 2016; 188: 359???364

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Diagnostic value of combined 18F-FDG PET/MRI for staging and restaging in paediatric oncology

Cited by 44 publications

References 35 publications

Potential Pediatric Applications of PET/MR

Potential Pediatric Applications of PET/MR

Whole-body PET/MRI in oncology: current status and clinical applications

Pediatric Oncologic Imaging: A Key Application of Combined PET/MRI

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